PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26718653-6	2016	Recombinant human AADAC was shown to catalyze prasugrel hydrolysis with a CLint value of 50.0 +- 1.2 ml/min/mg protein with a similar Km value to human intestinal and liver microsomes, whereas the CLint values of human CES1 and CES2 were 4.6 +- 0.1 and 6.6 +- 0.3 ml/min/mg protein, respectively.	Prasugrel Hydrochloride	46-55	carboxylesterase 1	Homo sapiens	219-223	
18372401-0	2008	The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2.	Prasugrel Hydrochloride	25-34	carboxylesterase 1	Homo sapiens	79-104	
18372401-3	2008	The presumed role of the human liver- and intestinal-dominant carboxylesterases, hCE1 and hCE2, respectively, in the conversion of prasugrel to R-95913 was determined using expressed and purified enzymes.	Prasugrel Hydrochloride	131-140	carboxylesterase 1	Homo sapiens	81-85	
18372401-5	2008	Hydrolysis of prasugrel by hCE1 showed Michaelis-Menten kinetics yielding an apparent K(m) of 9.25 microM and an apparent V(max) of 0.725 nmol product/min/microg protein.	Prasugrel Hydrochloride	14-23	carboxylesterase 1	Homo sapiens	27-31