PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27923634-0	2017	Rosmarinic acid protects rat hippocampal neurons from cerebral ischemia/reperfusion injury via the Akt/JNK3/caspase-3 signaling pathway.	rosmarinic acid	0-15	caspase 3	Rattus norvegicus	108-117	
29376419-2	2018	Pretreatment with RA significantly suppressed the generation of ROS, protected the morphological changes of cells, decrease the ratio of cell apoptosis, down-regulated the level of caspase-3, caspase-9, Bax/Bcl-2, and up-regulated the level of p-PI3K.	rosmarinic acid	18-20	caspase 3	Rattus norvegicus	181-190	
27923634-11	2017	Furthermore, RA increased the phosphorylation of Akt1, downregulated the phosphorylation of JNK3 and reduced the expression of cleaved caspase-3.	rosmarinic acid	13-15	caspase 3	Rattus norvegicus	135-144	
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	rosmarinic acid	75-77	caspase 3	Rattus norvegicus	187-196	
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	rosmarinic acid	95-97	caspase 3	Rattus norvegicus	187-196	
27402269-5	2016	Moreover, the effect of RA on apoptosis was related with improved mitochondrial function, which was demonstrated by that RA attenuated high glucose-induced ROS generation, inhibited mitochondrial permeability transition pore (MPTP) activation, suppressed cytochrome c release and caspase-3 activation.	rosmarinic acid	24-26	caspase 3	Rattus norvegicus	280-289	
27402269-5	2016	Moreover, the effect of RA on apoptosis was related with improved mitochondrial function, which was demonstrated by that RA attenuated high glucose-induced ROS generation, inhibited mitochondrial permeability transition pore (MPTP) activation, suppressed cytochrome c release and caspase-3 activation.	rosmarinic acid	121-123	caspase 3	Rattus norvegicus	280-289	
24085626-4	2014	Additionally, pretreatment with RA potentiated the decrease of Bcl-2 expression and attenuated the increase of Caspase-3 expression by CoCl2.	rosmarinic acid	32-34	caspase 3	Rattus norvegicus	111-120	
24085626-6	2014	CoCl2-induced increase of Bax/Bcl-2 ratio and Caspase-3 expression was attenuated by RA, NAC and SB203580 (p38MAPK inhibitor).	rosmarinic acid	85-87	caspase 3	Rattus norvegicus	46-55