PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33845224-8	2021	Specific inhibitors of ATM (KU55933) or HSP90 (17AAG) were found to increase the Th- cytotoxicity suggesting prosurvival role of these signaling molecules in rescuing the cells from Th-toxicity.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	28-35	ATM serine/threonine kinase	Homo sapiens	23-26	
34068585-8	2021	Transcriptomic analysis showed that inhibition of ATM kinase by KU55933 induced apoptosis signaling and potentiated cisplatin-induced cytotoxicity.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	64-71	ATM serine/threonine kinase	Homo sapiens	50-53	
33742560-1	2021	Inhibitors of ataxia telangiectasia mutated (ATM), such as KU-55933 (Ku), represent a promising class of novel anticancer drugs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	59-67	ATM serine/threonine kinase	Homo sapiens	14-43	
33742560-1	2021	Inhibitors of ataxia telangiectasia mutated (ATM), such as KU-55933 (Ku), represent a promising class of novel anticancer drugs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	59-67	ATM serine/threonine kinase	Homo sapiens	45-48	
33742560-1	2021	Inhibitors of ataxia telangiectasia mutated (ATM), such as KU-55933 (Ku), represent a promising class of novel anticancer drugs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	69-71	ATM serine/threonine kinase	Homo sapiens	14-43	
33742560-1	2021	Inhibitors of ataxia telangiectasia mutated (ATM), such as KU-55933 (Ku), represent a promising class of novel anticancer drugs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	69-71	ATM serine/threonine kinase	Homo sapiens	45-48	
33338048-5	2020	We could further show that combined inhibition of thioredoxin reductase (TrxR) and ATM kinase activity, using Auranofin and KU55933 respectively, induced an increase in cellular reactive oxygen species (ROS) levels and protein oxidation in lung cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	124-131	ATM serine/threonine kinase	Homo sapiens	83-86	
33743824-2	2021	In this study, combination treatments of the HSP90 inhibitor AUY922 with either the ATR inhibitor VE821 or the ATM inhibitor KU55933 were investigated for their effectiveness in Ewing"s sarcoma cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	125-132	ATM serine/threonine kinase	Homo sapiens	111-114	
32743653-6	2020	Peripheral monocytes were cultured with an ATM-specific inhibitor (KU55933), and reactive oxygen species production in the cells was measured.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	67-74	ATM serine/threonine kinase	Homo sapiens	43-46	
32743653-10	2020	Notably, KU55933, an ATM-specific inhibitor, enhanced reactive oxygen species production by monocytes under oxidative stress.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	9-16	ATM serine/threonine kinase	Homo sapiens	21-24	
30265735-6	2018	Moreover, it was possible to suggest that the inhibitors VE-821 and KU-55933 have binding affinity for the catalytic sites of putative L. major ATR and ATM, respectively.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	68-76	ATM serine/threonine kinase	Homo sapiens	152-155	
30964658-9	2019	HN2-induced cell cycle arrest was suppressed by the ATM and DNA-PK inhibitors, KU55933 and NU7441, respectively, and to a lesser extent by VE821, an ATR inhibitor.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	79-86	ATM serine/threonine kinase	Homo sapiens	52-55	
29849127-11	2018	Further studies revealed that the functions of p62 in escin-induced DNA damage were associated with escin-induced apoptosis, and p62 knockdown combined with the ATM inhibitor KU55933 augmented escin-induced DNA damage and further increased escin-induced apoptosis.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	175-182	ATM serine/threonine kinase	Homo sapiens	161-164	
32517809-8	2020	Moreover, DCZ3301 promoted the phosphorylation of ATM, ATR, and their downstream proteins, and these responses were blocked by the ATM specific inhibitor KU55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	154-161	ATM serine/threonine kinase	Homo sapiens	50-53	
32517809-8	2020	Moreover, DCZ3301 promoted the phosphorylation of ATM, ATR, and their downstream proteins, and these responses were blocked by the ATM specific inhibitor KU55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	154-161	ATM serine/threonine kinase	Homo sapiens	131-134	
31299316-8	2019	ATM inhibitors, including KU-55933, KU-60019, KU-59403, CP-466722, AZ31, AZ32, AZD0156, and AZD1390, have been evaluated for their antitumor effects.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	26-34	ATM serine/threonine kinase	Homo sapiens	0-3	
31362335-6	2019	Interestingly, combined treatment with PF-477736 and the ATM inhibitor Ku55933 overcame the insensitivity of NB-39-nu and SK-N-BE cells to CHK1 inhibition and induced mitotic cell death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	71-78	ATM serine/threonine kinase	Homo sapiens	57-60	
29845714-12	2018	This route of cancer radioresistance can be overcome using the specific ATM kinase inhibitor, KU-55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	94-102	ATM serine/threonine kinase	Homo sapiens	72-75	
29186352-7	2018	Inhibitors of JAK2 (G6) and ATM (KU55933) abolished the PRL-mediated increase in cell viability of DNA-damaged cells, supporting the involvement of each, as well as the crosstalk of ATM with the PRL pathway in the context of DNA damage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-40	ATM serine/threonine kinase	Homo sapiens	28-31	
29235570-9	2018	These changes were at least partly ATM mediated, shown by reversal with the ATM inhibitor (KU55933).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	91-98	ATM serine/threonine kinase	Homo sapiens	35-38	
29235570-9	2018	These changes were at least partly ATM mediated, shown by reversal with the ATM inhibitor (KU55933).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	91-98	ATM serine/threonine kinase	Homo sapiens	76-79	
29396516-10	2018	Moreover, inhibition of RAP80 greatly sensitized EC cells to ATM inhibitor KU-55933, triggering a potential combination of RAP80 inhibitors and ATM inhibitors to enhance the therapeutic efficiency of ESCC patients for the clinicians.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	75-83	ATM serine/threonine kinase	Homo sapiens	61-64	
29396516-10	2018	Moreover, inhibition of RAP80 greatly sensitized EC cells to ATM inhibitor KU-55933, triggering a potential combination of RAP80 inhibitors and ATM inhibitors to enhance the therapeutic efficiency of ESCC patients for the clinicians.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	75-83	ATM serine/threonine kinase	Homo sapiens	144-147	
29186352-7	2018	Inhibitors of JAK2 (G6) and ATM (KU55933) abolished the PRL-mediated increase in cell viability of DNA-damaged cells, supporting the involvement of each, as well as the crosstalk of ATM with the PRL pathway in the context of DNA damage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-40	ATM serine/threonine kinase	Homo sapiens	182-185	
29111814-4	2017	The ATM kinase inhibitor, KU55933, could reverse SW-induced ERK phosphorylation but not the reduced glutathione/oxidized glutathione (GSH/GSSG) imbalance in AGS cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	26-33	ATM serine/threonine kinase	Homo sapiens	4-7	
29241579-7	2017	KU-55933, an inhibitor of ATM, inhibited the phosphorylation of ATM induced by PUN and reversed the decreased cell viability caused by PUN.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	26-29	
29241579-7	2017	KU-55933, an inhibitor of ATM, inhibited the phosphorylation of ATM induced by PUN and reversed the decreased cell viability caused by PUN.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	64-67	
28418119-9	2017	NF-kappaB activator TNF-alpha and the ATM inhibitor Ku55933 offset the regulatory effect of eIF2alpha on the expression of radiation-induced cell apoptosis-related proteins and the G2/M phase arrest-related proteins.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	52-59	ATM serine/threonine kinase	Homo sapiens	38-41	
28341201-2	2017	Thus, the neuroprotective efficacy of KU-55933, a potent inhibitor of ATM, against cell damage evoked by oxidative stress (hydrogen peroxide, H2O2) has been studied in human neuroblastoma SH-SY5Y cells and compared with the efficacy of this agent in models of doxorubicin (Dox)- and staurosporine (St)-evoked cell death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	38-46	ATM serine/threonine kinase	Homo sapiens	70-73	
27108928-6	2016	KU-55933, a selective ATM kinase inhibitor, partly rescued NIS expression and iodide transport in DNA-damaged cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	22-25	
28544661-9	2017	Through inhibition by KU55933, DDR pathway in early-passage MSCs was shown to be ATM-dependent.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	22-29	ATM serine/threonine kinase	Homo sapiens	81-84	
28387728-8	2017	However, pre-treatment of DU145 naive cells with an ATM (KU55933) inhibitor does not affect the BE elicited by MVs isolated from etoposide-treated cells, indicating that the BE is induced upstream of ATM actions.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	57-64	ATM serine/threonine kinase	Homo sapiens	52-55	
28182994-7	2017	Moreover, HCT116 cells are sensitive to olaparib in combination with the ATM inhibitor KU55933, and sensitivity is enhanced by deletion of p53.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	87-94	ATM serine/threonine kinase	Homo sapiens	73-76	
28202068-8	2017	The role of DDR in JCV infection was analyzed using a small molecule inhibitor of ATM (KU-55933).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	87-95	ATM serine/threonine kinase	Homo sapiens	82-85	
28638267-3	2017	KU-55933 is a specific ATM inhibitor, which has pro-apoptotic effect on tumor cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	23-26	
27829214-6	2016	Inhibition of PIKKs or ATM (with wortmannin and KU55933, respectively) prevented the agglomeration and degradation of PICT-1, suggesting that ATM is a key regulator of PICT-1.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	48-55	ATM serine/threonine kinase	Homo sapiens	23-26	
27829214-6	2016	Inhibition of PIKKs or ATM (with wortmannin and KU55933, respectively) prevented the agglomeration and degradation of PICT-1, suggesting that ATM is a key regulator of PICT-1.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	48-55	ATM serine/threonine kinase	Homo sapiens	142-145	
26442630-8	2016	In addition, the ATM-specific inhibitor KU-55933 reversed curcumin-induced phosphorylation of H2A.X.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	40-48	ATM serine/threonine kinase	Homo sapiens	17-20	
27087371-6	2016	KU-55933, an inhibitor of ATM, reversed the expression of relevant proteins and G(2)/M phase arrest induced by Jaridonin.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	26-29	
27551505-5	2016	Moreover, ATM/DNA-PKcs inhibitor KU55933, p53 inhibitor PFT-mu and pan-caspase inhibitor ZVAD-fmk significantly decreased X-irradiation-induced pan-nuclear gammaH2AX signals and TUNEL staining, protected HPBLs from apoptosis, but decreased the proliferative response to mitogen in X-irradiated HPBLs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-40	ATM serine/threonine kinase	Homo sapiens	10-13	
27551505-6	2016	Notably, whereas both KU55933 and PFT-mu increased the IR-induced chromosome breaks and mis-repair events through inhibiting the formation of p-ATM, p-DNA-PKcs and gammaH2AX foci in X-irradiated HPBLs, the ZVAD-fmk did not increase the IR-induced chromosomal instability.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	22-29	ATM serine/threonine kinase	Homo sapiens	144-147	
27047993-4	2016	Additional experiments were done in cells expressing shRNA against ATM or in the presence of the ATM inhibitor KU55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	111-118	ATM serine/threonine kinase	Homo sapiens	97-100	
26851027-5	2016	Blockade of ATM activation by specific inhibitor KU55933, short hairpin RNA, or kinase-dead ATM overexpression suppressed JNK phosphorylation but did not completely inhibit cytosolic ROS production, mitochondrial cytochrome c release, pro-caspase-3 cleavage, and apoptosis induced by GA. Taken together, these results indicate that GA induces OC cell apoptosis by inducing the activation of mitochondrial apoptotic and ATM-JNK signal pathways, likely through ER Ca(++)-mediated ROS production.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	49-56	ATM serine/threonine kinase	Homo sapiens	12-15	
27089984-4	2016	However, in GM05849 cells or GM00637 cells pretreated with the ATM kinase inhibitor KU55933, the expression of full-length PINK1 and the translocation of Parkin are blocked, and the colocalization of Parkin with either LC3 or PINK1 is disrupted.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	84-91	ATM serine/threonine kinase	Homo sapiens	63-66	
26636375-3	2016	In the present study by using the specific inhibitors Ku55933 and Pifithrin-alpha, we confirmed implication of both ATM and p53 in H(2)O(2)-induced senescence of hMESCs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	54-61	ATM serine/threonine kinase	Homo sapiens	116-119	
25801233-1	2015	The aim of the present study is to evaluate the role of ATM (KU55933) and DNA-PK (NU7441) inhibitors in the repair of double-strand breaks and downstream signaling of DNA damage introduced by ionizing radiation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	61-68	ATM serine/threonine kinase	Homo sapiens	56-59	
25598069-5	2015	Furthermore, the ATM-specific inhibitor KU-55933 blocked porcine oocyte maturation, reducing the percentages of oocytes that underwent germinal vesicle breakdown (GVBD) and first polar body extrusion.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	40-48	ATM serine/threonine kinase	Homo sapiens	17-20	
25205037-6	2015	Inhibition of ATM kinase by KU-55933 produced potent radiosensitisation of GBM CSCs (sensitiser enhancement ratios 2.6-3.5) and effectively abrogated the enhanced DSB repair proficiency observed in GBM CSCs at 24 h post irradiation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	28-36	ATM serine/threonine kinase	Homo sapiens	14-17	
25585815-0	2015	The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	ATM serine/threonine kinase	Homo sapiens	4-7	
25585815-9	2015	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (KU55933) significantly sensitized siDAB2IP cells to IR due to inhibition of the phosphorylation of ATM and its downstream targets following IR and slower DSB repair kinetics.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-46	ATM serine/threonine kinase	Homo sapiens	147-150	
25585815-9	2015	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (KU55933) significantly sensitized siDAB2IP cells to IR due to inhibition of the phosphorylation of ATM and its downstream targets following IR and slower DSB repair kinetics.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	48-55	ATM serine/threonine kinase	Homo sapiens	147-150	
25585815-11	2015	KU55933, which suppresses ATM phosphorylation upon irradiation, could be applied in the radiotherapy of BCa patients with a DAB2IP gene defect.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-7	ATM serine/threonine kinase	Homo sapiens	26-29	
25766900-7	2015	Furthermore, treatment with the autophagy inhibitor 3-MA or ATM inhibitor KU55933 resulted in enhanced ROS accumulation and attenuation of the effect of prolonged FDT-mediated protection on irradiated HEI-OC1 cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	74-81	ATM serine/threonine kinase	Homo sapiens	60-63	
25527123-10	2014	The S arrest and the activation of ATM-Chk1/Chk2-Cdc25A-Cdk2 pathways induced by SC-III3 in HepG2 cells could be efficiently abrogated by pretreatments of either Ku55933 (an inhibitor of ATM) or UCN-01 (an inhibitor of Chk1/Chk2).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	162-169	ATM serine/threonine kinase	Homo sapiens	35-38	
25527123-10	2014	The S arrest and the activation of ATM-Chk1/Chk2-Cdc25A-Cdk2 pathways induced by SC-III3 in HepG2 cells could be efficiently abrogated by pretreatments of either Ku55933 (an inhibitor of ATM) or UCN-01 (an inhibitor of Chk1/Chk2).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	162-169	ATM serine/threonine kinase	Homo sapiens	187-190	
24480460-5	2014	Treatment of cells overexpressing Aurora-A and ATM/Chk2 with the ATM specific inhibitor KU-55933 increased the cell sensitivity to cisplatin and irradiation through increasing the phosphorylation of p53 at Ser15 and inhibiting the expression of Chk2, gammaH2AX (Ser319), and RAD51.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	88-96	ATM serine/threonine kinase	Homo sapiens	47-50	
25486524-10	2014	Similarly, inhibition of ATM with KU55933 abrogated nuclear cyclin D1 accumulation by induction of apoptosis in ATM-complemented cells exposed to low-dose FR.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	34-41	ATM serine/threonine kinase	Homo sapiens	25-28	
25486524-10	2014	Similarly, inhibition of ATM with KU55933 abrogated nuclear cyclin D1 accumulation by induction of apoptosis in ATM-complemented cells exposed to low-dose FR.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	34-41	ATM serine/threonine kinase	Homo sapiens	112-115	
24821553-5	2014	We also found that the ATM protein kinase phosphorylated HNF1alpha at Ser249 in vitro in an ATM-dependent manner and that ATM inhibitor KU55933 treatment inhibited phosphorylation of HNF1alpha at Ser249 in vivo.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	136-143	ATM serine/threonine kinase	Homo sapiens	23-26	
24821553-5	2014	We also found that the ATM protein kinase phosphorylated HNF1alpha at Ser249 in vitro in an ATM-dependent manner and that ATM inhibitor KU55933 treatment inhibited phosphorylation of HNF1alpha at Ser249 in vivo.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	136-143	ATM serine/threonine kinase	Homo sapiens	92-95	
24821553-5	2014	We also found that the ATM protein kinase phosphorylated HNF1alpha at Ser249 in vitro in an ATM-dependent manner and that ATM inhibitor KU55933 treatment inhibited phosphorylation of HNF1alpha at Ser249 in vivo.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	136-143	ATM serine/threonine kinase	Homo sapiens	92-95	
24480460-5	2014	Treatment of cells overexpressing Aurora-A and ATM/Chk2 with the ATM specific inhibitor KU-55933 increased the cell sensitivity to cisplatin and irradiation through increasing the phosphorylation of p53 at Ser15 and inhibiting the expression of Chk2, gammaH2AX (Ser319), and RAD51.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	88-96	ATM serine/threonine kinase	Homo sapiens	65-68	
24966912-7	2014	The levels of intracellular reactive oxygen species (ROS) were significantly increased in HBX-expressing cells treated with hydrogen peroxide in the presence of ATM inhibitor KU55933 or caffeine.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	175-182	ATM serine/threonine kinase	Homo sapiens	161-164	
24622963-9	2014	This effect required functional ATM since cells treated simultaneously with Nu7441 and the ATM inhibitor Ku55933 were resistant to apoptosis despite high levels of residual foci.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	105-112	ATM serine/threonine kinase	Homo sapiens	32-35	
24622963-9	2014	This effect required functional ATM since cells treated simultaneously with Nu7441 and the ATM inhibitor Ku55933 were resistant to apoptosis despite high levels of residual foci.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	105-112	ATM serine/threonine kinase	Homo sapiens	91-94	
24841718-6	2014	Moreover, reducing ATM kinase activity using a small-molecule inhibitor (KU55933) or shRNA-mediated depletion of ATM protein enhanced olaparib sensitivity in gastric cancer cell lines with depletion or inactivation of p53.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	73-80	ATM serine/threonine kinase	Homo sapiens	19-22	
24568192-12	2014	The radiation-induced apoptosis was increased by inhibition of NF-kappaB using PDTC or inhibition of ATM using KU55933 or siRNA against ATM.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	111-118	ATM serine/threonine kinase	Homo sapiens	101-104	
24464432-4	2014	Previously identified small-molecule ATM kinase inhibitors, such as CP466722 and Ku55933, were identified using in vitro kinase assays carried out with recombinant ATM kinase isolated from mammalian cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	81-88	ATM serine/threonine kinase	Homo sapiens	37-40	
24464432-4	2014	Previously identified small-molecule ATM kinase inhibitors, such as CP466722 and Ku55933, were identified using in vitro kinase assays carried out with recombinant ATM kinase isolated from mammalian cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	81-88	ATM serine/threonine kinase	Homo sapiens	164-167	
24370835-11	2014	ATM inhibition by KU-55933 reduces epithelial infection and stromal disease severity without producing appreciable toxicity.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-26	ATM serine/threonine kinase	Homo sapiens	0-3	
23897750-7	2013	Treatment of BOEC from COPD patients with the SIRT1 activator resveratrol or an ATM inhibitor (KU-55933) also rescued the senescent phenotype.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	95-103	ATM serine/threonine kinase	Homo sapiens	80-83	
23460736-3	2013	Inhibition of ATM with the highly selective antagonist KU55933 markedly increased IL-23 secretion in human monocyte-derived DC and freshly isolated myeloid DC.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	55-62	ATM serine/threonine kinase	Homo sapiens	14-17	
23934411-8	2013	The inhibition of kinase ATR with its specific inhibitor VE-821 resulted in a more pronounced radiosensitizing effect in HL-60 cells as compared to the inhibition of kinase ATM with the inhibitor KU55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	196-203	ATM serine/threonine kinase	Homo sapiens	173-176	
23839822-6	2013	To confirm this hypothesis, we demonstrate that the ATM inhibitor KU55933 increased the oncolytic activity of dl922-947 and its replication.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	66-73	ATM serine/threonine kinase	Homo sapiens	52-55	
23460736-9	2013	Importantly, ATM inhibition with KU55933 prevented radiation-induced ATM phosphorylation and abrogated the capacity of x-rays to suppress IL-23.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-40	ATM serine/threonine kinase	Homo sapiens	13-16	
23460736-9	2013	Importantly, ATM inhibition with KU55933 prevented radiation-induced ATM phosphorylation and abrogated the capacity of x-rays to suppress IL-23.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-40	ATM serine/threonine kinase	Homo sapiens	69-72	
23058634-6	2012	Next, we used ATM inhibitor, KU 55933, which has been shown previously to be a radio/chemo-sensitizing agent.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	29-37	ATM serine/threonine kinase	Homo sapiens	14-17	
23054561-0	2012	ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	14-22	ATM serine/threonine kinase	Homo sapiens	0-3	
23178571-4	2013	Normal cells treated with combination of KU55933, a specific ATM kinase inhibitor, and doxorubicin showed increased resistance as they do in a similar manner to A-T cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	41-48	ATM serine/threonine kinase	Homo sapiens	61-64	
23117293-8	2013	However, this effect was blocked when NHL cells were pre-treated with 10 micromol/l of KU55933, a specific inhibitor of ataxia-telangiectasia-mutated (ATM).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	87-94	ATM serine/threonine kinase	Homo sapiens	120-149	
23117293-8	2013	However, this effect was blocked when NHL cells were pre-treated with 10 micromol/l of KU55933, a specific inhibitor of ataxia-telangiectasia-mutated (ATM).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	87-94	ATM serine/threonine kinase	Homo sapiens	151-154	
23015717-4	2012	Using an ATM inhibitor (KU55933), we found that ATM activity is required for efficient induction of EBV lytic gene expression by a variety of different stimuli, including a histone deacetylase (HDAC) inhibitor, the transforming growth factor beta (TGF-beta) cytokine, a demethylating agent (5-azacytidine), B cell receptor engagement with anti-IgG antibody, hydrogen peroxide, and the proteosome inhibitor bortezomib.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	24-31	ATM serine/threonine kinase	Homo sapiens	9-12	
23015717-4	2012	Using an ATM inhibitor (KU55933), we found that ATM activity is required for efficient induction of EBV lytic gene expression by a variety of different stimuli, including a histone deacetylase (HDAC) inhibitor, the transforming growth factor beta (TGF-beta) cytokine, a demethylating agent (5-azacytidine), B cell receptor engagement with anti-IgG antibody, hydrogen peroxide, and the proteosome inhibitor bortezomib.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	24-31	ATM serine/threonine kinase	Homo sapiens	48-51	
23058634-7	2012	Pretreatment of resting T cells with KU 55933 blocked phosphorylation of ATM, H2AX and p53, which, in turn, prevented PUMA expression, caspase activation and apoptosis.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	37-45	ATM serine/threonine kinase	Homo sapiens	73-76	
22390926-5	2012	Co-treatment with the ataxia-telangiectasia mutated (ATM) kinase inhibitor KU55933 desensitized the control shRNA cells, but not WRN shRNA cells, to MSeA treatment.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	75-82	ATM serine/threonine kinase	Homo sapiens	22-51	
22909323-3	2012	We combined SILAC-based tandem mass spectrometry and a subcellular fractionation protocol to interrogate the proteome of irradiated cells treated with or without the ATM kinase inhibitor KU55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	187-194	ATM serine/threonine kinase	Homo sapiens	166-169	
22923485-6	2012	ATM deficiency or ATM inhibition with KU55933 produced a similar effect.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	38-45	ATM serine/threonine kinase	Homo sapiens	18-21	
22290195-7	2012	An ATM inhibitor, Ku55933, reduced H(2) O(2) -induced apoptosis in LNCaP and 22Rv1 cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	ATM serine/threonine kinase	Homo sapiens	3-6	
22290195-9	2012	The ATM inhibitor Ku55933 inhibited androgen-induced phosphorylation of ATM and PARP cleavage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	ATM serine/threonine kinase	Homo sapiens	4-7	
22290195-9	2012	The ATM inhibitor Ku55933 inhibited androgen-induced phosphorylation of ATM and PARP cleavage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	ATM serine/threonine kinase	Homo sapiens	72-75	
22265862-3	2012	When hepatoma cell lines HepG2 and PLC/PRF/5 were treated with sorafenib plus ATM small inhibitory RNAs, ATM inhibitor KU55933 or caffeine, Akt signaling was suppressed and the cytotoxic effects were significantly potentiated.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	119-126	ATM serine/threonine kinase	Homo sapiens	105-108	
22728709-0	2012	Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	37-44	ATM serine/threonine kinase	Homo sapiens	30-33	
22728709-0	2012	Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	37-44	ATM serine/threonine kinase	Homo sapiens	56-59	
22763242-3	2012	MATERIALS AND METHODS: We use KU55933 to inhibit ATM kinase activity.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	30-37	ATM serine/threonine kinase	Homo sapiens	49-52	
22627294-7	2012	The phosphorylation of p53 was inhibited by KU-55933, an inhibitor of ataxia-telangiectasia mutated kinase (ATM), but not by NU7026, an inhibitor of DNA-dependent protein kinase (DNA-PK).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	44-52	ATM serine/threonine kinase	Homo sapiens	70-106	
22627294-7	2012	The phosphorylation of p53 was inhibited by KU-55933, an inhibitor of ataxia-telangiectasia mutated kinase (ATM), but not by NU7026, an inhibitor of DNA-dependent protein kinase (DNA-PK).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	44-52	ATM serine/threonine kinase	Homo sapiens	108-111	
22390926-5	2012	Co-treatment with the ataxia-telangiectasia mutated (ATM) kinase inhibitor KU55933 desensitized the control shRNA cells, but not WRN shRNA cells, to MSeA treatment.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	75-82	ATM serine/threonine kinase	Homo sapiens	53-56	
22226932-6	2012	ATM inhibitors, including Ku55933 and caffeine, and the genetic or pharmacological inhibition of p53 prevented capsaicin-induced DNA-PKcs phosphorylation and stimulated PARP-1 cleavage, but had no effect on microtubule-associated protein light chain 3 (LC3)-II levels.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	26-33	ATM serine/threonine kinase	Homo sapiens	0-3	
22525466-4	2012	Researchers recently developed three ATM inhibitors (KU-55933, CGK733, and CP466722) and an MRN complex inhibitor (mirin) and showed that they have great potential as radiosensitizers of tumors in preclinical studies.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	53-61	ATM serine/threonine kinase	Homo sapiens	37-40	
23185347-0	2012	Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	109-117	ATM serine/threonine kinase	Homo sapiens	95-98	
23185347-1	2012	KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with key roles in DNA repair.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	82-111	
23185347-1	2012	KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with key roles in DNA repair.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	0-8	ATM serine/threonine kinase	Homo sapiens	113-116	
21616090-6	2011	Pretreatment with the ATM inhibitor KU55933 enhanced 5-MF-induced gamma-H2AX formation and caspase-7 cleavage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	36-43	ATM serine/threonine kinase	Homo sapiens	22-25	
21973212-5	2011	Pretreatment with KU55933, an ATM kinase inhibitor, or NU7026, an inhibitor of DNA-dependent protein kinase, desensitizes MSeA cytotoxicity in scrambled but not p53 shRNA MRC-5 cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	ATM serine/threonine kinase	Homo sapiens	30-33	
21945951-6	2011	This activation was strongly attenuated by two inhibitors of the ATM kinase (caffeine and Ku-55933), which is dysfunctional in ataxia-telanagiectasia patients.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	90-98	ATM serine/threonine kinase	Homo sapiens	65-68	
21889946-6	2011	Normal lung fibroblast cells treated with KU-55933, a specific ATM kinase inhibitor, showed increased numbers of exchanges at a dose of 1Gy and higher, but were similar to wild type cells at 0.5Gy or below.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	42-50	ATM serine/threonine kinase	Homo sapiens	63-66	
21937706-7	2011	The cytoplasmic THOC5-dependent mRNAs were recovered by treatment with ATM kinase-specific or p53-specific siRNA, as well as by treatment with ATM kinase inhibitor, KU55933, under DNA damage conditions, suggesting that the ATM-kinase-p53 pathway is involved in this response to the DNA damage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	165-172	ATM serine/threonine kinase	Homo sapiens	143-146	
21937706-7	2011	The cytoplasmic THOC5-dependent mRNAs were recovered by treatment with ATM kinase-specific or p53-specific siRNA, as well as by treatment with ATM kinase inhibitor, KU55933, under DNA damage conditions, suggesting that the ATM-kinase-p53 pathway is involved in this response to the DNA damage.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	165-172	ATM serine/threonine kinase	Homo sapiens	143-146	
21937706-8	2011	Furthermore, the treatment with KU55933 blocked DNA damage-induced THOC5mRNP complex dissociation, indicating that activation of ATM kinase suppresses the ability of THOC5 to bind to its target mRNAs.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	32-39	ATM serine/threonine kinase	Homo sapiens	129-132	
21532626-9	2011	Using the specific ATM inhibitor KU-55933 we confirm the essential role of ATM in the induction of p21 for G2 arrest of normal cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-41	ATM serine/threonine kinase	Homo sapiens	19-22	
21532626-9	2011	Using the specific ATM inhibitor KU-55933 we confirm the essential role of ATM in the induction of p21 for G2 arrest of normal cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	33-41	ATM serine/threonine kinase	Homo sapiens	75-78	
21424556-8	2011	However, pharmacological inhibition of ATM using KU55933 and caffeine suggests that ATM inhibition by ROSC is not the only mechanism that might explain the anti-apoptotic effects of this drug in this apoptosis model.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	49-56	ATM serine/threonine kinase	Homo sapiens	39-42	
20978197-8	2010	Caffeine and the ATM inhibitor Ku55933 cause polbeta-Delta-dependent radiosensitization.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	31-38	ATM serine/threonine kinase	Homo sapiens	17-20	
21325885-5	2011	Activation of ATM and CHEK2 occurred at the same time as this early arrest and was, like the arrest, abrogated by the ATM-inhibitor KU-55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	132-140	ATM serine/threonine kinase	Homo sapiens	14-17	
21325885-5	2011	Activation of ATM and CHEK2 occurred at the same time as this early arrest and was, like the arrest, abrogated by the ATM-inhibitor KU-55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	132-140	ATM serine/threonine kinase	Homo sapiens	118-121	
21195095-7	2011	Moreover, the cadmium-induced RAR was totally suppressed by KU-55933, a specific ATM inhibitor that did not change the CSE expression after radiation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	60-68	ATM serine/threonine kinase	Homo sapiens	81-84	
20502937-2	2010	In CGC, the selective ATM inhibitor KU-55933 showed neuroprotective effects against MPP(+)-induced neuronal cell loss and apoptosis, lending support to the key role of ATM in experimental models of Parkinson"s disease.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	36-44	ATM serine/threonine kinase	Homo sapiens	22-25	
20502937-2	2010	In CGC, the selective ATM inhibitor KU-55933 showed neuroprotective effects against MPP(+)-induced neuronal cell loss and apoptosis, lending support to the key role of ATM in experimental models of Parkinson"s disease.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	36-44	ATM serine/threonine kinase	Homo sapiens	168-171	
20053781-0	2010	The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-26	ATM serine/threonine kinase	Homo sapiens	4-7	
20615625-8	2010	The ATM inhibitor KU-55933 blocked IR activation of AMPK.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-26	ATM serine/threonine kinase	Homo sapiens	4-7	
20053781-4	2010	Our study shows that a specific ATM inhibitor, KU-55933, blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	47-55	ATM serine/threonine kinase	Homo sapiens	32-35	
19996277-7	2009	The pretreatment with ATM inhibitor ku55933 and ATM siRNA effectively reduced the production of gamma-H2AX and LC3-II.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	36-43	ATM serine/threonine kinase	Homo sapiens	22-25	
19530246-5	2009	HKH40A also activated the c-Jun N-terminal kinase (JNK) pathway, most likely regulated by ATM kinase, since pre-treatment of Hep3B cells with ATM inhibitor KU-55933 or ATM siRNA transfection antagonized HKH40A-induced c-Jun phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	156-164	ATM serine/threonine kinase	Homo sapiens	90-93	
19583974-5	2009	We show here that KU55933, an ATM inhibitor could distinctly lower the clonogenic survival in normal human skin fibroblast cells exposed to carbon ion radiation and dramatically impair the normal process for DSB repair.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	ATM serine/threonine kinase	Homo sapiens	30-33	
19903334-3	2009	Caffeine as well as more specific inhibitors of ATM (KU55933) or ATM and ATR (CGK733) have recently been shown to induce cell death in drug-induced senescent tumor cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	53-60	ATM serine/threonine kinase	Homo sapiens	48-51	
19530246-5	2009	HKH40A also activated the c-Jun N-terminal kinase (JNK) pathway, most likely regulated by ATM kinase, since pre-treatment of Hep3B cells with ATM inhibitor KU-55933 or ATM siRNA transfection antagonized HKH40A-induced c-Jun phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	156-164	ATM serine/threonine kinase	Homo sapiens	142-145	
19530246-5	2009	HKH40A also activated the c-Jun N-terminal kinase (JNK) pathway, most likely regulated by ATM kinase, since pre-treatment of Hep3B cells with ATM inhibitor KU-55933 or ATM siRNA transfection antagonized HKH40A-induced c-Jun phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	156-164	ATM serine/threonine kinase	Homo sapiens	142-145	
19808981-3	2009	Recently, a specific inhibitor of the ATM kinase, KU-55933, was shown to radiosensitize human cancer cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	50-58	ATM serine/threonine kinase	Homo sapiens	38-41	
19465392-5	2009	In the presence of FdU and KU55933, an ATM inhibitor, the incidence of chromosome fragility is reduced, suggesting that ATM contributes to FdU-induced chromosome fragility.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	27-34	ATM serine/threonine kinase	Homo sapiens	39-42	
19695441-5	2009	Pretreatment of specific ATM inhibitor (10 microM KU55933) and activator (20 microg/mL chloroquine) before carbon radiation were adopted to explore the involvement of ATM.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	50-57	ATM serine/threonine kinase	Homo sapiens	25-28	
19502594-6	2009	Moreover, we observed that CPS activates ATM kinase that is involved in Ser15, Ser20 and Ser392 p53 phosphorylation as shown by the use of the specific inhibitor KU55933.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	162-169	ATM serine/threonine kinase	Homo sapiens	41-44	
19544417-8	2009	Finally, we demonstrate an essential role of ATM in establishing G(2) arrest since inhibition with the ATM-specific inhibitor KU55933 resulted in abolishment of G(2) arrest, evidenced by an increase in the number of cycling cells 2 hours after irradiation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	126-133	ATM serine/threonine kinase	Homo sapiens	45-48	
19544417-8	2009	Finally, we demonstrate an essential role of ATM in establishing G(2) arrest since inhibition with the ATM-specific inhibitor KU55933 resulted in abolishment of G(2) arrest, evidenced by an increase in the number of cycling cells 2 hours after irradiation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	126-133	ATM serine/threonine kinase	Homo sapiens	103-106	
19465392-5	2009	In the presence of FdU and KU55933, an ATM inhibitor, the incidence of chromosome fragility is reduced, suggesting that ATM contributes to FdU-induced chromosome fragility.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	27-34	ATM serine/threonine kinase	Homo sapiens	120-123	
16983346-6	2007	An increase of the HR rate enhanced by Vpr was attenuated by an ATM inhibitor, KU55933, suggesting that Vpr-induced DSBs activate ATM-dependent cellular signal that enhances the intracellular recombination potential.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	79-86	ATM serine/threonine kinase	Homo sapiens	64-67	
18347191-8	2008	We found that blocking ATM/ATR signaling with pharmacologic inhibitors, including the novel ATM inhibitors KU55933 and CGK733, induced senescent breast, lung, and colon carcinoma cells to undergo cell death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	107-114	ATM serine/threonine kinase	Homo sapiens	23-26	
18347191-8	2008	We found that blocking ATM/ATR signaling with pharmacologic inhibitors, including the novel ATM inhibitors KU55933 and CGK733, induced senescent breast, lung, and colon carcinoma cells to undergo cell death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	107-114	ATM serine/threonine kinase	Homo sapiens	92-95	
18248856-11	2008	Furthermore, persistent inhibition of foci growth of phosphorylated ATM by an ATM inhibitor, KU55933, completely abrogated p53 phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	93-100	ATM serine/threonine kinase	Homo sapiens	68-71	
18248856-11	2008	Furthermore, persistent inhibition of foci growth of phosphorylated ATM by an ATM inhibitor, KU55933, completely abrogated p53 phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	93-100	ATM serine/threonine kinase	Homo sapiens	78-81	
17371003-5	2007	Extended libraries exploring the 6-position of 2-morpholino-pyran-4-ones and 2-morpholino-thiopyrano-4-ones identified the first highly potent and selective ATM inhibitor 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (151C; ATM; IC50=13 nM) and revealed constrained SARs for ATM inhibition compared with DNA-PK.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	171-217	ATM serine/threonine kinase	Homo sapiens	157-160	
17371003-5	2007	Extended libraries exploring the 6-position of 2-morpholino-pyran-4-ones and 2-morpholino-thiopyrano-4-ones identified the first highly potent and selective ATM inhibitor 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (151C; ATM; IC50=13 nM) and revealed constrained SARs for ATM inhibition compared with DNA-PK.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	171-217	ATM serine/threonine kinase	Homo sapiens	225-228	
17371003-5	2007	Extended libraries exploring the 6-position of 2-morpholino-pyran-4-ones and 2-morpholino-thiopyrano-4-ones identified the first highly potent and selective ATM inhibitor 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (151C; ATM; IC50=13 nM) and revealed constrained SARs for ATM inhibition compared with DNA-PK.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	171-217	ATM serine/threonine kinase	Homo sapiens	225-228	
19351839-4	2009	Pretreatment of several melanoma lines just before gamma-irradiation with the inhibitor of ATM kinase KU-55933 suppressed p53 and nuclear factor-kappaB (NF-kappaB) activation but notably increased radiation-induced DR5 surface expression, down-regulated cFLIP (caspase-8 inhibitor) levels, and substantially enhanced exogenous TRAIL-induced apoptosis.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	102-110	ATM serine/threonine kinase	Homo sapiens	91-94	
18596239-6	2008	Treatment of cells under replication stress with the ATM kinase inhibitor KU 55933 results in a S-phase checkpoint defect similar to that observed in WRN shRNA cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	74-82	ATM serine/threonine kinase	Homo sapiens	53-56	
17283137-5	2007	The ATM-specific inhibitor KU-55933 compromised HRR up to 90% in growth-arrested cells, whereas this effect was less pronounced in cycling cells.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	27-35	ATM serine/threonine kinase	Homo sapiens	4-7	
16983346-6	2007	An increase of the HR rate enhanced by Vpr was attenuated by an ATM inhibitor, KU55933, suggesting that Vpr-induced DSBs activate ATM-dependent cellular signal that enhances the intracellular recombination potential.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	79-86	ATM serine/threonine kinase	Homo sapiens	130-133	
16556909-2	2006	Here, we demonstrate that PARP-1-/- cells are sensitive to the ATM inhibitor KU55933 and conversely that AT cells are sensitive to the PARP inhibitor 4-amino-1,8-napthalamide.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	77-84	ATM serine/threonine kinase	Homo sapiens	63-66	
15604286-11	2004	We conclude that KU-55933 is a novel, specific, and potent inhibitor of the ATM kinase.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	17-25	ATM serine/threonine kinase	Homo sapiens	76-79	
34556870-4	2021	We determined the structure of the kinase domain bound to ATPgammaS and to the ATM inhibitors KU-55933 and M4076 at 2.8 A, 2.8 A and 3.0 A resolution, respectively.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	94-102	ATM serine/threonine kinase	Homo sapiens	79-82	
34784199-9	2021	Phosphoinositide-3-kinase (PI3K)/Akt inhibitors, LY294002, wortmannin, and GSK690693, also suppressed both Ac-H3 and gamma-H2AX, whereas KU-55933, an inhibitor of ataxia telangiectasia mutated (ATM) upstream of gamma-H2AX, inhibited gamma-H2AX but not Ac-H3.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	137-145	ATM serine/threonine kinase	Homo sapiens	194-197