PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30539420-8 2019 The enhanced BCL2 and VEGF parallel with the reduced NFkappaB1, TNF-alpha, IL-1beta, and iNOS mRNA levels in miR-9 mimic or glucosamine-treated cells further substantiated their post-ischemic neuroprotective and regenerative efficacy. Glucosamine 124-135 tumor necrosis factor Homo sapiens 64-73 30713180-1 2018 AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2. Glucosamine 33-44 tumor necrosis factor Homo sapiens 228-237 27989826-8 2016 It was found that the formulation containing PLGA and glucosamine showed significantly higher reduction in both, knee diameter and TNF-alpha levels, compared to other groups. Glucosamine 54-65 tumor necrosis factor Homo sapiens 131-140 27927986-4 2017 Moreover, GlcN suppressed LPS-induced up-regulation of COX-2, IL-6, and TNF-alpha mRNAs under 25 mm glucose conditions yet did not inhibit up-regulation under 5 mm glucose conditions. Glucosamine 10-14 tumor necrosis factor Homo sapiens 72-81 22777418-2 2012 We hypothesized that d-glucosamine (d-GlcN) and Thiamet-G, two agents that increase protein O-GlcNAcylation via different mechanisms, inhibit TNF-alpha-induced oxidative stress and vascular dysfunction by suppressing inducible nitric oxide (NO) synthase (iNOS) expression. Glucosamine 21-34 tumor necrosis factor Homo sapiens 142-151 27776166-7 2016 Furthermore, GlcN suppressed the expression of proinflammatory cytokine genes (such as IL-6, IL-8, IL-24 and TNF-alpha genes). Glucosamine 13-17 tumor necrosis factor Homo sapiens 109-118 27776166-8 2016 In addition, GlcN-mediated O-GlcNAc modification was involved in the downregulation of TNF-alpha and IL-8 genes but not IL-6 and IL-24 genes, based on the effects of alloxan, an O-GlcNAc transferase inhibitor. Glucosamine 13-17 tumor necrosis factor Homo sapiens 87-96 22777418-2 2012 We hypothesized that d-glucosamine (d-GlcN) and Thiamet-G, two agents that increase protein O-GlcNAcylation via different mechanisms, inhibit TNF-alpha-induced oxidative stress and vascular dysfunction by suppressing inducible nitric oxide (NO) synthase (iNOS) expression. Glucosamine 36-42 tumor necrosis factor Homo sapiens 142-151 22777418-5 2012 d-GlcN and Thiamet-G pretreatment suppressed the TNF-alpha-induced hypocontractility and endothelial dysfunction. Glucosamine 0-6 tumor necrosis factor Homo sapiens 49-58 22777418-7 2012 Expression of iNOS protein was increased in TNF-alpha-treated rings, and this was attenuated by pretreatment with either d-GlcN or Thiamet-G. Glucosamine 121-127 tumor necrosis factor Homo sapiens 44-53 20113495-4 2010 METHODS: The human chondrosarcoma cell line HTB-94 and human primary chondrocytes were stimulated with tumor necrosis factor (TNF)alpha after pre-treatment with GlcN or NAPA. Glucosamine 161-165 tumor necrosis factor Homo sapiens 103-124 22427561-0 2012 Glucosamine modulates TNF-alpha-induced ICAM-1 expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells. Glucosamine 0-11 tumor necrosis factor Homo sapiens 22-31 22427561-1 2012 PURPOSE: The purpose of this article was to investigate the effects of glucosamine (GlcN) on the TNF-alpha-induced expression of intercellular adhesion molecule 1 (ICAM-1) and the function of ICAM-1 in ARPE-19 cells in vitro. Glucosamine 71-82 tumor necrosis factor Homo sapiens 97-106 22427561-1 2012 PURPOSE: The purpose of this article was to investigate the effects of glucosamine (GlcN) on the TNF-alpha-induced expression of intercellular adhesion molecule 1 (ICAM-1) and the function of ICAM-1 in ARPE-19 cells in vitro. Glucosamine 84-88 tumor necrosis factor Homo sapiens 97-106 22427561-9 2012 GlcN and tunicamycin reduced the molecular mass of TNF-alpha-induced ICAM-1 in ARPE-19 cells. Glucosamine 0-4 tumor necrosis factor Homo sapiens 51-60 22427561-10 2012 The proteasome inhibitor MG-132 suppressed the GlcN-induced reduction in the molecular mass of TNF-alpha-induced ICAM-1. Glucosamine 47-51 tumor necrosis factor Homo sapiens 95-104 22427561-11 2012 GlcN also attenuated the adhesion activity of TNF-alpha-induced ICAM-1. Glucosamine 0-4 tumor necrosis factor Homo sapiens 46-55 22427561-12 2012 CONCLUSIONS: GlcN inhibits ICAM-1 expression and functions by modulating the O-linked glycosylation of factors involved in NF-kappaB signaling and by reducing the N-linked glycosylation of TNF-alpha-induced ICAM-1 in ARPE-19 cells. Glucosamine 13-17 tumor necrosis factor Homo sapiens 189-198 22187328-13 2012 Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta. Glucosamine 93-104 tumor necrosis factor Homo sapiens 135-144 22966296-0 2010 Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine 57-68 tumor necrosis factor Homo sapiens 31-40 22966296-0 2010 Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine 158-169 tumor necrosis factor Homo sapiens 31-40 22966296-2 2010 However, it is unknown whether glucosamine reduces the expression of TNF-alpha-induced inflammatory cytokines in HaCaT cells. Glucosamine 31-42 tumor necrosis factor Homo sapiens 69-78 22966296-5 2010 Our data showed that the expression of IL-6, IL-8, TNF-alpha and IL-1beta was decreased by glucosamine treatment in the HaCaT cells. Glucosamine 91-102 tumor necrosis factor Homo sapiens 51-60 22966296-9 2010 Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta expression in the HaCaT cells. Glucosamine 24-35 tumor necrosis factor Homo sapiens 79-88 22966296-10 2010 However, the stimulation of TNF-alpha abolished the inhibitory effects of glucosamine on the expression of inflammatory cytokines in the HaCaT cells. Glucosamine 74-85 tumor necrosis factor Homo sapiens 28-37 22966296-11 2010 Thus, even though glucosamine induces the down-regulation of inflammatory cytokines in HaCaT cells, the anti-inflammatory role of glucosamine in TNF-alpha-mediated inflammatory skin diseases should be investigated. Glucosamine 130-141 tumor necrosis factor Homo sapiens 145-154 20113495-4 2010 METHODS: The human chondrosarcoma cell line HTB-94 and human primary chondrocytes were stimulated with tumor necrosis factor (TNF)alpha after pre-treatment with GlcN or NAPA. Glucosamine 161-165 tumor necrosis factor Homo sapiens 126-135 20113495-8 2010 RESULTS: After TNFalpha stimulation, the mRNA expression level of some of the genes under NF-kappaB control, such as interleukin (IL)-6 and IL-8, increased, while treatment with GlcN and NAPA reverted the effect. Glucosamine 178-182 tumor necrosis factor Homo sapiens 15-23 20110869-9 2009 The inhibition of MMP3 secretion due to GS plus CS was accompanied by a decrease in TNF-alpha production. Glucosamine 40-42 tumor necrosis factor Homo sapiens 84-93 19020780-2 2008 Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Glucosamine 36-47 tumor necrosis factor Homo sapiens 80-89 19020780-6 2008 The results demonstrated that glucosamine but not N-acetylglucosamine suppressed TNF-alpha-induced expression of MCP-1 and ICAM-1 at both the mRNA and protein levels. Glucosamine 30-41 tumor necrosis factor Homo sapiens 81-90 17238806-7 2006 Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta. Glucosamine 0-19 tumor necrosis factor Homo sapiens 82-91 18173918-0 2007 Glucosamine and its N-acetyl-phenylalanine derivative prevent TNF-alpha-induced transcriptional activation in human chondrocytes. Glucosamine 0-11 tumor necrosis factor Homo sapiens 62-71 18173918-2 2007 We analyzed the influence of GlcN and its N-acetyl-phenylalanine derivative (NAPA) on mRNA transcription level of TNF-alpha-stimulated genes in cell culture. Glucosamine 29-33 tumor necrosis factor Homo sapiens 114-123 19020780-0 2008 Modulation of TNF-alpha-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide. Glucosamine 63-74 tumor necrosis factor Homo sapiens 14-23 19020780-2 2008 Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Glucosamine 36-47 tumor necrosis factor Homo sapiens 51-78 18636175-0 2008 Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-alpha-stimulated human colonic epithelial HT-29 cells. Glucosamine 0-11 tumor necrosis factor Homo sapiens 73-82 18636175-4 2008 The results revealed that glucosamine suppressed the IL-8 production and ICAM-1 expression by TNF-alpha-activated HT-29 cells. Glucosamine 26-37 tumor necrosis factor Homo sapiens 94-103 18636175-5 2008 Furthermore, glucosamine inhibited the TNF-alpha-induced phosphorylation of p38MAPK and NF-kappaB p65, and the nuclear translocation of NF-kappaB in the cells. Glucosamine 13-24 tumor necrosis factor Homo sapiens 39-48 18173918-5 2007 RESULTS: Several genes, whose mRNA level was increased by TNF-alpha treatment and significantly reduced by GlcN and NAPA in lbpva55 cells, were identified. Glucosamine 107-111 tumor necrosis factor Homo sapiens 58-67 16822504-3 2006 We used flow cytometry and an ARPE-19 cell model to determine the effect of GS on the production of ICAM-1 in response to IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha plus IL-1beta, TNF-alpha plus IL-6, and TNF-alpha plus interferon (IFN)-gamma. Glucosamine 76-78 tumor necrosis factor Homo sapiens 138-171 17238806-7 2006 Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta. Glucosamine 0-19 tumor necrosis factor Homo sapiens 114-123 17238806-7 2006 Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta. Glucosamine 0-19 tumor necrosis factor Homo sapiens 114-123 17238806-9 2006 Glucosamine sulfate further inhibited the nuclear translocation of p65 protein in TNF-alpha- and IL-1beta-stimulated Chang conjunctival cells and phosphorylated STAT1 in IFN-gamma-stimulated Chang conjunctival cells. Glucosamine 0-19 tumor necrosis factor Homo sapiens 82-91 17238806-10 2006 Glucosamine sulfate also significantly reduced the number of neutrophils adhering to a conjunctival monolayer in response to TNF-alpha, IFN-gamma, or IL-1beta. Glucosamine 0-19 tumor necrosis factor Homo sapiens 125-134 16431966-0 2006 Glucosamine sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro. Glucosamine 0-19 tumor necrosis factor Homo sapiens 29-38 11290798-4 2001 It is shown that both glucosamine and N-acetylglucosamine inhibit IL-1beta- and TNF-alpha-induced NO production in normal human articular chondrocytes. Glucosamine 22-33 tumor necrosis factor Homo sapiens 80-89 8663078-0 1996 Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-alpha gene transcription. Glucosamine 22-33 tumor necrosis factor Homo sapiens 74-106 8663078-1 1996 Transforming growth factor-alpha (TGFalpha) gene transcription can be increased when arterial smooth muscle cells are exposed to supraphysiological concentrations of glucose, and this effect of glucose can be mimicked by glucosamine. Glucosamine 221-232 tumor necrosis factor Homo sapiens 0-32 15258595-3 2004 Dendrimer glucosamine inhibited Toll-like receptor 4-mediated lipopolysaccharide induced synthesis of pro-inflammatory chemokines (MIP-1 alpha, MIP-1 beta, IL-8) and cytokines (TNF-alpha, IL-1 beta, IL-6) from human dendritic cells and macrophages but allowed upregulation of the costimulatory molecules CD25, CD80, CD83 and CD86. Glucosamine 10-21 tumor necrosis factor Homo sapiens 177-186 14507305-6 2003 In cellular bioassays, GlcN was shown to inhibit the stimulatory activity of IL-4 and IL-2, as well as the cytotoxic activity of tumour necrosis factor-alpha (TNF-alpha). Glucosamine 23-27 tumor necrosis factor Homo sapiens 159-168 34867400-6 2021 Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels. Glucosamine 102-113 tumor necrosis factor Homo sapiens 201-209