PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16924668-4 2007 Sal B significantly attenuated upregulations of both MMPs as well as the LPS-induced cell migration through the inactivation of MMP-2 and MMP-9 protein synthesis as well as the downregulation of the extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun NH(2)-terminal kinase (JNK). salvianolic acid B 0-5 mitogen-activated protein kinase 1 Homo sapiens 199-240 30907511-7 2019 Notably, the Sal B induced up-expression of TAZ was blocked by U0126 (the MEK-ERK inhibitor), rather than LY294002 (the PI3K-Akt inhibitor). salvianolic acid B 13-18 mitogen-activated protein kinase 1 Homo sapiens 78-81 30907511-8 2019 Moreover, Sal B increased the p-ERK/ERK ratio to regulate the TAZ expression as well as the cell differentiation. salvianolic acid B 10-15 mitogen-activated protein kinase 1 Homo sapiens 32-35 30907511-8 2019 Moreover, Sal B increased the p-ERK/ERK ratio to regulate the TAZ expression as well as the cell differentiation. salvianolic acid B 10-15 mitogen-activated protein kinase 1 Homo sapiens 36-39 30907511-9 2019 In summary, this study suggests for the first time that Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis by activating MEK-ERK signalling pathway, which provides evidence for Sal B to be used as a potential therapeutic agent for the management of bone diseases. salvianolic acid B 56-61 mitogen-activated protein kinase 1 Homo sapiens 143-146 30907511-9 2019 In summary, this study suggests for the first time that Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis by activating MEK-ERK signalling pathway, which provides evidence for Sal B to be used as a potential therapeutic agent for the management of bone diseases. salvianolic acid B 195-200 mitogen-activated protein kinase 1 Homo sapiens 143-146 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 1 Homo sapiens 94-131 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 1 Homo sapiens 133-136 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 1 Homo sapiens 171-174