PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11112445-2 2000 Based on recent findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) mediates the pathogenesis of arthritis, we hypothesized that glucosamine may inhibit NO synthesis. Glucosamine 162-173 nitric oxide synthase 2 Rattus norvegicus 72-93 18719082-14 2008 In LPS-stimulated macrophage RAW cell culture, GS inhibited the production of NO and PG-E2, the expression of iNOS and COX-2, and the activation of NF-kappaB. Glucosamine 47-49 nitric oxide synthase 2 Rattus norvegicus 110-114 11112445-2 2000 Based on recent findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) mediates the pathogenesis of arthritis, we hypothesized that glucosamine may inhibit NO synthesis. Glucosamine 162-173 nitric oxide synthase 2 Rattus norvegicus 95-99 11112445-5 2000 When cultured macrophages were treated with LPS (1 microg/ml) to induce iNOS expression, addition of 0.1, 0.5, 1, and 2 mM d-glucosamine decreased NO production by 18, 38, 60, and 89%, respectively. Glucosamine 123-136 nitric oxide synthase 2 Rattus norvegicus 72-76 11112445-6 2000 Glucosamine had no effect on cellular arginine, NADPH or tetrahydrobiopterin concentrations, but dose-dependently suppressed iNOS protein expression. Glucosamine 0-11 nitric oxide synthase 2 Rattus norvegicus 125-129 11112445-7 2000 Similar decreases in iNOS protein occurred in spleen, lung, and peritoneal macrophages of glucosamine-treated rats. Glucosamine 90-101 nitric oxide synthase 2 Rattus norvegicus 21-25 11112445-8 2000 These studies demonstrate that glucosamine is a novel inhibitor of inducible NO synthesis via inhibition of iNOS protein expression, and provide a biochemical basis for the use of glucosamine in treating chronic inflammatory diseases such as arthritis. Glucosamine 31-42 nitric oxide synthase 2 Rattus norvegicus 108-112 32198574-11 2020 Furthermore, anserine plus glucosamine significantly reduced the mRNA and protein levels of NF-kappaB and iNOS compared to the control, anserine, and glucosamine groups. Glucosamine 27-38 nitric oxide synthase 2 Rattus norvegicus 106-110 35109948-9 2022 Increased mRNA expression of iNOS and TNF-alpha was significantly reduced in the spinal cord of CCI animals by glucosamine (500, 1000, 2000 mg/kg) in the prophylactic regimen. Glucosamine 111-122 nitric oxide synthase 2 Rattus norvegicus 29-33 32198574-11 2020 Furthermore, anserine plus glucosamine significantly reduced the mRNA and protein levels of NF-kappaB and iNOS compared to the control, anserine, and glucosamine groups. Glucosamine 150-161 nitric oxide synthase 2 Rattus norvegicus 106-110 30021375-5 2018 NF-kappaB, and iNOS protein levels were decreased by 47.7% and 39.5%, respectively, by glucosamine plus vitamin E supplementation. Glucosamine 87-98 nitric oxide synthase 2 Rattus norvegicus 15-19 23898954-9 2013 Overexpression of the p65 subunit restored the inhibitory action of glucosamine on cytomix-regulated NO production and iNOS expression. Glucosamine 68-79 nitric oxide synthase 2 Rattus norvegicus 119-123