PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24672435-1 2014 The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARalpha receptors, and their presence requires the activation of a specific phospholipase D (NAPE-PLD) associated with intracellular Ca(2+) fluxes. oleoylethanolamide 32-50 peroxisome proliferator activated receptor alpha Rattus norvegicus 127-136 24829501-1 2014 The endogenous lipid messenger oleoylethanolamide (OEA) inhibits eating and modulates fat metabolism supposedly through the activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) and vagal sensory fibers. oleoylethanolamide 31-49 peroxisome proliferator activated receptor alpha Rattus norvegicus 138-186 24829501-1 2014 The endogenous lipid messenger oleoylethanolamide (OEA) inhibits eating and modulates fat metabolism supposedly through the activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) and vagal sensory fibers. oleoylethanolamide 31-49 peroxisome proliferator activated receptor alpha Rattus norvegicus 188-197 24829501-1 2014 The endogenous lipid messenger oleoylethanolamide (OEA) inhibits eating and modulates fat metabolism supposedly through the activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) and vagal sensory fibers. oleoylethanolamide 51-54 peroxisome proliferator activated receptor alpha Rattus norvegicus 138-186 24829501-1 2014 The endogenous lipid messenger oleoylethanolamide (OEA) inhibits eating and modulates fat metabolism supposedly through the activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) and vagal sensory fibers. oleoylethanolamide 51-54 peroxisome proliferator activated receptor alpha Rattus norvegicus 188-197 24672435-1 2014 The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARalpha receptors, and their presence requires the activation of a specific phospholipase D (NAPE-PLD) associated with intracellular Ca(2+) fluxes. oleoylethanolamide 52-55 peroxisome proliferator activated receptor alpha Rattus norvegicus 127-136 24465540-1 2014 Dietary fat-derived lipid oleoylethanolamide (OEA) has shown to modulate lipid metabolism through a peroxisome proliferator-activated receptor-alpha (PPAR-alpha)-mediated mechanism. oleoylethanolamide 26-44 peroxisome proliferator activated receptor alpha Rattus norvegicus 100-148 24169105-1 2014 Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor alpha (PPARalpha) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological disorder models, including stroke and Parkinson"s disease. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 46-94 24169105-1 2014 Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor alpha (PPARalpha) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological disorder models, including stroke and Parkinson"s disease. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 96-105 24169105-1 2014 Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor alpha (PPARalpha) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological disorder models, including stroke and Parkinson"s disease. oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 46-94 24169105-1 2014 Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor alpha (PPARalpha) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological disorder models, including stroke and Parkinson"s disease. oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 96-105 24169105-14 2014 In conclusion, systemic OEA protects the nigrostriatal circuit from 6-OH-DA-induced neurotoxicity through a PPARalpha-dependent mechanism. oleoylethanolamide 24-27 peroxisome proliferator activated receptor alpha Rattus norvegicus 108-117 24465540-1 2014 Dietary fat-derived lipid oleoylethanolamide (OEA) has shown to modulate lipid metabolism through a peroxisome proliferator-activated receptor-alpha (PPAR-alpha)-mediated mechanism. oleoylethanolamide 26-44 peroxisome proliferator activated receptor alpha Rattus norvegicus 150-160 24465540-1 2014 Dietary fat-derived lipid oleoylethanolamide (OEA) has shown to modulate lipid metabolism through a peroxisome proliferator-activated receptor-alpha (PPAR-alpha)-mediated mechanism. oleoylethanolamide 46-49 peroxisome proliferator activated receptor alpha Rattus norvegicus 100-148 24465540-1 2014 Dietary fat-derived lipid oleoylethanolamide (OEA) has shown to modulate lipid metabolism through a peroxisome proliferator-activated receptor-alpha (PPAR-alpha)-mediated mechanism. oleoylethanolamide 46-49 peroxisome proliferator activated receptor alpha Rattus norvegicus 150-160 24159189-2 2014 Oleoylethanolamide (OEA) can inhibit feeding and stimulate lipolysis by activating peroxisome proliferator-activating receptor-alpha (PPARalpha) in white adipose tissue (WAT). oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 134-143 24159189-7 2014 Regarding eWAT, CL316243 and OEA treatment elevated levels of the thermogenic factors PPARalpha and UCP1, reduced p38-MAPK phosphorylation, and promoted brown-like features in the white adipocytes: the mitochondrial (Cox4i1, Cox4i2) and BAT (Fgf21, Prdm16) genes were overexpressed in eWAT. oleoylethanolamide 29-32 peroxisome proliferator activated receptor alpha Rattus norvegicus 86-95 24159189-2 2014 Oleoylethanolamide (OEA) can inhibit feeding and stimulate lipolysis by activating peroxisome proliferator-activating receptor-alpha (PPARalpha) in white adipose tissue (WAT). oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 134-143 23959001-2 2013 This effect, which requires intact vagal fibers and intestinal PPAR-alpha receptors, is coupled to the increase of c-fos and oxytocin mRNA expression in neurons of the paraventricular nucleus (PVN) and is prevented by the intracerebroventricular administration of a selective oxytocin antagonist, thus suggesting a necessary role of oxytocinergic neurotransmission in the pro-satiety effect of OEA. oleoylethanolamide 394-397 peroxisome proliferator activated receptor alpha Rattus norvegicus 63-73 17228882-0 2007 Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation. oleoylethanolamide 27-45 peroxisome proliferator activated receptor alpha Rattus norvegicus 91-100 22239952-16 2012 It is suggested that the increase of PEA and OEA plasma levels may induce DHA biosynthesis via peroxisome proliferator-activated receptor (PPAR) alpha activation, protecting brain tissue from ischemia/reperfusion injury. oleoylethanolamide 45-48 peroxisome proliferator activated receptor alpha Rattus norvegicus 95-137 22239952-16 2012 It is suggested that the increase of PEA and OEA plasma levels may induce DHA biosynthesis via peroxisome proliferator-activated receptor (PPAR) alpha activation, protecting brain tissue from ischemia/reperfusion injury. oleoylethanolamide 45-48 peroxisome proliferator activated receptor alpha Rattus norvegicus 139-143 20353771-5 2010 PEA and OEA can activate several different receptors and inhibit some ion channels, e.g., PPARalpha, vanilloid receptor, K(+) channels (Kv4.3, Kv1.5), and OEA can activate GPR119 and inhibit ceramidases. oleoylethanolamide 8-11 peroxisome proliferator activated receptor alpha Rattus norvegicus 90-99 19345745-0 2009 Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 41-51 19345745-4 2009 OEA is a PPAR-alpha agonist, and recently it has been found that OEA is an endogenous ligand of an orphan receptor. oleoylethanolamide 0-3 peroxisome proliferator activated receptor alpha Rattus norvegicus 9-19 19345745-13 2009 In summary, OEA inhibits insulin metabolic and mitogenic signalling by activation of JNK and p38 MAPK via PPAR-alpha. oleoylethanolamide 12-15 peroxisome proliferator activated receptor alpha Rattus norvegicus 106-116 19416833-4 2009 OEA mediates fat-induced satiety by engaging type-alpha peroxisome proliferator-activated receptors (PPAR-alpha) in the gut and recruiting local afferents of the vagus nerve. oleoylethanolamide 0-3 peroxisome proliferator activated receptor alpha Rattus norvegicus 101-111 18434444-8 2008 Enhanced OEA production in Ad-NPLD-injected animals was temporally associated with increased expression of two PPAR-alpha target genes (PPAR-alpha and CD36) and with decreased food intake. oleoylethanolamide 9-12 peroxisome proliferator activated receptor alpha Rattus norvegicus 111-121 18434444-8 2008 Enhanced OEA production in Ad-NPLD-injected animals was temporally associated with increased expression of two PPAR-alpha target genes (PPAR-alpha and CD36) and with decreased food intake. oleoylethanolamide 9-12 peroxisome proliferator activated receptor alpha Rattus norvegicus 136-146 17467748-2 2008 While anandamide, a cannabinoid CB1 receptor agonist, promotes feeding and lipogenesis, oleoylethanolamide, an endogenous agonist of peroxisome proliferator activated receptor alpha (PPAR-alpha), decreases food intake and activates lipid mobilization and oxidation. oleoylethanolamide 88-106 peroxisome proliferator activated receptor alpha Rattus norvegicus 133-181 17467748-2 2008 While anandamide, a cannabinoid CB1 receptor agonist, promotes feeding and lipogenesis, oleoylethanolamide, an endogenous agonist of peroxisome proliferator activated receptor alpha (PPAR-alpha), decreases food intake and activates lipid mobilization and oxidation. oleoylethanolamide 88-106 peroxisome proliferator activated receptor alpha Rattus norvegicus 183-193 22736460-0 2012 Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARalpha agonist, reduces body weight gain and plasma cholesterol in rats. oleoylethanolamide 22-40 peroxisome proliferator activated receptor alpha Rattus norvegicus 50-59 19070629-1 2009 Oleoylethanolamide (OEA), agonist of nuclear PPAR-alpha receptors and antagonist of vanilloid TRPV1 receptors, has been reported to show cytoprotective properties. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 45-55 19070629-1 2009 Oleoylethanolamide (OEA), agonist of nuclear PPAR-alpha receptors and antagonist of vanilloid TRPV1 receptors, has been reported to show cytoprotective properties. oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 45-55 17228882-1 2007 Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARalpha) activators. oleoylethanolamide 98-116 peroxisome proliferator activated receptor alpha Rattus norvegicus 178-226 33037452-1 2021 RATIONALE: N-acylethanolamine acid amidase (NAAA) is an intracellular cysteine hydrolase that terminates the biological actions of oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), two endogenous lipid-derived agonists of the nuclear receptor, and peroxisome proliferator-activated receptor-alpha. oleoylethanolamide 131-149 peroxisome proliferator activated receptor alpha Rattus norvegicus 256-304 16702440-1 2006 Oleoylethanolamide (OEA) is an endogenous lipid mediator that reduces food intake, promotes lipolysis, and decreases body weight gain in rodents by activating peroxisome proliferator-activated receptor-alpha (PPAR-alpha). oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 159-207 16702440-1 2006 Oleoylethanolamide (OEA) is an endogenous lipid mediator that reduces food intake, promotes lipolysis, and decreases body weight gain in rodents by activating peroxisome proliferator-activated receptor-alpha (PPAR-alpha). oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 209-219 16702440-1 2006 Oleoylethanolamide (OEA) is an endogenous lipid mediator that reduces food intake, promotes lipolysis, and decreases body weight gain in rodents by activating peroxisome proliferator-activated receptor-alpha (PPAR-alpha). oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 159-207 16702440-1 2006 Oleoylethanolamide (OEA) is an endogenous lipid mediator that reduces food intake, promotes lipolysis, and decreases body weight gain in rodents by activating peroxisome proliferator-activated receptor-alpha (PPAR-alpha). oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 209-219 16702440-3 2006 In the present study, we describe OEA analogs that resist enzymatic hydrolysis, activate PPAR-alpha with high potency in vitro, and persistently reduce feeding when administered in vivo either parenterally or orally. oleoylethanolamide 34-37 peroxisome proliferator activated receptor alpha Rattus norvegicus 89-99 15879057-1 2005 Oleoylethanolamide (OEA), a lipid synthesized in the intestine, reduces food intake and stimulates lipolysis through peroxisome proliferator-activated receptor-alpha. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 117-165 15879057-1 2005 Oleoylethanolamide (OEA), a lipid synthesized in the intestine, reduces food intake and stimulates lipolysis through peroxisome proliferator-activated receptor-alpha. oleoylethanolamide 20-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 117-165 15879057-8 2005 This likely underlies the reduced heat expenditure and sodium consumption observed after OEA injection, which disappeared within 1 h. The effects of OEA on motor activity were similar to those of the TRPV1 agonist capsaicin and were also observed with the peroxisome proliferator-activated receptor-alpha agonist Wy-14643. oleoylethanolamide 89-92 peroxisome proliferator activated receptor alpha Rattus norvegicus 256-304 15879057-8 2005 This likely underlies the reduced heat expenditure and sodium consumption observed after OEA injection, which disappeared within 1 h. The effects of OEA on motor activity were similar to those of the TRPV1 agonist capsaicin and were also observed with the peroxisome proliferator-activated receptor-alpha agonist Wy-14643. oleoylethanolamide 149-152 peroxisome proliferator activated receptor alpha Rattus norvegicus 256-304 15910890-0 2005 Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 34-44 15910890-4 2005 Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. oleoylethanolamide 0-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 96-106 15910890-22 2005 In the present study, we report that subchronic OEA treatment (5mgkg(-1), intraperitoneally, i.p., once daily for two weeks) in Zucker rats initiates transcription of PPAR-alpha and other PPAR-alpha target genes, including fatty-acid translocase (FAT/CD36), liver fatty-acid binding protein (L-FABP), and uncoupling protein-2 (UCP-2). oleoylethanolamide 48-51 peroxisome proliferator activated receptor alpha Rattus norvegicus 167-177 15910890-22 2005 In the present study, we report that subchronic OEA treatment (5mgkg(-1), intraperitoneally, i.p., once daily for two weeks) in Zucker rats initiates transcription of PPAR-alpha and other PPAR-alpha target genes, including fatty-acid translocase (FAT/CD36), liver fatty-acid binding protein (L-FABP), and uncoupling protein-2 (UCP-2). oleoylethanolamide 48-51 peroxisome proliferator activated receptor alpha Rattus norvegicus 188-198 33037452-1 2021 RATIONALE: N-acylethanolamine acid amidase (NAAA) is an intracellular cysteine hydrolase that terminates the biological actions of oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), two endogenous lipid-derived agonists of the nuclear receptor, and peroxisome proliferator-activated receptor-alpha. oleoylethanolamide 151-154 peroxisome proliferator activated receptor alpha Rattus norvegicus 256-304 30439418-3 2019 An alternative indirect way to activate PPARalpha is inhibition of N-acylethanolamine acid amidase (NAAA), one of the major hydrolyzing enzyme for its endogenous agonists palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). oleoylethanolamide 203-221 peroxisome proliferator activated receptor alpha Rattus norvegicus 40-49 32922296-8 2020 Administration of OEA produced significant improvement in a colitis model, possibly by inhibiting the nuclear factor kappa B signaling pathway through PPAR-alpha receptors. oleoylethanolamide 18-21 peroxisome proliferator activated receptor alpha Rattus norvegicus 151-161 30496754-7 2019 Interestingly, OEA abrogated the impaired effects of ethanol on PPARalpha-positive cell population and NSPC proliferation and maturation. oleoylethanolamide 15-18 peroxisome proliferator activated receptor alpha Rattus norvegicus 64-73 30439418-3 2019 An alternative indirect way to activate PPARalpha is inhibition of N-acylethanolamine acid amidase (NAAA), one of the major hydrolyzing enzyme for its endogenous agonists palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). oleoylethanolamide 223-226 peroxisome proliferator activated receptor alpha Rattus norvegicus 40-49 29388342-1 2018 The endogenous peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist Oleoylethanolamide (OEA) inhibits eating in rodents, mainly by delaying the onset of meals. oleoylethanolamide 85-103 peroxisome proliferator activated receptor alpha Rattus norvegicus 15-63 30251159-6 2018 This effect was strongly correlated with inhibition of brain FAAH activity (r2 = 1.0) and was accompanied by increased brain levels of three FAAH substrates: the endocannabinoid anandamide and the endogenous peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonists, oleoylethanolamide (OEA), and palmitoylethanolamide (PEA). oleoylethanolamide 280-298 peroxisome proliferator activated receptor alpha Rattus norvegicus 208-256 30251159-6 2018 This effect was strongly correlated with inhibition of brain FAAH activity (r2 = 1.0) and was accompanied by increased brain levels of three FAAH substrates: the endocannabinoid anandamide and the endogenous peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonists, oleoylethanolamide (OEA), and palmitoylethanolamide (PEA). oleoylethanolamide 300-303 peroxisome proliferator activated receptor alpha Rattus norvegicus 208-256 29388342-1 2018 The endogenous peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist Oleoylethanolamide (OEA) inhibits eating in rodents, mainly by delaying the onset of meals. oleoylethanolamide 85-103 peroxisome proliferator activated receptor alpha Rattus norvegicus 65-75 29388342-1 2018 The endogenous peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist Oleoylethanolamide (OEA) inhibits eating in rodents, mainly by delaying the onset of meals. oleoylethanolamide 105-108 peroxisome proliferator activated receptor alpha Rattus norvegicus 15-63 29388342-1 2018 The endogenous peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist Oleoylethanolamide (OEA) inhibits eating in rodents, mainly by delaying the onset of meals. oleoylethanolamide 105-108 peroxisome proliferator activated receptor alpha Rattus norvegicus 65-75 29290921-6 2017 In RYGB rats, high fat diet (HFD) led to increased production of OEA that activated the intestinal peroxisome proliferation activator receptors-alpha (PPARalpha). oleoylethanolamide 65-68 peroxisome proliferator activated receptor alpha Rattus norvegicus 151-160 29290921-7 2017 In RYGB rats, activation of PPARalpha by OEA was accompanied by enhanced dopamine neurotransmission in the dorsal striatum and reduced preference for HFD. oleoylethanolamide 41-44 peroxisome proliferator activated receptor alpha Rattus norvegicus 28-37 26578900-10 2015 Since, NAPE-PLD and PPARalpha are proteins that participate in the biochemical process of AEs, specially the neuroprotective oleoylethanolamide, these results suggest that PA dysregulates this system. oleoylethanolamide 125-143 peroxisome proliferator activated receptor alpha Rattus norvegicus 20-29 27646482-2 2016 The PPARalpha recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. oleoylethanolamide 77-95 peroxisome proliferator activated receptor alpha Rattus norvegicus 4-13 27646482-2 2016 The PPARalpha recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. oleoylethanolamide 97-100 peroxisome proliferator activated receptor alpha Rattus norvegicus 4-13 27646482-5 2016 We report that after 6h of TSD activation of PPARalpha by pharmacological systemic administration of OEA (10, 20 or 30mg/Kg, i.p.) oleoylethanolamide 101-104 peroxisome proliferator activated receptor alpha Rattus norvegicus 45-54 26769918-1 2016 The endogenous lipid amides, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), exert marked antinociceptive and anti-inflammatory effects in animal models by engaging nuclear peroxisome proliferator-activated receptor-alpha. oleoylethanolamide 61-79 peroxisome proliferator activated receptor alpha Rattus norvegicus 183-231 26769918-1 2016 The endogenous lipid amides, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), exert marked antinociceptive and anti-inflammatory effects in animal models by engaging nuclear peroxisome proliferator-activated receptor-alpha. oleoylethanolamide 81-84 peroxisome proliferator activated receptor alpha Rattus norvegicus 183-231 28579484-7 2017 Since NAPE-PLD and PPARalpha take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. oleoylethanolamide 110-128 peroxisome proliferator activated receptor alpha Rattus norvegicus 19-28 25775474-6 2015 In addition, we found an increase of oleoylethanolamide, an avid PPAR alpha ligand, in liver, muscle and brain, associated to higher levels of its precursor oleic acid in liver and muscle, probably derived by elongation and further delta 9 desaturation of PA. oleoylethanolamide 37-55 peroxisome proliferator activated receptor alpha Rattus norvegicus 65-75 25748831-5 2015 Further study demonstrated that treatment with OEA markedly increased the expressions of brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptors alpha (PPARalpha). oleoylethanolamide 47-50 peroxisome proliferator activated receptor alpha Rattus norvegicus 185-194