PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30038944-1	2018	Recent work suggests the selective Cox-2 inhibitor celecoxib delays progression to androgen independence in hormone sensitive prostate cancer (HSPC) through inhibition of the androgen receptor (AR) and ErbB signaling.	Celecoxib	51-60	androgen receptor	Homo sapiens	175-192	
12917209-0	2003	The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells.	Celecoxib	67-76	androgen receptor	Homo sapiens	100-117	
30038944-1	2018	Recent work suggests the selective Cox-2 inhibitor celecoxib delays progression to androgen independence in hormone sensitive prostate cancer (HSPC) through inhibition of the androgen receptor (AR) and ErbB signaling.	Celecoxib	51-60	androgen receptor	Homo sapiens	194-196	
28450158-7	2017	Lastly, Celecoxib directly regulated AR transcription and translation independent of ErbB activation by downregulating the RNA binding protein heterogeneous nuclear ribonucleoprotein K (hnRNP K).	Celecoxib	8-17	androgen receptor	Homo sapiens	37-39	
28450158-0	2017	The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer.	Celecoxib	63-72	androgen receptor	Homo sapiens	20-37	
28450158-2	2017	The purpose of this work was to determine the ability of the COX-2 inhibitor Celecoxib to modulate the EGFR-AR signaling pathway in androgen-dependent PCa cells and to provide a rationale for its beneficial use in chemopreventive strategies.	Celecoxib	77-86	androgen receptor	Homo sapiens	108-110	
28450158-8	2017	The simultaneous suppression of ErbB kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.	Celecoxib	71-80	androgen receptor	Homo sapiens	143-145	
24518515-0	2014	EP2 signaling mediates suppressive effects of celecoxib on androgen receptor expression and cell proliferation in prostate cancer.	Celecoxib	46-55	androgen receptor	Homo sapiens	59-76	
27105861-0	2016	Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin.	Celecoxib	139-148	androgen receptor	Homo sapiens	51-68	
24518515-6	2014	RESULTS: Celecoxib induced apoptosis and downregulated EP2, CREB and androgen receptor (AR).	Celecoxib	9-18	androgen receptor	Homo sapiens	69-86	
24518515-6	2014	RESULTS: Celecoxib induced apoptosis and downregulated EP2, CREB and androgen receptor (AR).	Celecoxib	9-18	androgen receptor	Homo sapiens	88-90	
24518515-8	2014	Furthermore, EP2 and CREB knockdown induced AR downregulation, indicating that AR suppression by celecoxib is mediated by EP2/CREB signaling.	Celecoxib	97-106	androgen receptor	Homo sapiens	44-46	
24518515-8	2014	Furthermore, EP2 and CREB knockdown induced AR downregulation, indicating that AR suppression by celecoxib is mediated by EP2/CREB signaling.	Celecoxib	97-106	androgen receptor	Homo sapiens	79-81	
24518515-9	2014	CONCLUSIONS: Celecoxib exerts antitumor activity through EP2 signaling regulating AR and COX-2 expression.	Celecoxib	13-22	androgen receptor	Homo sapiens	82-84