PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33390555-2 2021 Nateglinide (NTG) was utilized as a model compound, since it is a hepatically-metabolized compound and its metabolism is mainly mediated by CYP 2C11 enzyme. Nateglinide 0-11 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 140-148 33390555-8 2021 These findings suggest that inflammation occurring in peripheral tissues brings about a decrease in hepatic NTG metabolism by suppressing the hepatic expression of CYP2C11 protein, causing an alteration of the plasma concentration profile of NTG with its impaired elimination. Nateglinide 108-111 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 164-171 33390555-8 2021 These findings suggest that inflammation occurring in peripheral tissues brings about a decrease in hepatic NTG metabolism by suppressing the hepatic expression of CYP2C11 protein, causing an alteration of the plasma concentration profile of NTG with its impaired elimination. Nateglinide 242-245 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 164-171