PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23243430-5	2012	Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation.	salvianolic acid B	0-5	Eph receptor B1	Rattus norvegicus	316-319	
23243430-4	2012	The results showed that Sal B and perindopril inhibited rat hepatic fibrosis and reduced expression of Ang II receptor type 1 (AT1R) and ERK activation in fibrotic liver.	salvianolic acid B	24-29	Eph receptor B1	Rattus norvegicus	137-140	
24387840-0	2014	Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats.	salvianolic acid B	0-18	Eph receptor B1	Rattus norvegicus	126-163	
20629637-0	2010	MEK/ERK pathway mediates cytoprotection of salvianolic acid B against oxidative stress-induced apoptosis in rat bone marrow stem cells.	salvianolic acid B	43-61	Eph receptor B1	Rattus norvegicus	4-7	
18091994-7	2007	On the other hand, blockage of the PI3K/Akt pathway abrogated the protective effect conferred by Sal B and potentated H(2)O(2)-induced apoptosis, suggesting that Sal B prevents H(2)O(2)-induced apoptosis predominantly through the PI3K/Akt (upstream of ERK) pathway.	salvianolic acid B	162-167	Eph receptor B1	Rattus norvegicus	252-255	
18091994-8	2007	SIGNIFICANCE: Our findings provide the first evidence that H(2)O(2) induces rCMECs apoptosis via the PI3K/MEK/ERK pathway and that Sal B protects rCMECs against H(2)O(2)-induced apoptosis through the PI3K/Akt/Raf/MEK/ERK pathway.	salvianolic acid B	131-136	Eph receptor B1	Rattus norvegicus	110-113	
18091994-8	2007	SIGNIFICANCE: Our findings provide the first evidence that H(2)O(2) induces rCMECs apoptosis via the PI3K/MEK/ERK pathway and that Sal B protects rCMECs against H(2)O(2)-induced apoptosis through the PI3K/Akt/Raf/MEK/ERK pathway.	salvianolic acid B	131-136	Eph receptor B1	Rattus norvegicus	217-220	
31603005-11	2019	The protective function of Sal-B was enabled through activating PI3K/AKT and MEK/ERK pathways.	salvianolic acid B	27-32	Eph receptor B1	Rattus norvegicus	81-84	
31603005-12	2019	These findings delineated that Sal-B protected PC-12 cells against H2O2-caused injury through ascending miR-26a via initiating PI3K/AKT and MEK/ERK pathways.	salvianolic acid B	31-36	Eph receptor B1	Rattus norvegicus	144-147	
31603005-13	2019	Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a.	salvianolic acid B	85-90	Eph receptor B1	Rattus norvegicus	190-193	
31603005-13	2019	Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a.	salvianolic acid B	85-90	Eph receptor B1	Rattus norvegicus	190-193	
17005083-6	2006	Both SAB and curcumin showed insignificant effect on the ERK expression level, but they could significantly reduce the level of phosphorylated-ERK expression, showing significant difference as compared with that in the control group (P < 0.01 and P < 0.05 respectively).	salvianolic acid B	5-8	Eph receptor B1	Rattus norvegicus	143-146	
17005083-7	2006	CONCLUSION: SAB and curcumin could significantly inhibit the proliferation, activation of HSC, and the production of type I collagen in HSC, the mechanism may be associated with their inhibition on ERK phosphorylation.	salvianolic acid B	12-15	Eph receptor B1	Rattus norvegicus	198-201	
24387840-7	2014	Moreover, SalB prolonged the I/R injury-induced activation of extracellular signal-regulated kinase (ERK), and blocking ERK activation with PD98059 partially prevented the neuroprotective effects of SalB.	salvianolic acid B	10-14	Eph receptor B1	Rattus norvegicus	62-99	
24387840-7	2014	Moreover, SalB prolonged the I/R injury-induced activation of extracellular signal-regulated kinase (ERK), and blocking ERK activation with PD98059 partially prevented the neuroprotective effects of SalB.	salvianolic acid B	10-14	Eph receptor B1	Rattus norvegicus	101-104	
24387840-7	2014	Moreover, SalB prolonged the I/R injury-induced activation of extracellular signal-regulated kinase (ERK), and blocking ERK activation with PD98059 partially prevented the neuroprotective effects of SalB.	salvianolic acid B	199-203	Eph receptor B1	Rattus norvegicus	120-123	
24387840-8	2014	CONCLUSIONS: These findings demonstrate the neuroprotective effects of SalB in a spinal cord I/R injury model and suggest that SalB-induced neuroprotection was mediated by ERK activation.	salvianolic acid B	127-131	Eph receptor B1	Rattus norvegicus	172-175