PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9417069-7	1998	Importantly, inhibition of glucokinase activity by glucosamine infusion blunted both the stimulation of Glc-6-Pase and the inhibition of PEPCK gene expression by Glc, suggesting that an intrahepatic signal (metabolite) generated by the metabolism of glucose at or beyond Glc-6-P was responsible for the regulatory effect of Glc.	Glucosamine	51-62	glucokinase	Rattus norvegicus	27-38	
11893929-0	2002	Glucosamine-induced beta-cell dysfunction: a possible involvement of glucokinase or glucose-transporter type 2.	Glucosamine	0-11	glucokinase	Rattus norvegicus	69-80	
11893929-6	2002	In glucosamine-cultured islets, glucose-transporter type 2 or glucokinase mRNA expression decreased, whereas hexokinase mRNA increased.	Glucosamine	3-14	glucokinase	Rattus norvegicus	62-73	
11390407-3	2001	Overexpression of GFAT or treatment with glucosamine results in impaired glucose-stimulated insulin secretion and reduction in the expression levels of several beta-cell specific genes (insulin, GLUT2, and glucokinase).	Glucosamine	41-52	glucokinase	Rattus norvegicus	206-217	
7755569-1	1995	Glucosamine, a potent inhibitor of glucokinase (hexokinase IV or D), was used to estimate the contribution of this enzyme to glucose phosphorylation in freshly isolated rat hepatocytes and its sensitivity to fructose 6-phosphate in situ.	Glucosamine	0-11	glucokinase	Rattus norvegicus	35-46	
7755569-0	1995	Glucosamine-sensitive and -insensitive detritiation of [2-3H]glucose in isolated rat hepatocytes: a study of the contributions of glucokinase and glucose-6-phosphatase.	Glucosamine	0-11	glucokinase	Rattus norvegicus	130-141	
8826967-0	1996	Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.	Glucosamine	0-11	glucokinase	Rattus norvegicus	40-51	
8826967-3	1996	We first determined the concentration of the competitive inhibitor, glucosamine (GlcN), which decreases hepatic GK activity by approximately 60% in vitro.	Glucosamine	68-79	glucokinase	Rattus norvegicus	112-114	
8826967-3	1996	We first determined the concentration of the competitive inhibitor, glucosamine (GlcN), which decreases hepatic GK activity by approximately 60% in vitro.	Glucosamine	81-85	glucokinase	Rattus norvegicus	112-114	
8826967-6	1996	Our results support the notion that hepatic GK activity is indeed decreased by GlcN in vivo.	Glucosamine	79-83	glucokinase	Rattus norvegicus	44-46	
914798-1	1977	A kinase activity for D-glucosamine without inhibition by glucose in rat liver and its possible identity with glucokinase.	Glucosamine	22-35	glucokinase	Rattus norvegicus	110-121	
7926284-0	1994	Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats.	Glucosamine	0-11	glucokinase	Rattus norvegicus	21-32	
7926284-4	1994	In this study, the effects of glucosamine on glucokinase activity and on islet function were assessed in vitro and in vivo.	Glucosamine	30-41	glucokinase	Rattus norvegicus	45-56	
7926284-5	1994	Glucosamine (5 mmol/l) reduced glucokinase activity in islet homogenate and diminished the insulin response to glucose (200 mg/dl) by isolated islets, whereas the response to arginine (20 mmol/l at 100 mg/dl glucose) was unaffected.	Glucosamine	0-11	glucokinase	Rattus norvegicus	31-42	
7926284-13	1994	The results indicate that glucosamine inhibits beta-cell glucokinase activity in vitro.	Glucosamine	26-37	glucokinase	Rattus norvegicus	57-68	
7926284-15	1994	We conclude that glucosamine, probably via a reduction of glucokinase activity, impairs insulin secretion in a manner comparable to that seen in NIDDM.	Glucosamine	17-28	glucokinase	Rattus norvegicus	58-69	
21440571-4	2011	We previously reported that antagonism of centrally expressed GK by administration of glucosamine (GSN) was sufficient to induce protective glucoprivic feeding in rats.	Glucosamine	86-97	glucokinase	Rattus norvegicus	62-64	
1275893-2	1976	After attachment to CNBr-activated Sepharose 4B, this derivative was able to remove glucokinase quantitatively from crude liver extracts and release it when the columns were developed with glucose, glucosamine, N-acetyl-glucosamine or KC1.	Glucosamine	198-209	glucokinase	Rattus norvegicus	84-95	
1158856-0	1975	Phosphorylation of D-glucosamine by rat liver glucokinase.	Glucosamine	19-32	glucokinase	Rattus norvegicus	46-57	
1158856-2	1975	Results suggested that glucosamine may be phosphorylated by high Km hexokinase, i.e. glucokinase [EC 2.7.1.2].	Glucosamine	23-34	glucokinase	Rattus norvegicus	85-96	
1158856-5	1975	The apparent Km of glucokinase for glucosamine was estimated as 8 mM, which is ten times that of low Km hexokinase.	Glucosamine	35-46	glucokinase	Rattus norvegicus	19-30	
21440571-0	2011	Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons.	Glucosamine	22-33	glucokinase	Rattus norvegicus	0-11	
21440571-4	2011	We previously reported that antagonism of centrally expressed GK by administration of glucosamine (GSN) was sufficient to induce protective glucoprivic feeding in rats.	Glucosamine	99-102	glucokinase	Rattus norvegicus	62-64	
20179264-3	2010	Here we investigated the effects of intracerebroventricular (ICV) infusion of glucosamine (GSN), a GK inhibitor, on food intake at normoglycemia and protective feeding responses during glucoprivation and hypoglycemia in chronically catheterized rats.	Glucosamine	78-89	glucokinase	Rattus norvegicus	99-101	
20179264-4	2010	ICV infusion of either GSN or mannoheptulose, a structurally different GK inhibitor, dose-dependently stimulated feeding at normoglycemia.	Glucosamine	23-26	glucokinase	Rattus norvegicus	71-73