PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23116643-9	2013	The hepatoprotective activity of RA coincided with enhanced NF-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression.	rosmarinic acid	33-35	heme oxygenase 1	Mus musculus	94-110	
33530569-7	2021	Furthermore, nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) protein expression increased after the RA-loaded nanovesicles treatment However, these mechanistic changes were not detected with the RA-free treatment.	rosmarinic acid	131-133	heme oxygenase 1	Mus musculus	68-84	
33530569-7	2021	Furthermore, nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) protein expression increased after the RA-loaded nanovesicles treatment However, these mechanistic changes were not detected with the RA-free treatment.	rosmarinic acid	131-133	heme oxygenase 1	Mus musculus	86-90	
30597292-0	2019	Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-kappaB and activating Nrf2/HO-1 signaling pathways.	rosmarinic acid	0-15	heme oxygenase 1	Mus musculus	147-151	
30597292-5	2019	Furthermore, RA promoted that nuclear factor erythroid-2-related factor 2 (Nrf2) transported into nucleus, and then up-regulated heme oxygenase 1 (HO-1), glutamate-cysteine ligase catalytic (GCLC), glutamate cysteine ligase modifier (GCLM) and quinone oxidoreductase (NQO1).	rosmarinic acid	13-15	heme oxygenase 1	Mus musculus	129-145	
30597292-5	2019	Furthermore, RA promoted that nuclear factor erythroid-2-related factor 2 (Nrf2) transported into nucleus, and then up-regulated heme oxygenase 1 (HO-1), glutamate-cysteine ligase catalytic (GCLC), glutamate cysteine ligase modifier (GCLM) and quinone oxidoreductase (NQO1).	rosmarinic acid	13-15	heme oxygenase 1	Mus musculus	147-151	
30323140-0	2018	Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling.	rosmarinic acid	0-15	heme oxygenase 1	Mus musculus	72-88	
30323140-8	2018	RA (20 and 40 mg/kg) greatly improved neurological function, reduced infarct volume, decreased cell apoptosis, upregulated Bcl-2 protein and mRNA expression, downregulated Bax protein and mRNA expression, increased HO-1 and Nrf2 protein and mRNA expression, increased superoxide dismutase activity, and decreased malondialdehyde levels in ischemic brain tissue of model mice.	rosmarinic acid	0-2	heme oxygenase 1	Mus musculus	215-219	
30323140-9	2018	However, intraperitoneal injection of a HO-1 inhibitor (10 mg/kg zinc protoporphyrin IX) reversed the neuroprotective effects of RA on HO-1 enzyme activity and Bcl-2 and Bax protein expression.	rosmarinic acid	129-131	heme oxygenase 1	Mus musculus	40-44	
30323140-9	2018	However, intraperitoneal injection of a HO-1 inhibitor (10 mg/kg zinc protoporphyrin IX) reversed the neuroprotective effects of RA on HO-1 enzyme activity and Bcl-2 and Bax protein expression.	rosmarinic acid	129-131	heme oxygenase 1	Mus musculus	135-139	
30323140-11	2018	Our findings suggest that RA has anti-oxidative and anti-apoptotic properties that protect against ischemic stroke by a mechanism involving upregulation of Nrf2 and HO-1 expression via the PI3K/Akt signaling pathway.	rosmarinic acid	26-28	heme oxygenase 1	Mus musculus	165-169