PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20213763-3	2010	For this purpose, ATM activity was either inhibited pharmacologically with the specific inhibitor KU-55933, or the ATM gene was partially silenced by transfection with small interfering RNA (siRNA).	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	98-106	ATM serine/threonine kinase	Rattus norvegicus	18-21	
28257891-9	2017	Furthermore, intracerebroventricular injection of ataxia telangiectasia mutated (ATM) kinase inhibitor (KU-55933) significantly reduced HSP27 phosphorylation and G6PD upregulation after MCAO, but that of protein kinase D inhibitor (CID755673) did not affect HSP27 phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	104-112	ATM serine/threonine kinase	Rattus norvegicus	81-84	
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	193-200	ATM serine/threonine kinase	Rattus norvegicus	73-102	
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	193-200	ATM serine/threonine kinase	Rattus norvegicus	104-107	
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	193-200	ATM serine/threonine kinase	Rattus norvegicus	133-136	
21729327-6	2011	In addition, we found that ATBF1-mediated neuronal death is dependent on ataxia-telangiectasia mutated (ATM) because the blockage of ATM activity by treatment with ATM inhibitors, caffeine and KU55933, abolished ATBF1 function in neuronal death.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	193-200	ATM serine/threonine kinase	Rattus norvegicus	133-136	
29510140-12	2018	Intracerebroventricular injection of ATM kinase inhibitor (KU-55933) significantly reduced HSP27 phosphorylation and G6PD activity, significantly increased protein carbonyl, and resulted in increase in infarct size (100%) 24-h after reperfusion following 90-min MCAO.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	59-67	ATM serine/threonine kinase	Rattus norvegicus	37-40	
28220272-8	2017	Furthermore, pharmacological inhibition of ATM kinase (KU55933) reduced activation of ATM kinase, but not p53, suggesting that HG-mediated activation of p53 and ATM could represent independent pro-apoptotic events.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	55-62	ATM serine/threonine kinase	Rattus norvegicus	43-46	
28220272-8	2017	Furthermore, pharmacological inhibition of ATM kinase (KU55933) reduced activation of ATM kinase, but not p53, suggesting that HG-mediated activation of p53 and ATM could represent independent pro-apoptotic events.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	55-62	ATM serine/threonine kinase	Rattus norvegicus	86-89	
28220272-8	2017	Furthermore, pharmacological inhibition of ATM kinase (KU55933) reduced activation of ATM kinase, but not p53, suggesting that HG-mediated activation of p53 and ATM could represent independent pro-apoptotic events.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	55-62	ATM serine/threonine kinase	Rattus norvegicus	86-89	
34388663-7	2021	We also observed downregulation of ATM and its phosphorylation after nerolidol treatment; furthermore, treatment with KU-55933, an ATM kinase inhibitor, mimicked the inhibitory effects of nerolidol treatment on cell proliferation and Akt phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	118-126	ATM serine/threonine kinase	Rattus norvegicus	35-38	
34388663-7	2021	We also observed downregulation of ATM and its phosphorylation after nerolidol treatment; furthermore, treatment with KU-55933, an ATM kinase inhibitor, mimicked the inhibitory effects of nerolidol treatment on cell proliferation and Akt phosphorylation.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	118-126	ATM serine/threonine kinase	Rattus norvegicus	131-134