PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16983346-6 2007 An increase of the HR rate enhanced by Vpr was attenuated by an ATM inhibitor, KU55933, suggesting that Vpr-induced DSBs activate ATM-dependent cellular signal that enhances the intracellular recombination potential. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 79-86 Vpr Human immunodeficiency virus 1 39-42 16983346-6 2007 An increase of the HR rate enhanced by Vpr was attenuated by an ATM inhibitor, KU55933, suggesting that Vpr-induced DSBs activate ATM-dependent cellular signal that enhances the intracellular recombination potential. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 79-86 Vpr Human immunodeficiency virus 1 104-107 16983346-7 2007 In context with a recent report that KU55933 attenuated the integration of HIV-1 into host genomes, we discuss the possible role of Vpr-induced DSBs in viral integration and also in HIV-1 associated malignancy. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 37-44 Vpr Human immunodeficiency virus 1 132-135