PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31618900-7 2019 In addition to the activation of apoptotic pathways, TRAIL-mediated inflammatory responses were attenuated by GlcN pretreatment reducing nuclear NF-kB levels and the expression of downstream target genes IL-6 and IL-8. Glucosamine 110-114 interleukin 6 Homo sapiens 204-208 33192537-6 2020 Results: HG and glucosamine upregulated OGT mRNA and protein expression, protein O-GlcNAcylation, and IL-6 mRNA and protein expression. Glucosamine 16-27 interleukin 6 Homo sapiens 102-106 32440348-4 2020 Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL-6 production, but also phosphorylation of ERK1/2. Glucosamine 52-56 interleukin 6 Homo sapiens 133-137 32440348-5 2020 Similarly, combination of GlcN + GlcNAc significantly suppressed IL-6 production and phosphorylation of ERK1/2. Glucosamine 26-30 interleukin 6 Homo sapiens 65-69 27776166-7 2016 Furthermore, GlcN suppressed the expression of proinflammatory cytokine genes (such as IL-6, IL-8, IL-24 and TNF-alpha genes). Glucosamine 13-17 interleukin 6 Homo sapiens 87-91 28862770-7 2018 CONCLUSIONS: Both strategies alleviated symptoms in short term, but the patients treated with GS benefited more than those with placebo in long term, which may be due to the suppression of IL-1beta and IL-6 and the stimulation of TGF-beta. Glucosamine 94-96 interleukin 6 Homo sapiens 202-206 30713180-1 2018 AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2. Glucosamine 33-44 interleukin 6 Homo sapiens 212-216 27927986-4 2017 Moreover, GlcN suppressed LPS-induced up-regulation of COX-2, IL-6, and TNF-alpha mRNAs under 25 mm glucose conditions yet did not inhibit up-regulation under 5 mm glucose conditions. Glucosamine 10-14 interleukin 6 Homo sapiens 62-66 34867400-6 2021 Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels. Glucosamine 102-113 interleukin 6 Homo sapiens 214-217 24932134-9 2014 RESULTS: In DU145 cells glucosamine reduced the N-glycosylation of gp130, decreased IL-6 binding to cells and impaired the phosphorylation of JAK2, SHP2 and STAT3. Glucosamine 24-35 interleukin 6 Homo sapiens 84-88 20307528-5 2010 The RT-PCR, real-time PCR, and ELISA analyses demonstrated that LPS-induced mRNAs encoding IL-6 and IL-8 and the subsequent secretion of IL-6 and IL-8 were inhibited by glucosamine treatment. Glucosamine 169-180 interleukin 6 Homo sapiens 91-95 20307528-5 2010 The RT-PCR, real-time PCR, and ELISA analyses demonstrated that LPS-induced mRNAs encoding IL-6 and IL-8 and the subsequent secretion of IL-6 and IL-8 were inhibited by glucosamine treatment. Glucosamine 169-180 interleukin 6 Homo sapiens 137-141 15258595-3 2004 Dendrimer glucosamine inhibited Toll-like receptor 4-mediated lipopolysaccharide induced synthesis of pro-inflammatory chemokines (MIP-1 alpha, MIP-1 beta, IL-8) and cytokines (TNF-alpha, IL-1 beta, IL-6) from human dendritic cells and macrophages but allowed upregulation of the costimulatory molecules CD25, CD80, CD83 and CD86. Glucosamine 10-21 interleukin 6 Homo sapiens 199-203 25662545-0 2015 Effects of glucosamine-chondroitin combination on synovial fluid IL-1beta, IL-6, TNF-alpha and PGE2 levels in internal derangements of temporomandibular joint. Glucosamine 11-22 interleukin 6 Homo sapiens 75-79 25662545-14 2015 CONCLUSIONS: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1beta and IL6 levels in internal derangements of TMJ compared to tramadol. Glucosamine 61-72 interleukin 6 Homo sapiens 174-177 22966296-0 2010 Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine 57-68 interleukin 6 Homo sapiens 19-23 22966296-0 2010 Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine 158-169 interleukin 6 Homo sapiens 19-23 22966296-5 2010 Our data showed that the expression of IL-6, IL-8, TNF-alpha and IL-1beta was decreased by glucosamine treatment in the HaCaT cells. Glucosamine 91-102 interleukin 6 Homo sapiens 39-43 22966296-9 2010 Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta expression in the HaCaT cells. Glucosamine 24-35 interleukin 6 Homo sapiens 67-71 16822504-3 2006 We used flow cytometry and an ARPE-19 cell model to determine the effect of GS on the production of ICAM-1 in response to IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha plus IL-1beta, TNF-alpha plus IL-6, and TNF-alpha plus interferon (IFN)-gamma. Glucosamine 76-78 interleukin 6 Homo sapiens 132-136 34754325-11 2021 And it was found that IL6 was lowly expressed in the group with GlcN-treated MH7A cells, while DDIT3 was highly expressed. Glucosamine 64-68 interleukin 6 Homo sapiens 22-25