PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32464120-8	2020	Celecoxib decreased HAPI cell viability (6.25-100 muM), accompanied with increasing caspase-3/7 activation and ROS production, but in contrast to montelukast increased CysLT release and decreased PGE2 production.	Celecoxib	0-9	caspase 3	Rattus norvegicus	84-95	
34546832-7	2021	With increasing celecoxib doses (0.5, 1, or 1.5 mg/kg), the amount of apoptotic epithelial cells in the ileum of NEC rats gradually declined and Caspase-3 expression was reduced.	Celecoxib	16-25	caspase 3	Rattus norvegicus	145-154	
30658157-5	2019	Celecoxib also reversed the CSA-evoked (i) reductions in the tubular and glomerular protein expression of CSE and levels of H2S, prostaglandin E2 (PGE2), and total antioxidant capacity (TAC), and (ii) increases in inflammatory (tumor necrosis factor-alpha, TNF-alpha), fibrotic (transforming growth factor-beta1, TGF-beta1) and apoptotic (caspase-3) cytokines.	Celecoxib	0-9	caspase 3	Rattus norvegicus	339-348	
32821072-18	2020	Consistently, after celecoxib administration, the upregulation of TAA-induced hepatic apoptosis markers (caspase-12 and caspase-3) and CHOP were significantly inhibited.	Celecoxib	20-29	caspase 3	Rattus norvegicus	120-129	
30826485-4	2019	RESULTS: Both sCT and CLX ameliorated cartilage lesions, significantly increased aggrecan expression and decreased caspase-3 expression.	Celecoxib	22-25	caspase 3	Rattus norvegicus	115-124	
28526264-0	2017	Celecoxib aggravates cardiac apoptosis in L-NAME-induced pressure overload model in rats: Immunohistochemical determination of cardiac caspase-3, Mcl-1, Bax and Bcl-2.	Celecoxib	0-9	caspase 3	Rattus norvegicus	135-144	
17828456-10	2007	Apoptosis regression was observed in the amygdala of the Celecoxib group as shown by decreased number of TUNEL positive cells and by decreased of caspase-3 activation.	Celecoxib	57-66	caspase 3	Rattus norvegicus	146-155	
22495067-11	2012	The expression of activated caspase-3 in ulcers was increased and enhanced further by indomethacin, DFU, and SC-560, but not by celecoxib and valdecoxib.	Celecoxib	128-137	caspase 3	Rattus norvegicus	28-37	
18588373-11	2008	Nonetheless, celecoxib"s tendency to raise caspase 3 activities, suggested that it accelerates the apoptosis in hepatocytes of pain-suffering animals.	Celecoxib	13-22	caspase 3	Rattus norvegicus	43-52	
15238462-7	2004	In vivo, celecoxib reduced injury-induced phosphorylation of Akt and GSK, reduced VSMC proliferation, and increased caspase-3 activation and VSMC apoptosis at 3 days after injury, whereas aspirin had no effect.	Celecoxib	9-18	caspase 3	Rattus norvegicus	116-125	
12960143-13	2003	Most importantly, celecoxib-induced apoptosis was associated with down-regulation of COX-2, nuclear factor kappaBp65, and with activation of peroxisome proliferator-activated receptor gamma, apoptosis activating factor-1, and caspase-3.	Celecoxib	18-27	caspase 3	Rattus norvegicus	226-235