PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1158856-0 1975 Phosphorylation of D-glucosamine by rat liver glucokinase. Glucosamine 19-32 glucokinase Rattus norvegicus 46-57 1275893-2 1976 After attachment to CNBr-activated Sepharose 4B, this derivative was able to remove glucokinase quantitatively from crude liver extracts and release it when the columns were developed with glucose, glucosamine, N-acetyl-glucosamine or KC1. Glucosamine 198-209 glucokinase Rattus norvegicus 84-95 914798-1 1977 A kinase activity for D-glucosamine without inhibition by glucose in rat liver and its possible identity with glucokinase. Glucosamine 22-35 glucokinase Rattus norvegicus 110-121 1158856-2 1975 Results suggested that glucosamine may be phosphorylated by high Km hexokinase, i.e. glucokinase [EC 2.7.1.2]. Glucosamine 23-34 glucokinase Rattus norvegicus 85-96 1158856-5 1975 The apparent Km of glucokinase for glucosamine was estimated as 8 mM, which is ten times that of low Km hexokinase. Glucosamine 35-46 glucokinase Rattus norvegicus 19-30 21440571-0 2011 Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons. Glucosamine 22-33 glucokinase Rattus norvegicus 0-11 21440571-4 2011 We previously reported that antagonism of centrally expressed GK by administration of glucosamine (GSN) was sufficient to induce protective glucoprivic feeding in rats. Glucosamine 86-97 glucokinase Rattus norvegicus 62-64 21440571-4 2011 We previously reported that antagonism of centrally expressed GK by administration of glucosamine (GSN) was sufficient to induce protective glucoprivic feeding in rats. Glucosamine 99-102 glucokinase Rattus norvegicus 62-64 11893929-0 2002 Glucosamine-induced beta-cell dysfunction: a possible involvement of glucokinase or glucose-transporter type 2. Glucosamine 0-11 glucokinase Rattus norvegicus 69-80 20179264-3 2010 Here we investigated the effects of intracerebroventricular (ICV) infusion of glucosamine (GSN), a GK inhibitor, on food intake at normoglycemia and protective feeding responses during glucoprivation and hypoglycemia in chronically catheterized rats. Glucosamine 78-89 glucokinase Rattus norvegicus 99-101 20179264-4 2010 ICV infusion of either GSN or mannoheptulose, a structurally different GK inhibitor, dose-dependently stimulated feeding at normoglycemia. Glucosamine 23-26 glucokinase Rattus norvegicus 71-73 11893929-6 2002 In glucosamine-cultured islets, glucose-transporter type 2 or glucokinase mRNA expression decreased, whereas hexokinase mRNA increased. Glucosamine 3-14 glucokinase Rattus norvegicus 62-73 7755569-1 1995 Glucosamine, a potent inhibitor of glucokinase (hexokinase IV or D), was used to estimate the contribution of this enzyme to glucose phosphorylation in freshly isolated rat hepatocytes and its sensitivity to fructose 6-phosphate in situ. Glucosamine 0-11 glucokinase Rattus norvegicus 35-46 8826967-0 1996 Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Glucosamine 0-11 glucokinase Rattus norvegicus 40-51 8826967-3 1996 We first determined the concentration of the competitive inhibitor, glucosamine (GlcN), which decreases hepatic GK activity by approximately 60% in vitro. Glucosamine 68-79 glucokinase Rattus norvegicus 112-114 8826967-3 1996 We first determined the concentration of the competitive inhibitor, glucosamine (GlcN), which decreases hepatic GK activity by approximately 60% in vitro. Glucosamine 81-85 glucokinase Rattus norvegicus 112-114 8826967-6 1996 Our results support the notion that hepatic GK activity is indeed decreased by GlcN in vivo. Glucosamine 79-83 glucokinase Rattus norvegicus 44-46 11390407-3 2001 Overexpression of GFAT or treatment with glucosamine results in impaired glucose-stimulated insulin secretion and reduction in the expression levels of several beta-cell specific genes (insulin, GLUT2, and glucokinase). Glucosamine 41-52 glucokinase Rattus norvegicus 206-217 9417069-7 1998 Importantly, inhibition of glucokinase activity by glucosamine infusion blunted both the stimulation of Glc-6-Pase and the inhibition of PEPCK gene expression by Glc, suggesting that an intrahepatic signal (metabolite) generated by the metabolism of glucose at or beyond Glc-6-P was responsible for the regulatory effect of Glc. Glucosamine 51-62 glucokinase Rattus norvegicus 27-38 7755569-0 1995 Glucosamine-sensitive and -insensitive detritiation of [2-3H]glucose in isolated rat hepatocytes: a study of the contributions of glucokinase and glucose-6-phosphatase. Glucosamine 0-11 glucokinase Rattus norvegicus 130-141 7926284-0 1994 Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Glucosamine 0-11 glucokinase Rattus norvegicus 21-32 7926284-4 1994 In this study, the effects of glucosamine on glucokinase activity and on islet function were assessed in vitro and in vivo. Glucosamine 30-41 glucokinase Rattus norvegicus 45-56 7926284-5 1994 Glucosamine (5 mmol/l) reduced glucokinase activity in islet homogenate and diminished the insulin response to glucose (200 mg/dl) by isolated islets, whereas the response to arginine (20 mmol/l at 100 mg/dl glucose) was unaffected. Glucosamine 0-11 glucokinase Rattus norvegicus 31-42 7926284-13 1994 The results indicate that glucosamine inhibits beta-cell glucokinase activity in vitro. Glucosamine 26-37 glucokinase Rattus norvegicus 57-68 7926284-15 1994 We conclude that glucosamine, probably via a reduction of glucokinase activity, impairs insulin secretion in a manner comparable to that seen in NIDDM. Glucosamine 17-28 glucokinase Rattus norvegicus 58-69