PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15683552-0	2004	The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein.	Paliperidone Palmitate	35-55	phosphoglycolate phosphatase	Mus musculus	78-92	
28272498-6	2017	We confirmed that the brain disposition of risperidone and 9-hydroxy risperidone is strongly influenced by P-gp, as P-gp knockout mice displayed greater brain concentrations of these drugs than wild-type mice.	Paliperidone Palmitate	59-80	phosphoglycolate phosphatase	Mus musculus	107-111	
28272498-6	2017	We confirmed that the brain disposition of risperidone and 9-hydroxy risperidone is strongly influenced by P-gp, as P-gp knockout mice displayed greater brain concentrations of these drugs than wild-type mice.	Paliperidone Palmitate	59-80	phosphoglycolate phosphatase	Mus musculus	116-120	
18164477-2	2008	The antipsychotic drug risperidone and its active metabolite 9-hydroxyrisperidone (paliperidone) are substrates of P-gp.	Paliperidone Palmitate	61-81	phosphoglycolate phosphatase	Mus musculus	115-119	
18164477-2	2008	The antipsychotic drug risperidone and its active metabolite 9-hydroxyrisperidone (paliperidone) are substrates of P-gp.	Paliperidone Palmitate	83-95	phosphoglycolate phosphatase	Mus musculus	115-119	
27257556-10	2016	In comparison, the brain/plasma concentration ratios of risperidone and 9-hydroxy risperidone were profoundly higher in P-gp knockout mice than WT mice.	Paliperidone Palmitate	72-93	phosphoglycolate phosphatase	Mus musculus	120-124	
16118767-0	2005	P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments.	Paliperidone Palmitate	48-64	phosphoglycolate phosphatase	Mus musculus	0-14	
16118767-3	2005	Here we compared the in vitro P-gp interactions of Risp and its major metabolite, 9-OH-Risperidone (OH-Risp), with their distribution over the BBB in P-gp knock-out mice and in rats where P-gp was inhibited.	Paliperidone Palmitate	82-98	phosphoglycolate phosphatase	Mus musculus	30-34	
15683552-5	2004	These results indicate that P-gp in the blood-brain barrier significantly influences the brain concentrations of risperidone and 9-OH-risperidone by limiting their CNS access.	Paliperidone Palmitate	129-145	phosphoglycolate phosphatase	Mus musculus	28-32