PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29991711-7	2018	Knockdown of Rictor or treatment with the Akt inhibitor MK-2206 attenuated senescence-associated beta-galactosidase (beta-gal) staining and expression of p53 and p21 proteins in the senescent endothelial cells, suggesting that mTORC2/Akt facilitates endothelial senescence.	MK 2206	56-63	H3 histone pseudogene 16	Homo sapiens	162-165	
24476133-7	2014	We observed that administration of MK-2206, an allosteric AKT inhibitor, increased levels of reactive oxygen species, up-regulated the microRNA miR-182 and several senescence-associated genes (including p16, p53, p21, and beta-galactosidase), and drove leiomyoma cells into stress-induced premature senescence (SIPS).	MK 2206	35-42	H3 histone pseudogene 16	Homo sapiens	213-216	
23797319-6	2013	The results of present study showed that MK-2206-induced G1-phase arrest was associated with a marked decrease in the protein expression of cyclin D1 with concomitant induction of p21 and p27.	MK 2206	41-48	H3 histone pseudogene 16	Homo sapiens	180-183