PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34611521-3 2021 Recombinant human ACE2 (rhACE2) functionalized onto the surface of cytomimetic particles binds the receptor binding domain (RBD) of recombinant SARS-CoV-2 spike protein with high affinity and demonstrated a stoichiometric advantage over the use of soluble rhACE2. rhace2 24-30 angiotensin converting enzyme 2 Homo sapiens 18-22 32817951-5 2020 In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 with SARS-CoV-2 Spike (RBD) protein. rhace2 133-139 angiotensin converting enzyme 2 Homo sapiens 100-131 32864572-7 2020 We presume that restoration of normal functioning of renin-angiotensin system with recombinant human angiotensin-converting enzyme 2 (rhACE2), angiotensin (1-7) and angiotensin (1-9) may be an effective therapeutic measure but studies will be required to test this hypothesis and explore its possible role in treatment of COVID-19. rhace2 134-140 angiotensin converting enzyme 2 Homo sapiens 101-132 33732940-5 2021 In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin-converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 with SARS-CoV-2 Spike (RBD) protein. rhace2 133-139 angiotensin converting enzyme 2 Homo sapiens 100-131 33400951-4 2021 This report compares the ability of recombinant human ACE2 (rhACE2) to metabolize Ang III, Ang IV and Ang V, (4-8 pentapeptide) relative to Ang II to form corresponding des-omega-Phe metabolites. rhace2 60-66 angiotensin converting enzyme 2 Homo sapiens 54-58 33135833-2 2021 HYPOTHESIS/OBJECTIVES: Angiotensin receptor blockers (ARBs) would alter balance of APs and differences would be magnified in vitro by incubation of plasma samples with recombinant human ACE2 (rhACE2). rhace2 192-198 angiotensin converting enzyme 2 Homo sapiens 186-190 32428864-5 2020 In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine). rhace2 176-182 angiotensin converting enzyme 2 Homo sapiens 61-65 32428864-5 2020 In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine). rhace2 176-182 angiotensin converting enzyme 2 Homo sapiens 146-150 32428864-5 2020 In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine). rhace2 176-182 angiotensin converting enzyme 2 Homo sapiens 146-150 32428864-5 2020 In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine). rhace2 176-182 angiotensin converting enzyme 2 Homo sapiens 146-150 31254308-3 2019 Equilibrium concentrations of renin angiotensin aldosterone system (RAAS) APs differ in dogs with heart disease compared to healthy dogs and recombinant human ACE2 (rhACE2) alters relative concentrations of APs. rhace2 165-171 angiotensin converting enzyme 2 Homo sapiens 159-163