PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16388870-6 2006 Addition of p38 MAPK inhibitor, SB-203580 and NF-kappaB inhibitor Bay 11-7082, suppressed IBDV-induced NO production and mRNA expression of iNOS, IL-8 and COX-2. SB 203580 32-41 nitric oxide synthase 2 Homo sapiens 140-144 21603852-6 2012 Furthermore, our study showed LPS-induced NO production and iNOS expression were suppressed by p38 MAPK inhibitor SB203580 pretreatment. SB 203580 114-122 nitric oxide synthase 2 Homo sapiens 60-64 20155468-6 2010 Progesterone could repress the activation of iNOS through P38MAPK pathway within PMNs (P<0.05), which could be blocked by SB203580 (P<0.01), but not by actinomycin D (P>0.05). SB 203580 125-133 nitric oxide synthase 2 Homo sapiens 45-49 18348730-12 2008 Stimulation by either dynamic compression or SB203580 in isolation reduced the IL-1beta induced iNOS expression and nitrite production. SB 203580 45-53 nitric oxide synthase 2 Homo sapiens 96-100 18348730-13 2008 However, co-stimulation with both dynamic compression and SB203580 inhibited the expression levels of iNOS and production of nitrite induced by the cytokine. SB 203580 58-66 nitric oxide synthase 2 Homo sapiens 102-106 17640998-8 2007 SB 203580 also significantly prevented cytokine-induced iNOS expression and caspase activation and thus blocked Fas-mediated apoptosis of thyroid cells sensitized by IFN-gamma/IL-1beta. SB 203580 0-9 nitric oxide synthase 2 Homo sapiens 56-60 15778452-3 2005 In human DLD-1 cells, inhibition of p38 MAPK by the compound 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580) or by overexpression of a dominant-negative p38 MAPKalpha protein resulted in a reduction of human iNOS mRNA and protein expression, whereas human iNOS promoter activity was not affected. SB 203580 61-132 nitric oxide synthase 2 Homo sapiens 243-247 15946254-3 2005 Tyrosine kinase inhibitors (genistein and tyrphostin AG126), PI3K inhibitors (wortmannin and LY 294002), and a p38 MAPK inhibitor (SB 203580) attenuated LTA-induced iNOS expression and NO release in concentration-dependent manners. SB 203580 131-140 nitric oxide synthase 2 Homo sapiens 165-169 15683746-5 2005 A tyrosine kinase inhibitor (genistein), a protein kinase C (PKC) inhibitor (Ro 31-8220), and a p38 mitogen-activated protein kinase (MAPK) inhibitor (SB 203580) all respectively suppressed chloroquine-induced iNOS expression and NO release from C6 glioma cells. SB 203580 151-160 nitric oxide synthase 2 Homo sapiens 210-214 15585341-5 2005 The JNK inhibitor SP600125 and the p38 inhibitor SB203580 independently reduced both nitrite accumulation and induction of inflammatory nitric oxide synthase (iNOS). SB 203580 49-57 nitric oxide synthase 2 Homo sapiens 159-163 15707402-7 2005 SB203580 also inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the treated islets. SB 203580 0-8 nitric oxide synthase 2 Homo sapiens 42-73 15707402-7 2005 SB203580 also inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the treated islets. SB 203580 0-8 nitric oxide synthase 2 Homo sapiens 75-79 12020969-4 2002 Treatment with SB203580, a specific inhibitor of p38 mitogen-activated protein kinases (MAPK), potently inhibited IL-1-mediated induction of iNOS and TNFalpha in cultures of human fetal astrocytes. SB 203580 15-23 nitric oxide synthase 2 Homo sapiens 141-145 15086905-5 2004 A protein tyrosine kinase inhibitor (genistein), or a p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) suppressed AGE-induced iNOS expression and nitrite release from mesangial cells. SB 203580 109-117 nitric oxide synthase 2 Homo sapiens 142-146 12390692-6 2002 When treated with SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl) imidazole], a highly specific inhibitor of p38 MAPK, significant inhibition of LPS-induced iNOS protein and mRNA expressions was observed. SB 203580 18-26 nitric oxide synthase 2 Homo sapiens 179-183 12770614-5 2003 In addition, phosphorylations of MAPKs (ERK 1/2, p38, JNK 1/2) were increased by LT. LT-induced iNOS mRNA level was inhibited by PD98059 (MEK 1/2 inhibitor), SB203580 (p38 inhibitor), and cycloheximide (a protein synthesis blocker), indicating that the phosphorylation of ERK 1/2 and p38, and on-going protein synthesis are necessary for LT-induced iNOS expression. SB 203580 158-166 nitric oxide synthase 2 Homo sapiens 96-100 12421638-0 2002 P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production. SB 203580 47-55 nitric oxide synthase 2 Homo sapiens 87-91 12421638-7 2002 Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of iNOS showed that both stimulatory and inhibitory effects of SB203580 occurred at the level of iNOS expression. SB 203580 150-158 nitric oxide synthase 2 Homo sapiens 90-94 12421638-7 2002 Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of iNOS showed that both stimulatory and inhibitory effects of SB203580 occurred at the level of iNOS expression. SB 203580 150-158 nitric oxide synthase 2 Homo sapiens 184-188 12421638-9 2002 The data show that pyridinyl imidazoles SB203580 and SB202190 have a bi-directional effect on NO production through iNOS pathway depending on the drug concentration used. SB 203580 40-48 nitric oxide synthase 2 Homo sapiens 116-120 12020969-6 2002 Interestingly, SB203580 reduced the mRNA expression for iNOS, TNFalpha, and IL-6, indicating inhibition prior to translation. SB 203580 15-23 nitric oxide synthase 2 Homo sapiens 56-60 10405759-4 1999 SB 203580, a specific inhibitor of p38 MAP kinase prevented the activation of p38 MAP kinase (IC50 = 3.3 +/- 1.4 microM, n = 3) and MAPKAP kinase-2 by LPS and reduced the induction of COX-2 by approximately 50-90%, with no significant effect upon iNOS expression. SB 203580 0-9 nitric oxide synthase 2 Homo sapiens 247-251 11311970-5 2001 The dose-dependent inhibition of NO production and iNOS mRNA expression by compound SB203580 (p38 inhibitor) suggests the participation of p38 in PKA-dependent inhibition of LPS-induced NO production and iNOS mRNA expression. SB 203580 84-92 nitric oxide synthase 2 Homo sapiens 204-208 10900231-4 2000 Our data also show that the p38 kinase pathway is specifically involved in LPS-induced NF-kappaB/Rel activation and iNOS expression because NF-kappaB/Rel DNA binding and iNOS mRNA production in the presence of a specific inhibitor of p38 kinase, SB203580, were dramatically diminished. SB 203580 246-254 nitric oxide synthase 2 Homo sapiens 116-120 11693258-7 2001 The tyrosine kinase inhibitor (genistein and tyrphostin), the Ras-farnesyl transferase inhibitor (FPT inhibitor-II), or the p38 MAPK inhibitor (SB203580) suppressed AGEs-induced iNOS expression and nitrite release from C6 glioma cells. SB 203580 144-152 nitric oxide synthase 2 Homo sapiens 178-182 11311970-5 2001 The dose-dependent inhibition of NO production and iNOS mRNA expression by compound SB203580 (p38 inhibitor) suggests the participation of p38 in PKA-dependent inhibition of LPS-induced NO production and iNOS mRNA expression. SB 203580 84-92 nitric oxide synthase 2 Homo sapiens 51-55 10849439-6 2000 Blocking p38 activity with SB203580 totally abolished the enhancing effect of hsp70 on cytokine-induced endogenous iNOS mRNA accumulation or transcription of an iNOS promoter-driven luciferase gene, while having little effect on the cytokine response observed in control cells. SB 203580 27-35 nitric oxide synthase 2 Homo sapiens 115-119 10849439-6 2000 Blocking p38 activity with SB203580 totally abolished the enhancing effect of hsp70 on cytokine-induced endogenous iNOS mRNA accumulation or transcription of an iNOS promoter-driven luciferase gene, while having little effect on the cytokine response observed in control cells. SB 203580 27-35 nitric oxide synthase 2 Homo sapiens 161-165 10586030-6 1999 However, studies using inhibitors selective for ERK (PD98059) and p38 (SB203580) show that while p38 plays an essential role in the induction of inducible NO synthase, ERK MAP kinases play only a minor role in promoting NO generation. SB 203580 71-79 nitric oxide synthase 2 Homo sapiens 145-166