PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34526906-0	2021	Corrigendum: 7-Ethyl-10-Hydroxycamptothecin, A DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth.	Irinotecan	13-43	bromodomain containing 4	Homo sapiens	87-91	
33995089-0	2021	Case Report: 7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth.	Irinotecan	13-43	bromodomain containing 4	Homo sapiens	87-91	
33995089-2	2021	In our study, SN-38 was characterized as a potent and reversible BRD4 inhibitor [IC50 = 660.2 nM against BRD4 (BD1) and IC50 = 547.7 nM against BRD4 (BD2)] in biochemical assay using drug repurposing strategy.	Irinotecan	14-19	bromodomain containing 4	Homo sapiens	65-69	
33995089-2	2021	In our study, SN-38 was characterized as a potent and reversible BRD4 inhibitor [IC50 = 660.2 nM against BRD4 (BD1) and IC50 = 547.7 nM against BRD4 (BD2)] in biochemical assay using drug repurposing strategy.	Irinotecan	14-19	bromodomain containing 4	Homo sapiens	105-109	
33995089-2	2021	In our study, SN-38 was characterized as a potent and reversible BRD4 inhibitor [IC50 = 660.2 nM against BRD4 (BD1) and IC50 = 547.7 nM against BRD4 (BD2)] in biochemical assay using drug repurposing strategy.	Irinotecan	14-19	bromodomain containing 4	Homo sapiens	105-109	
33995089-3	2021	Additional cellular assay suggested that SN-38 can bind BRD4 in human leukemic cell K562 and inhibit cell growth with IC50 = 0.2798 muM in a BRD4 dependent manner partially.	Irinotecan	41-46	bromodomain containing 4	Homo sapiens	56-60	
33995089-3	2021	Additional cellular assay suggested that SN-38 can bind BRD4 in human leukemic cell K562 and inhibit cell growth with IC50 = 0.2798 muM in a BRD4 dependent manner partially.	Irinotecan	41-46	bromodomain containing 4	Homo sapiens	141-145	
33995089-4	2021	Additionally, mechanism study indicated that SN-38 can induce the accumulation of BRD4 substrate c-Myc and cleavage of caspase 3.	Irinotecan	45-50	bromodomain containing 4	Homo sapiens	82-86	
33995089-5	2021	In sum, our findings identified BRD4 as a new target of SN-38 and reveals SN-38 as a modifier of histone acetylation reader for the first time, which may provide a new insight for further optimization of dual target inhibitor.	Irinotecan	56-61	bromodomain containing 4	Homo sapiens	32-36