PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26981780-4	2016	The combination of [ruxolitinib + MMF] inactivated ERK1/2, AKT, STAT3 and STAT5; reduced expression of MCL-1, BCL-XL, SOD2 and TRX; increased BIM expression; decreased BAD S112 S136 phosphorylation; and enhanced pro-caspase 3 cleavage.	ruxolitinib	20-31	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	103-108	
33747209-0	2021	Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2-STAT1-Mcl-1 axis.	ruxolitinib	0-11	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	98-103	
33747209-7	2021	Then, ruxolitinib downregulated myeloid cell leukemia-1 (Mcl-1) mRNA level and decreased its protein level, which enabled Bak to trigger CRC apoptosis.	ruxolitinib	6-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	32-55	
33747209-7	2021	Then, ruxolitinib downregulated myeloid cell leukemia-1 (Mcl-1) mRNA level and decreased its protein level, which enabled Bak to trigger CRC apoptosis.	ruxolitinib	6-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	57-62	
33747209-10	2021	Taken together, the results showed that ruxolitinib decreased JAK1/2-STAT1-Mcl-1 protein level and effectively suppressed CRC cell proliferation in vitro and in vivo.	ruxolitinib	40-51	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	75-80	
29928488-3	2018	We have found that ruxolitinib downregulated the mTORC1/S6K/4EBP1 pathway at least partly through inhibition of the STAT5/Pim-2 pathway with concomitant downregulation of c-Myc, MCL-1, and BCL-xL as well as induction of autophagy in these cells.	ruxolitinib	19-30	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	178-183	
26811457-8	2016	The use of the two-agent combination of either ruxolitinib or Navitoclax with BV or the three-agent combination strongly activated Bax and increased activities of cytochrome c and caspase-9 and -3 that, in turn, led to cleavage of poly(ADP ribose) polymerase and Mcl-1.	ruxolitinib	47-58	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	263-268