PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30544832-0	2018	Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors.	Donepezil	16-25	beta-secretase 1	Homo sapiens	58-63	
29966870-0	2018	Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors.	Donepezil	24-33	beta-secretase 1	Homo sapiens	61-67	
29966870-3	2018	Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site.	Donepezil	13-22	beta-secretase 1	Homo sapiens	78-84	
29966870-3	2018	Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site.	Donepezil	13-22	beta-secretase 1	Homo sapiens	225-231	
27858713-0	2017	Protein Expression of BACE1 is Downregulated by Donepezil in Alzheimer"s Disease Platelets.	Donepezil	48-57	beta-secretase 1	Homo sapiens	22-27	
27858713-9	2017	Nonetheless, a significant reduction in the protein expression of BACE1 was observed in patients treated with donepezil for 6 months.	Donepezil	110-119	beta-secretase 1	Homo sapiens	66-71	
27858713-11	2017	We further show that PSEN1 is decreased in AD platelets, and that the protein expression of BACE1 is downregulated by chronic treatment with donepezil.	Donepezil	141-150	beta-secretase 1	Homo sapiens	92-97	
26228694-4	2015	RESULTS: We report that donepezil, memantine, dimebon, Pre-084 and 4-IBP are neuritogenic while tacrine, rosemarinic acid, memoquin and a BACE1 inhibitor suppress neurite outgrowth of neurons.	Donepezil	24-33	beta-secretase 1	Homo sapiens	138-143	
17541560-13	2007	Among these, donepezil, besides being an acetylcholinesterase inhibitor, was also found to be a BACE-1 inhibitor that displayed submicromolar potency (170 nM).	Donepezil	13-22	beta-secretase 1	Homo sapiens	96-102	
30017317-0	2018	Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.	Donepezil	72-81	beta-secretase 1	Homo sapiens	109-115	
30017317-2	2018	The investigated compounds 10-13 displayed dual AChE and BACE-1 inhibitory activities in comparison to donepezil, the FDA-approved drug.	Donepezil	103-112	beta-secretase 1	Homo sapiens	57-63	
27190595-0	2016	Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors.	Donepezil	37-46	beta-secretase 1	Homo sapiens	74-80