PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25975052-8	2015	Levels of IL-1beta in joint fluid and MMP-1 in sera from the BHF- and GS-treated groups were significantly reduced.	Glucosamine	70-72	interleukin 1 beta	Rattus norvegicus	10-18	
11229466-0	2001	Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes.	Glucosamine	144-155	interleukin 1 beta	Rattus norvegicus	0-17	
11229466-0	2001	Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes.	Glucosamine	144-155	interleukin 1 beta	Rattus norvegicus	159-176	
11229466-1	2001	OBJECTIVE: To assess the variations of galactose-beta-1,3-glucuronosyltransferase I (GlcAT-I) expression related to the decrease in proteoglycan synthesis mediated by interleukin-1beta (IL-1beta) in rat chondrocytes, and to evaluate the influence of glucosamine on the effects elicited by this proinflammatory cytokine.	Glucosamine	250-261	interleukin 1 beta	Rattus norvegicus	167-184	
11229466-8	2001	In addition, glucosamine was able to prevent, in a dose-dependent manner, the inhibitory effects of IL-1beta.	Glucosamine	13-24	interleukin 1 beta	Rattus norvegicus	100-108	
11229466-10	2001	Finally, the up-regulation of stromelysin 1 (MMP-3) mRNA expression by IL-1beta was fully prevented by glucosamine.	Glucosamine	103-114	interleukin 1 beta	Rattus norvegicus	71-79	
11229466-12	2001	Glucosamine was highly effective in preventing these IL-1beta-mediated suppressive effects.	Glucosamine	0-11	interleukin 1 beta	Rattus norvegicus	53-61	
27044820-7	2016	RESULTS: CS-GlcN protected against cartilage degradation and reduced the levels of inflammatory mediators such as interleukin-1beta and tumor necrosis factor-alpha in the affected knee.	Glucosamine	12-16	interleukin 1 beta	Rattus norvegicus	114-163	
11801247-1	2002	We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and in UDP-glucuronosyltransferase I mRNA expression induced by interleukin-1 beta (IL-1 beta) [Arthritis Rheum.	Glucosamine	26-37	interleukin 1 beta	Rattus norvegicus	150-168	
25087910-2	2014	We sought to explore whether glucosamine can activate autophagy in rat nucleus pulposus (NP) cells and protect cells treated with IL-1beta or hydrogen peroxide (H2 O2 ).	Glucosamine	29-40	interleukin 1 beta	Rattus norvegicus	130-138	
25087910-9	2014	Autophagy in IL-1beta or H2 O2 -treated cells was increased by glucosamine.	Glucosamine	63-74	interleukin 1 beta	Rattus norvegicus	13-21	
25087910-10	2014	Glucosamine attenuated the decrease of aggrecan and prevented the apoptosis of the NP cells induced by IL-1beta, whereas 3-MA partly reversed these effects.	Glucosamine	0-11	interleukin 1 beta	Rattus norvegicus	103-111	
17109745-0	2006	Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta.	Glucosamine	10-21	interleukin 1 beta	Rattus norvegicus	87-95	
17109745-6	2006	Of the 2,813 genes whose transcription was altered by IL-1beta stimulation (P < 0.0001), glucosamine significantly blocked the response in 2,055 (approximately 73%).	Glucosamine	92-103	interleukin 1 beta	Rattus norvegicus	54-62	
17109745-10	2006	They suggest, however, that the potential benefit of glucosamine in osteoarthritis is not related to cartilage matrix biosynthesis, but is more probably related to its ability to globally inhibit the deleterious effects of IL-1beta signaling.	Glucosamine	53-64	interleukin 1 beta	Rattus norvegicus	223-231	
11801247-1	2002	We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and in UDP-glucuronosyltransferase I mRNA expression induced by interleukin-1 beta (IL-1 beta) [Arthritis Rheum.	Glucosamine	26-37	interleukin 1 beta	Rattus norvegicus	170-179	
11801247-4	2002	In order to better understand its mechanism of action, we determined if glucosamine could prevent the binding of IL-1 beta to its cellular receptors or could interfere with its signaling pathway at a post-receptor level.	Glucosamine	72-83	interleukin 1 beta	Rattus norvegicus	113-122	
11801247-5	2002	Addition of glucosamine to rat chondrocytes treated with IL-1 beta or with ROS decreased the activation of the nuclear factor kappa B, but not the activator protein-1.	Glucosamine	12-23	interleukin 1 beta	Rattus norvegicus	57-66	
11801247-6	2002	After treatment with IL-1 beta, glucosamine increased the expression of mRNA encoding the type II IL-1 beta receptor.	Glucosamine	32-43	interleukin 1 beta	Rattus norvegicus	21-30	
11801247-6	2002	After treatment with IL-1 beta, glucosamine increased the expression of mRNA encoding the type II IL-1 beta receptor.	Glucosamine	32-43	interleukin 1 beta	Rattus norvegicus	98-107	
11801247-7	2002	These results emphasize the potential role of two regulating proteins of the IL-1 beta signaling pathway that could account for the beneficial effect of glucosamine in osteoarthritis.	Glucosamine	153-164	interleukin 1 beta	Rattus norvegicus	77-86