PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11112445-2	2000	Based on recent findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) mediates the pathogenesis of arthritis, we hypothesized that glucosamine may inhibit NO synthesis.	Glucosamine	162-173	nitric oxide synthase 2	Rattus norvegicus	72-93	
30021375-5	2018	NF-kappaB, and iNOS protein levels were decreased by 47.7% and 39.5%, respectively, by glucosamine plus vitamin E supplementation.	Glucosamine	87-98	nitric oxide synthase 2	Rattus norvegicus	15-19	
18719082-14	2008	In LPS-stimulated macrophage RAW cell culture, GS inhibited the production of NO and PG-E2, the expression of iNOS and COX-2, and the activation of NF-kappaB.	Glucosamine	47-49	nitric oxide synthase 2	Rattus norvegicus	110-114	
23898954-9	2013	Overexpression of the p65 subunit restored the inhibitory action of glucosamine on cytomix-regulated NO production and iNOS expression.	Glucosamine	68-79	nitric oxide synthase 2	Rattus norvegicus	119-123	
11112445-2	2000	Based on recent findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) mediates the pathogenesis of arthritis, we hypothesized that glucosamine may inhibit NO synthesis.	Glucosamine	162-173	nitric oxide synthase 2	Rattus norvegicus	95-99	
11112445-5	2000	When cultured macrophages were treated with LPS (1 microg/ml) to induce iNOS expression, addition of 0.1, 0.5, 1, and 2 mM d-glucosamine decreased NO production by 18, 38, 60, and 89%, respectively.	Glucosamine	123-136	nitric oxide synthase 2	Rattus norvegicus	72-76	
11112445-6	2000	Glucosamine had no effect on cellular arginine, NADPH or tetrahydrobiopterin concentrations, but dose-dependently suppressed iNOS protein expression.	Glucosamine	0-11	nitric oxide synthase 2	Rattus norvegicus	125-129	
11112445-7	2000	Similar decreases in iNOS protein occurred in spleen, lung, and peritoneal macrophages of glucosamine-treated rats.	Glucosamine	90-101	nitric oxide synthase 2	Rattus norvegicus	21-25	
11112445-8	2000	These studies demonstrate that glucosamine is a novel inhibitor of inducible NO synthesis via inhibition of iNOS protein expression, and provide a biochemical basis for the use of glucosamine in treating chronic inflammatory diseases such as arthritis.	Glucosamine	31-42	nitric oxide synthase 2	Rattus norvegicus	108-112	
35109948-9	2022	Increased mRNA expression of iNOS and TNF-alpha was significantly reduced in the spinal cord of CCI animals by glucosamine (500, 1000, 2000 mg/kg) in the prophylactic regimen.	Glucosamine	111-122	nitric oxide synthase 2	Rattus norvegicus	29-33	
32198574-11	2020	Furthermore, anserine plus glucosamine significantly reduced the mRNA and protein levels of NF-kappaB and iNOS compared to the control, anserine, and glucosamine groups.	Glucosamine	27-38	nitric oxide synthase 2	Rattus norvegicus	106-110	
32198574-11	2020	Furthermore, anserine plus glucosamine significantly reduced the mRNA and protein levels of NF-kappaB and iNOS compared to the control, anserine, and glucosamine groups.	Glucosamine	150-161	nitric oxide synthase 2	Rattus norvegicus	106-110