PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26055227-0 2016 Paliperidone Protects SH-SY5Y Cells Against MK-801-Induced Neuronal Damage Through Inhibition of Ca(2+) Influx and Regulation of SIRT1/miR-134 Signal Pathway. Paliperidone Palmitate 0-12 sirtuin 1 Homo sapiens 129-134 26055227-10 2016 Furthermore, paliperidone significantly reversed MK-801 induced increase of SIRT1 and decrease of miR-134 expression (both p < 0.05). Paliperidone Palmitate 13-25 sirtuin 1 Homo sapiens 76-81 26055227-12 2016 Taken together, our results demonstrated that paliperidone could protect SH-SY5Y cells against MK-801 induced neurotoxicity via inhibition of Ca(2+) influx and regulation of SIRT1/miR-134 pathway, providing a promising and potential therapeutic target for schizophrenia. Paliperidone Palmitate 46-58 sirtuin 1 Homo sapiens 174-179