PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34772419-0 2021 PPARD rs2016520 (T/C) and NOS1AP rs12742393 (A/C) polymorphisms affect therapeutic efficacy of nateglinide in Chinese patients with type 2 diabetes mellitus. Nateglinide 95-106 peroxisome proliferator activated receptor delta Homo sapiens 0-5 34772419-1 2021 BACKGROUND: Genetic polymorphisms in the PPARD and NOS1AP is associated with type 2 diabetes mellitus (T2DM); however, there is no evidence about its impact on the therapeutic efficacy of nateglinide. Nateglinide 188-199 peroxisome proliferator activated receptor delta Homo sapiens 41-46 34772419-2 2021 This study was designed to investigate a potential association of PPARD rs2016520 (T/C) and NOS1AP rs12742393 (A/C) polymorphisms with efficacy of nateglinide in newly diagnosed Chinese patients with type 2 diabetes mellitus (T2DM). Nateglinide 147-158 peroxisome proliferator activated receptor delta Homo sapiens 66-71 34772419-6 2021 RESULTS: After nateglinide treatment for 8 consecutive weeks, patients with at least one C allele of PPARD rs2016520 showed a smaller decrease in post plasma glucose (PPG), homeostasis model assessment for beta cell function (HOMA-B) than those with the TT genotype did (P < 0.05). Nateglinide 15-26 peroxisome proliferator activated receptor delta Homo sapiens 101-106 34772419-9 2021 CONCLUSIONS: The PPARD rs2016520 and NOS1AP rs12742393 polymorphisms were associated with nateglinide monotherapy efficacy in Chinese patients with newly diagnosed T2DM. Nateglinide 90-101 peroxisome proliferator activated receptor delta Homo sapiens 17-22