PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26068927-1 2015 BACKGROUND AND OBJECTIVE: The oral direct factor Xa inhibitor edoxaban is a P-glycoprotein (P-gp) substrate metabolized via carboxylesterase-1 and cytochrome P450 (CYP) 3A4/5. edoxaban 62-70 carboxylesterase 1 Homo sapiens 124-142