PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25516476-11 2015 GlcN inhibited the insulin response under low (5 mM) glucose conditions, whereas it restored the insulin response for Akt phosphorylation under high (25 mM) glucose conditions in HepG2 and 3T3-L1 cells. Glucosamine 0-4 AKT serine/threonine kinase 1 Homo sapiens 118-121 26852666-6 2016 Addition of GAM to Muller cell culture repressed insulin-induced activation of the Akt/mTORC1 signaling pathway. Glucosamine 12-15 AKT serine/threonine kinase 1 Homo sapiens 83-86 26852666-8 2016 Instead, GAM induced ER stress and subsequent expression of the protein Regulated in DNA Damage and Development (REDD1), which was necessary for GAM to repress insulin-stimulated phosphorylation of Akt on Thr308. Glucosamine 9-12 AKT serine/threonine kinase 1 Homo sapiens 198-201 32510127-7 2020 Furthermore, DhHP-6 also activated PI3K/AKT and AMPK pathway in glucosamine-induced HepG2 cells. Glucosamine 64-75 AKT serine/threonine kinase 1 Homo sapiens 40-43 28713921-8 2017 These observations suggested that glucosamine modulated A549 cell proliferation, possibly via O-GlcNAc modification-induced downregulation of the PI3K/AKT and MAPK/ERK pathways and their downstream signaling molecules, FOXO1 and FOXO3. Glucosamine 34-45 AKT serine/threonine kinase 1 Homo sapiens 151-154 23935944-12 2013 However, the PI-3 kinase inhibitor LY294002, which abolished the effect of PUGNAc+glucosamine on Akt phosphorylation, did not impair the protective effects of PUGNAc+glucosamine against tamoxifen-induced cell death. Glucosamine 82-93 AKT serine/threonine kinase 1 Homo sapiens 97-100 24438088-0 2014 The novel IGF-IR/Akt-dependent anticancer activities of glucosamine. Glucosamine 56-67 AKT serine/threonine kinase 1 Homo sapiens 17-20 24438088-2 2014 Because the IGF-1R/Akt pathway is a common upstream regulator of p70S6K, HIF-1alpha, and COX-2, we hypothesized that glucosamine inhibits cancer cell proliferation through this pathway. Glucosamine 117-128 AKT serine/threonine kinase 1 Homo sapiens 19-22 24438088-4 2014 RESULTS: We found that glucosamine inhibited the growth of human non-small cell lung cancer (NSCLC) cells and negatively regulated the expression of IGF-1R and phosphorylation of Akt. Glucosamine 23-34 AKT serine/threonine kinase 1 Homo sapiens 179-182 24438088-8 2014 CONCLUSIONS: Taken together, our results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer. Glucosamine 92-103 AKT serine/threonine kinase 1 Homo sapiens 75-78 17136481-0 2007 Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells. Glucosamine 0-11 AKT serine/threonine kinase 1 Homo sapiens 32-35 23606170-10 2013 This was associated with glucosamine-mediated inhibition of the Akt/FoxO3/mammalian target of rapamycin pathway. Glucosamine 25-36 AKT serine/threonine kinase 1 Homo sapiens 64-67 18340449-7 2008 It was also found that GLN alone, but also synergistically with IL-1beta, was able to activate the Akt pathway. Glucosamine 23-26 AKT serine/threonine kinase 1 Homo sapiens 99-102 18340449-10 2008 The chondroprotective effect of GLN through the decrease in MMP-3 production and stimulation of proteoglycan synthesis may follow another potential signaling pathway of Akt. Glucosamine 32-35 AKT serine/threonine kinase 1 Homo sapiens 169-172 23594311-9 2013 The expression of FasL and activated caspases, particularly caspase-3, was increased, whereas the phosphorylation of PI3K, Akt and NF-kappaB was decreased by GlcN treatment. Glucosamine 158-162 AKT serine/threonine kinase 1 Homo sapiens 123-126 23594311-10 2013 Therefore, in addition to down-regulating TCR signalling and promoting CTLA-4 expression, GlcN may also suppress T cell function by enhancing apoptosis of activated T cells, through both extrinsic and intrinsic apoptotic signalling pathways, which were regulated by the inhibition of PI3K/Akt and NF-kappaB phosphorylation. Glucosamine 90-94 AKT serine/threonine kinase 1 Homo sapiens 289-292 18340449-0 2008 Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways. Glucosamine 29-40 AKT serine/threonine kinase 1 Homo sapiens 68-71 18174452-9 2008 Akt was recognized by an O-GlcNAc specific lectin, and glucosamine increased the amounts of Akt protein in these lectin precipitates. Glucosamine 55-66 AKT serine/threonine kinase 1 Homo sapiens 92-95 17136481-3 2007 Herein, we investigate the effects of increased HBP flux on Akt activation in a human astroglial cells line using glucosamine, a compound commonly used to mimic hyperglycemic conditions by increasing HBP flux. Glucosamine 114-125 AKT serine/threonine kinase 1 Homo sapiens 60-63 17136481-4 2007 Cellular treatment with 8 mM glucosamine resulted in a 96.8% +/- 24.6 increase in Akt phosphorylation after 5 h of treatment that remained elevated throughout the 9-h time course. Glucosamine 29-40 AKT serine/threonine kinase 1 Homo sapiens 82-85 11751589-3 2002 In this study we assessed whether ceramide and/or glucosamine, two known insulin-signaling antagonists, also affected the PI3K/Akt-independent signal. Glucosamine 50-61 AKT serine/threonine kinase 1 Homo sapiens 127-130 15059979-7 2004 BADGP reversed the glucosamine-induced reduction in insulin-stimulated phosphorylation of IR, IRS-1, IRS-2, Akt, GSK-3, and FOXO1a. Glucosamine 19-30 AKT serine/threonine kinase 1 Homo sapiens 108-111 11906162-5 2002 These data suggest that an Akt-independent mechanism is operative in glucosamine-induced insulin resistance and glucosamine impairs glucose transport stimulated by various stimuli involving and not involving Akt activation. Glucosamine 69-80 AKT serine/threonine kinase 1 Homo sapiens 27-30 11906162-1 2002 In 3T3-L1 adipocytes, we previously reported that glucosamine impairs insulin stimulation of glucose transport, which is accompanied by impaired insulin stimulation of serine/threonine kinase Akt. Glucosamine 50-61 AKT serine/threonine kinase 1 Homo sapiens 192-195 35191133-0 2022 Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway. Glucosamine 0-11 AKT serine/threonine kinase 1 Homo sapiens 108-111 10644543-4 2000 Glucosamine, however, severely impaired insulin stimulation of Akt. Glucosamine 0-11 AKT serine/threonine kinase 1 Homo sapiens 63-66 34410099-7 2021 The results displayed that tFNAs could increase glucose uptake and ameliorate IR by activating the IRS-1/PI3K/Akt pathway in glucosamine (GlcN)-stimulated HepG2 cells. Glucosamine 138-142 AKT serine/threonine kinase 1 Homo sapiens 110-113 35191133-11 2022 In addition, GlcN decreased the mammalian target of rapamycin (mTOR) and protein kinase B (Akt). Glucosamine 13-17 AKT serine/threonine kinase 1 Homo sapiens 91-94 35191133-12 2022 However, the Akt activator (SC79) suppressed the autophagy level induced by GlcN in osteoblasts. Glucosamine 76-80 AKT serine/threonine kinase 1 Homo sapiens 13-16 35191133-13 2022 Consequently, the antioxidant effects of GlcN were mediated, at least in part, by enhancing autophagy through the Akt/mTOR pathway. Glucosamine 41-45 AKT serine/threonine kinase 1 Homo sapiens 114-117