PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28337024-0 2017 Angiotensin II promotes the anticoagulant effects of rivaroxaban via angiotensin type 2 receptor signaling in mice. Rivaroxaban 53-64 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-14 28337024-4 2017 In this study, we investigate whether AngII influences anticoagulant effects of rivaroxaban by using an experimental mouse model with type 2 diabetes mellitus and advanced glycation end product (AGE)-exposed human umbilical vein endothelial cells (HUVECs). Rivaroxaban 80-91 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 38-43 28337024-5 2017 We found that AngII promoted the anticoagulant effects of rivaroxaban in KKAy mice. Rivaroxaban 58-69 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 14-19 28337024-7 2017 Angiotensin type 2 receptor (AT2R) and Mas antagonists attenuated the AngII-enhanced anticoagulant action of rivaroxaban in vivo, and abolished the increased endothelial TFPI expression and activity. Rivaroxaban 109-120 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 70-75 28337024-10 2017 Our data suggest that the anticoagulant effects of rivaroxaban are promoted by AngII via AT2R and Mas signaling. Rivaroxaban 51-62 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 79-84 32521334-0 2020 Rivaroxaban ameliorates angiotensin II-induced cardiac remodeling by attenuating TXNIP/Trx2 interaction in KKAy mice. Rivaroxaban 0-11 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 24-38 32521334-2 2020 Based on those previous research results, we detected the roles of Rivaroxaban in Angiotensin II (AngII)-induced cardiac remodeling with KKAy mice and unraveled the underlying mechanisms. Rivaroxaban 67-78 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 82-96 32521334-2 2020 Based on those previous research results, we detected the roles of Rivaroxaban in Angiotensin II (AngII)-induced cardiac remodeling with KKAy mice and unraveled the underlying mechanisms. Rivaroxaban 67-78 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 98-103 32521334-3 2020 Rivaroxaban inhibited cardiac fibrosis and hypertrophy in AngII-infused KKAy mice. Rivaroxaban 0-11 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 58-63 32521334-9 2020 Thus, Rivaroxaban ameliorates AngII-induced cardiac remodeling via the suppression of TXNIP signaling in KKAy mice, providing novel mechanism underlying the protective roles of Rivaroxaban against cardiac damage. Rivaroxaban 6-17 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 30-35 32521334-9 2020 Thus, Rivaroxaban ameliorates AngII-induced cardiac remodeling via the suppression of TXNIP signaling in KKAy mice, providing novel mechanism underlying the protective roles of Rivaroxaban against cardiac damage. Rivaroxaban 177-188 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 30-35