PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33561745-0	2021	Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1alpha pathway.	rosmarinic acid	0-15	sirtuin 1	Mus musculus	127-132	
33787460-0	2021	SIRT1/NFkappaB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH).	rosmarinic acid	80-95	sirtuin 1	Mus musculus	0-5	
33787460-4	2021	The aim of this study was to explore the role of rosmarinic acid on the pathways involved by SIRT1 for amelioration of a mouse model of NASH.	rosmarinic acid	49-64	sirtuin 1	Mus musculus	93-98	
33787460-10	2021	Rosmarinic acid administration also increased SIRT1, Nrf2 and PPARalpha and decreased SREBP1c, FAS, NFkappaB and caspase3 expressions.	rosmarinic acid	0-15	sirtuin 1	Mus musculus	46-51	
33787460-12	2021	Our study demonstrated that remarkable effects of rosmarinic acid on the mice with NASH might be due to activation of SIRT1/Nrf2, SIRT1/NFkappaB and SIRT1/PPARalpha pathways, which alleviate hepatic steatosis, oxidative stress, inflammation and apoptosis.	rosmarinic acid	50-65	sirtuin 1	Mus musculus	118-123	
33787460-12	2021	Our study demonstrated that remarkable effects of rosmarinic acid on the mice with NASH might be due to activation of SIRT1/Nrf2, SIRT1/NFkappaB and SIRT1/PPARalpha pathways, which alleviate hepatic steatosis, oxidative stress, inflammation and apoptosis.	rosmarinic acid	50-65	sirtuin 1	Mus musculus	130-135	
33787460-12	2021	Our study demonstrated that remarkable effects of rosmarinic acid on the mice with NASH might be due to activation of SIRT1/Nrf2, SIRT1/NFkappaB and SIRT1/PPARalpha pathways, which alleviate hepatic steatosis, oxidative stress, inflammation and apoptosis.	rosmarinic acid	50-65	sirtuin 1	Mus musculus	130-135	
33561745-8	2021	Further mechanistic studies in H9c2 cardiomyocytes revealed that suppression of SIRT1 by Sh-SIRT1 counteracted the effects of RA on high glucose-induced abnormal metabolism of glucose and lipids, oxidative stress and apoptosis (P < 0.05).	rosmarinic acid	126-128	sirtuin 1	Mus musculus	92-97	
33561745-9	2021	Taken together, these data indicate that RA prevented mitochondrial injury and cardiac dysfunction in DCM mice, and the SIRT1/PGC-1alpha pathway mediated the protective effects of RA.	rosmarinic acid	180-182	sirtuin 1	Mus musculus	120-125	
33561745-7	2021	Moreover, RA upregulated the expression of SIRT1 and PGC-1alpha in DCM mice and high glucose-treated H9c2 cardiomyocytes (P < 0.05).	rosmarinic acid	10-12	sirtuin 1	Mus musculus	43-48	
33561745-8	2021	Further mechanistic studies in H9c2 cardiomyocytes revealed that suppression of SIRT1 by Sh-SIRT1 counteracted the effects of RA on high glucose-induced abnormal metabolism of glucose and lipids, oxidative stress and apoptosis (P < 0.05).	rosmarinic acid	126-128	sirtuin 1	Mus musculus	80-85