PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34025070-16 2021 Moreover, SB203580 significantly reduced the pulmonary P-p38, NFkappaB, P-signal transducer and activator of transcription-3 and Myd88 levels but increased the IkappaB and HO-1 levels. SB 203580 10-18 heme oxygenase 1 Homo sapiens 172-176 34135317-11 2021 By contrast, downregulation of p38-MAPK by SB203580 decreased intracellular ROS level and enhanced the expression of HO-1. SB 203580 43-51 heme oxygenase 1 Homo sapiens 117-121 25341814-7 2014 The HO-1 activity and HO-1 expression level were significantly higher after atorvastatin treatment than before atorvastatin treatment and attenuated by SB203580 and PD98059 but not by SP600125, suggesting that the ERK and p38 mitogen-activated protein kinase (MAPK) pathways participate in regulating the above-mentioned effects of atorvastatin. SB 203580 152-160 heme oxygenase 1 Homo sapiens 4-8 29656184-8 2018 Blockage of p38 phosphorylation with its specific inhibitor SB203580 or by transfection with p38 siRNA restrained ropivacaine-stimulated HO-1 expression. SB 203580 60-68 heme oxygenase 1 Homo sapiens 137-141 29796178-4 2018 Induction of HO-1 protein expression was mimicked by SB203580, another p38 MAPK inhibitor, but not by SB202474, an inactive structural analogue of p38 MAPK inhibitors. SB 203580 53-61 heme oxygenase 1 Homo sapiens 13-17 29796178-5 2018 HO-1 induction by both SB202190 and SB203580 was also demonstrated by analysis of mRNA expression. SB 203580 36-44 heme oxygenase 1 Homo sapiens 0-4 25341814-7 2014 The HO-1 activity and HO-1 expression level were significantly higher after atorvastatin treatment than before atorvastatin treatment and attenuated by SB203580 and PD98059 but not by SP600125, suggesting that the ERK and p38 mitogen-activated protein kinase (MAPK) pathways participate in regulating the above-mentioned effects of atorvastatin. SB 203580 152-160 heme oxygenase 1 Homo sapiens 22-26 24932697-10 2014 We also demonstrated that the specific p38 MAPK inhibitor, SB203580, concentration-dependently blocked on gastrodin-induced HO-1 expression, and meanwhile SB203580 reversed the protective effect of gastrodin against MPP(+)-induced cell death. SB 203580 59-67 heme oxygenase 1 Homo sapiens 124-128 20515663-6 2010 The increase of HO-1 protein was suppressed by a p38 MAPK inhibitor SB203580, and early activation of p38 MAPK after thrombin treatment was observed in neurons and microglia in the striatum. SB 203580 68-76 heme oxygenase 1 Homo sapiens 16-20 23412940-6 2013 HO-1 expression was downregulated in cells treated with SB203580 and RAPA. SB 203580 56-64 heme oxygenase 1 Homo sapiens 0-4 23412940-7 2013 HO-1 overexpression inhibited apoptosis and induced G2/M arrest in SB203580 and RAPA-treated cells. SB 203580 67-75 heme oxygenase 1 Homo sapiens 0-4 23536693-4 2013 Specific inhibitors of mitogen-activated protein kinases (MAPKs), SB203580, PD98059, and SP600125, significantly abolished HO-1 expression. SB 203580 66-74 heme oxygenase 1 Homo sapiens 123-127 22137262-5 2012 Pretreatment of HAEC with SB203580 (p38 MAPK inhibitor) or siRNA knockdown of p38 MAPK completely blocked EGCG-stimulated induction of HO-1. SB 203580 26-34 heme oxygenase 1 Homo sapiens 135-139 15504750-9 2004 Ritonavir-induced HO-1 protein was suppressed by SB203580 or SB202190 and preceded by immediate upregulation of cellular c-Fos and c-Jun protein levels. SB 203580 49-57 heme oxygenase 1 Homo sapiens 18-22 19548360-5 2008 The increases in reactive species and HO-1 protein are inhibited by agonists of glucocorticoid receptors (GR), such as RU28362, prednisolone, and dexamethasone, as well as by N-acetyl-L-cysteine and SB203580 (a p38 inhibitor), suggesting a role of GR in NF-induced increases in reactive species and HO-1. SB 203580 199-207 heme oxygenase 1 Homo sapiens 38-42 17277740-12 2007 Inhibitors of the mitogen-activated protein kinase (p38MAPK; SB203580) and Jun N-terminal kinase (JNK; SP600125) pathways inhibited vitreous-induction of HO-1. SB 203580 61-69 heme oxygenase 1 Homo sapiens 154-158 16123320-10 2005 Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE. SB 203580 18-26 heme oxygenase 1 Homo sapiens 98-102 16123320-10 2005 Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE. SB 203580 18-26 heme oxygenase 1 Homo sapiens 172-176 12878207-7 2003 Pretreatment with N-acetylcysteine, PD 98059, and SB 203580 decreased HO-1 upregulation in spermine NONOate-treated cells. SB 203580 50-59 heme oxygenase 1 Homo sapiens 70-74 15158123-7 2004 In addition, the induction of COX-2 and HO-1 expression by TGD was prevented by pretreatment with NAC or SB203580, a p38 MAPK inhibitor. SB 203580 105-113 heme oxygenase 1 Homo sapiens 40-44 14731112-7 2004 Antioxidant N -acetylcysteine and SB203580, an antioxidant and inhibitor of p38 MAPK (mitogen-activated protein kinase), abolished MG132-inducible HO-1 expression. SB 203580 34-42 heme oxygenase 1 Homo sapiens 147-151 14647439-8 2004 The levels of HO-1 and p21 induced were significantly inhibited by p38 mitogen-activated protein kinase (p38 MAPK) inhibitor (SB203580) and extracellular-regulated kinase (ERK) inhibitor (PD098059). SB 203580 126-134 heme oxygenase 1 Homo sapiens 14-18 33808635-8 2021 Moreover, SB203580, a selective p38 inhibitor, reduced HO-1 mRNA expression and increased palmitate-induced oxidative stress in HepG2 cells. SB 203580 10-18 heme oxygenase 1 Homo sapiens 55-59 12376363-7 2002 A chemical inhibitor of p38 MAPK (SB-203580) abolished TGF-beta1-inducible HO-1 mRNA expression. SB 203580 34-43 heme oxygenase 1 Homo sapiens 75-79 12376363-8 2002 Both SB-203580 and expression of a dominant-negative mutant of p38 MAPK inhibited TGF-beta1-induced ho-1 gene activation, as assayed by luciferase activity of an ho-1 enhancer/luciferase fusion construct (pMHO1luc-33+SX2). SB 203580 5-14 heme oxygenase 1 Homo sapiens 100-104 11015442-8 2000 Specific inhibition of p38 MAPK activation by the pyridinyl imidazol SB203580 or through overexpression of a p38 MAPK dominant negative mutant abrogated the antiapoptotic effect of HO-1. SB 203580 69-77 heme oxygenase 1 Homo sapiens 181-185 10874044-6 2000 SB203580, an inhibitor of p38, diminishes cadmium-stimulated pE1-luc expression and HO-1 mRNA levels by up to 70-80%. SB 203580 0-8 heme oxygenase 1 Homo sapiens 84-88 10872747-5 2000 Pre-treatment of the cells with PD98059, a selective ERK pathway inhibitor, and SB203580, a p38 MAPK inhibitor, blocked the induction of HO-1 by the NO donor in a dose-dependent manner. SB 203580 80-88 heme oxygenase 1 Homo sapiens 137-141