PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28558682-9 2017 Meanwhile, the expression of several regulators that contribute to G1/S phased transition, such as Cyclin D1, CDK4 and CDK6, were significantly down-regulated with the up-regulation of cell cycle inhibitors, p21 and p53, after treatment with glucosamine. Glucosamine 242-253 H3 histone pseudogene 16 Homo sapiens 208-211 23128353-6 2013 Glucosamine at 50 mM was demonstrated to elevate both the mRNA and protein expression of p53 and heme oxygenase-1 (HO-1), but also caused a reduction in p21 protein expression. Glucosamine 0-11 H3 histone pseudogene 16 Homo sapiens 153-156 23128353-7 2013 In addition, glucosamine attenuated p21 protein stability via the proteasomal proteolytic pathway, as well as inducing p21 nuclear accumulation. Glucosamine 13-24 H3 histone pseudogene 16 Homo sapiens 36-39 23128353-7 2013 In addition, glucosamine attenuated p21 protein stability via the proteasomal proteolytic pathway, as well as inducing p21 nuclear accumulation. Glucosamine 13-24 H3 histone pseudogene 16 Homo sapiens 119-122 23128353-8 2013 Altogether, our results suggest that a high dose of glucosamine may inhibit cell proliferation through apoptosis and disturb cell cycle progression with a halt at G(0)/G(1) phase, and that this occurs, at least in part, by a reduction in Rb phosphorylation together with modulation of p21, p53 and HO-1 expression, and nuclear p21 accumulation. Glucosamine 52-63 H3 histone pseudogene 16 Homo sapiens 285-288 23128353-8 2013 Altogether, our results suggest that a high dose of glucosamine may inhibit cell proliferation through apoptosis and disturb cell cycle progression with a halt at G(0)/G(1) phase, and that this occurs, at least in part, by a reduction in Rb phosphorylation together with modulation of p21, p53 and HO-1 expression, and nuclear p21 accumulation. Glucosamine 52-63 H3 histone pseudogene 16 Homo sapiens 327-330