PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21532155-0	2011	Nateglinide stimulates glucagon-like peptide-1 release by human intestinal L cells via a K(ATP) channel-independent mechanism.	Nateglinide	0-11	glucagon	Homo sapiens	23-46	
21532155-2	2011	In this study, we investigated the effect of nateglinide on GLP-1 release in vivo and in vitro.	Nateglinide	45-56	glucagon	Homo sapiens	60-65	
21532155-5	2011	Nateglinide stimulated GLP-1 release in a concentration-dependent manner from 500 microM, along with transient elevation of the intracellular calcium level.	Nateglinide	0-11	glucagon	Homo sapiens	23-28	
21532155-8	2011	On the other hand, capsazepine significantly inhibited the promotion of GLP-1 release by nateglinide in a concentration-dependent manner.	Nateglinide	89-100	glucagon	Homo sapiens	72-77	
21532155-9	2011	These findings indicate that nateglinide directly stimulates GLP-1 release by intestinal L cells in a K(ATP) channel-independent manner.	Nateglinide	29-40	glucagon	Homo sapiens	61-66	
21532155-10	2011	A novel target of nateglinide may be involved in increasing intracellular calcium to stimulate GLP-1 release, e.g., the transient receptor potential channels.	Nateglinide	18-29	glucagon	Homo sapiens	95-100	
21532155-11	2011	Taken together, the present findings indicate that promotion of GLP-1 release from intestinal L cells may be another important mechanism by which nateglinide restores early-phase insulin secretion and regulates postprandial glucose metabolism.	Nateglinide	146-157	glucagon	Homo sapiens	64-69	
17003289-0	2006	Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide.	Nateglinide	117-128	glucagon	Homo sapiens	11-34	
17003289-3	2006	GLP-1 similarly augmented the K(ATP) channel-independent insulin-releasing effects of tolbutamide, glibenclamide or nateglinide.	Nateglinide	116-127	glucagon	Homo sapiens	0-5	
26417414-7	2015	As expected, the change in active glucagon like peptide-1 was significantly higher after a single-dose of sitagliptin than nateglinide.	Nateglinide	123-134	glucagon	Homo sapiens	34-57	
25461479-6	2015	The absolute total concentrations of secreted GLP-1 peptides at baseline and after stimulation with nateglinide, glucose, and sucralose were 167.3, 498.9, 238.3, and 143.1 pM, respectively.	Nateglinide	100-111	glucagon	Homo sapiens	46-51