PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22161694-1 2011 OBJECTIVES: To identify tasks that were sensitive to a temporary decline in cognitive performance after sleep deprivation and to investigate the ability of the acetylcholinesterase inhibitor donepezil to reverse any sleep deprivation-induced impairment. Donepezil 191-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 21621811-3 2011 The main class of medicines which are applied in AD is acetylcholinesterase inhibitors (AChEIs) like tacrine, donepezil, galantamine and rivastigmine that do not contribute to significant and long-term improvement in cognitive and behavioural functions. Donepezil 110-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Donepezil 160-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 21772691-4 2011 After ruling out other causes of resistance to non-depolarizing muscle relaxants, we concluded that acetylcholinesterase inhibitor donepezil was primarily responsible for inadequate muscle relaxation and delayed post-operative neuromuscular recovery. Donepezil 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 21699076-7 2011 Compounds 3a, 3b, 3c, and 3e showed stronger activity than the standard donepezil towards the inhibition of BChE, and the compound 3e showed stronger activity than donepezil towards AChE. Donepezil 164-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 21116228-3 2010 All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil. Donepezil 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 21299848-4 2011 Symptomatic treatments for moderate to severe Alzheimer"s disease are approved in the United States and include the acetylcholinesterase inhibitor donepezil and the glutamate receptor antagonist memantine. Donepezil 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 20664535-1 2010 The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer"s disease and vascular dementia. Donepezil 35-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 19935404-0 2010 Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography. Donepezil 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 20193764-2 2010 Of known interventions, psychopharmacology provides readily available options, such as the anti-dementia drugs, e.g. acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine. Donepezil 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 20401964-0 2010 Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples. Donepezil 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 20401964-9 2010 The IC(50) values of specific AChE and BChE inhibitors, donepezil and ethopropazine, in 1.2-fold diluted human whole blood were much higher than those in 120-fold diluted blood. Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 19962381-0 2010 Donepezil, an acetylcholinesterase inhibitor against Alzheimer"s dementia, promotes angiogenesis in an ischemic hindlimb model. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19962381-3 2010 Therefore, we assessed the hypothesis that the cholinergic modulator donepezil, an acetylcholinesterase inhibitor utilized in Alzheimer"s disease, exhibits beneficial effects, especially on the acceleration of angiogenesis. Donepezil 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 20196555-4 2010 In vitro tests on AChE showed that one of those compounds presented a very good inhibition activity, of the same order as Donepezil. Donepezil 122-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19935404-3 2010 The plasma IC50 value of donepezil was estimated from plasma donepezil concentrations and cerebral cortical mean AChE inhibition rates measured by positron emission tomography, using one-parameter model. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 19935404-4 2010 RESULTS: Donepezil reduced AChE activity uniformly in the cerebral cortex compared with the baseline in each AD patient, and the mean reduction rate in the cerebral cortex was 34.6%. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 19935404-7 2010 CONCLUSIONS: Once the plasma IC50 of donepezil is determined, the brain AChE inhibition rate could be estimated from the plasma concentration of donepezil in each subject based on the plasma IC50. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 19935404-7 2010 CONCLUSIONS: Once the plasma IC50 of donepezil is determined, the brain AChE inhibition rate could be estimated from the plasma concentration of donepezil in each subject based on the plasma IC50. Donepezil 145-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19836169-2 2010 Donepezil is a reversible AChE inhibitor that is clinically available and relatively selective for inhibiting AChE but not other cholinesterases. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 19836169-2 2010 Donepezil is a reversible AChE inhibitor that is clinically available and relatively selective for inhibiting AChE but not other cholinesterases. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 19836169-3 2010 Because AChE inhibitors have been shown to decrease the reinforcing effects of cocaine in animals, our hypothesis was that pretreatment with donepezil would attenuate the perceived value and other positive subjective effects of cocaine. Donepezil 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 19573265-1 2009 The acetylcholinesterase (AChE) inhibitor donepezil is also a sigma1 receptor agonist. Donepezil 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). Donepezil 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). Donepezil 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 20522977-0 2010 Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 20522977-1 2010 Although donepezil, a potent acetylcholinesterase (AChE) inhibitor, has been used to treat Alzheimer"s disease (AD) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 20522977-1 2010 Although donepezil, a potent acetylcholinesterase (AChE) inhibitor, has been used to treat Alzheimer"s disease (AD) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 19580698-5 2009 In the present study we investigated the impact of a 15-month treatment with the AChE inhibitor donepezil on blood levels of the HGFs stem cell factor (SCF), stromal cell-derived factor 1 (SDF-1), granulocyte colony- stimulating factor (G-CSF) and vascular endothelial growth factor (VEGF) in 19 patients with AD and 45 age-matched healthy controls. Donepezil 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 19573265-1 2009 The acetylcholinesterase (AChE) inhibitor donepezil is also a sigma1 receptor agonist. Donepezil 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19286462-0 2009 Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 19286462-2 2009 Donepezil is an AChE inhibitor that is widely prescribed to ameliorate the cognitive impairment of patients with dementia. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 18780301-0 2009 Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer"s disease and relationships with response to treatment with Donepezil and Rivastigmine. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 19262966-2 2009 To demonstrate this approach we examined the cognitive effects of a single acute dose administration of an acetylcholinesterase inhibitor, donepezil, in healthy older adults and in older adults with mild Alzheimer"s disease (AD). Donepezil 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 19388874-3 2009 Donepezil is a drug that been proven to be effective in the treatment of dementia, including Alzheimer"s; it has been used for affective disorders and its mechanism of action is to inhibit the acetylcholinesterase enzyme to increase acetylcholine. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 18554581-6 2008 We also recently analysed whether long-term exposure to the cholinesterase inhibitor (ChE-I) donepezil influences the AChE species found in AD CSF. Donepezil 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 19199870-9 2009 Donepezil increased AChE and BuChE activities by 11.8% and 2.8%, respectively. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 19199870-10 2009 Donepezil caused a 215.2% increase in AChE and 0.4% increase in BuChE protein levels. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 19199870-11 2009 Changes in mean AChE-Readthrough/Synaptic ratios, which might reflect underlying neurodegenerative processes, were 1.4, 0.6, and 0.4 for rivastigmine, donepezil and galantamine, respectively. Donepezil 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19494441-1 2009 Although clinical and experimental research has demonstrated that acetylcholinesterase inhibitors, such as donepezil, are able to enhance cognitive functioning in intact subjects as well as in patients affected by different degrees of dementia, no morphological study has ever analyzed whether donepezil treatment is able to modify neocortical neuronal morphology in the intact brain and in response to cholinergic depletion. Donepezil 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 18821258-0 2008 Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 18821258-1 2008 Pharmacomodulations of previously reported thiaindanones related to donepezil were achieved with the aim to enhance their AChE inhibitory activity. Donepezil 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 18971479-1 2008 Using 24 h of total sleep deprivation to perturb normal cognitive function, we conducted a double-blind, placebo-controlled crossover study to evaluate the effect of the acetylcholinesterase inhibitor, donepezil, on behavioral performance and task-related brain activation in 28 healthy, young, adult volunteers. Donepezil 202-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 18554581-7 2008 The marked increase in CSF-AChE activity in AD patients following long-term treatment with donepezil was not paralleled by a rise in this subset of light variants. Donepezil 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 18818443-1 2008 To determine if donepezil, an acetylcholinesterase (AChE) inhibitor, improved the assimilation of cognitive training by older adults with memory complaints, we gave 168 nondemented, community-dwelling volunteers with memory complaints either 5 mg of donepezil (Aricept) or placebo daily for 6 weeks in a randomized, double-blind, placebo-controlled trial. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 18818443-1 2008 To determine if donepezil, an acetylcholinesterase (AChE) inhibitor, improved the assimilation of cognitive training by older adults with memory complaints, we gave 168 nondemented, community-dwelling volunteers with memory complaints either 5 mg of donepezil (Aricept) or placebo daily for 6 weeks in a randomized, double-blind, placebo-controlled trial. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 18818443-6 2008 Physiological tolerance may occur with chronic donepezil treatment and may increase AChE levels; this may be why short-term studies have shown the benefit of AChE inhibitor use in nondemented participants whereas chronic use has failed to enhance cognition. Donepezil 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 18517184-0 2008 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Donepezil 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 18483726-1 2008 INTRODUCTION: Donepezil, an acetylcholinesterase inhibitor, has been reported to have an effect that improves cerebral blood flow (CBF) alongside its primary effect on memory function. Donepezil 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 18587286-0 2008 Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 18587286-2 2008 Donepezil is a reversible, primarily non-competitive, selective inhibitor of AChE used in patients with Alzheimer"s disease for the improvement of cognitive deficits. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 18587286-3 2008 We hypothesized that prolonged treatment with donepezil could increase AChE mRNA levels and AChE activity in the central nervous system. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 18587286-3 2008 We hypothesized that prolonged treatment with donepezil could increase AChE mRNA levels and AChE activity in the central nervous system. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 18587286-4 2008 METHODS: The levels of AChE mRNA and AChE activity in the brain sections of 6 animals treated for 28 days with donepezil (2 mg/kg s.c.) were visualized by an autoradiographic method of in situ hybridization and by Koelle histochemical staining, respectively, and compared with 6 control animals treated with physiologic saline. Donepezil 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 18587286-4 2008 METHODS: The levels of AChE mRNA and AChE activity in the brain sections of 6 animals treated for 28 days with donepezil (2 mg/kg s.c.) were visualized by an autoradiographic method of in situ hybridization and by Koelle histochemical staining, respectively, and compared with 6 control animals treated with physiologic saline. Donepezil 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 18587286-6 2008 RESULTS: We observed that 28-day treatment with donepezil in comparison to control treatment increased hippocampal AChE mRNA levels and AChE activity. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 18587286-6 2008 RESULTS: We observed that 28-day treatment with donepezil in comparison to control treatment increased hippocampal AChE mRNA levels and AChE activity. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 18587286-8 2008 Further preclinical and clinical data are needed to evaluate the relative impact of the up-regulation of AChE activity on the outcome of prolonged treatment of AD patients with donepezil. Donepezil 177-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18042006-3 2007 The acetylcholinesterase inhibitors used to treat AD patients at present are donepezil, rivastigmine and galantamine. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 18465019-1 2008 A photoenolization reaction is shown to be the key reaction step in the preparation of substituted indan-1-ones as convenient precursors for the synthesis of donepezil, a well-known acetylcholinesterase inhibitor. Donepezil 158-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 18070217-2 2008 * Donepezil hydrochloride exhibits selective inhibition of acetylcholinesterase (AChE) and is widely used for the treatment of AD. Donepezil 2-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 18070217-2 2008 * Donepezil hydrochloride exhibits selective inhibition of acetylcholinesterase (AChE) and is widely used for the treatment of AD. Donepezil 2-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 18070217-4 2008 * There is no method to measure the amount of binding of orally administered donepezil to AChE. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 18070217-7 2008 * This study provides methodology to measure the AChE binding occupancy of orally administered donepezil and provides a new surrogate marker for evaluation and prediction of response to donepezil treatment. Donepezil 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 18070217-7 2008 * This study provides methodology to measure the AChE binding occupancy of orally administered donepezil and provides a new surrogate marker for evaluation and prediction of response to donepezil treatment. Donepezil 186-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 18070217-8 2008 AIMS: The aims of this study were to visualize in vivo binding of donepezil to acetylcholinesterase (AChE) in the brain and to establish a method for measuring the amount of binding of orally administered donepezil. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 18070217-8 2008 AIMS: The aims of this study were to visualize in vivo binding of donepezil to acetylcholinesterase (AChE) in the brain and to establish a method for measuring the amount of binding of orally administered donepezil. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 18070217-12 2008 RESULTS: [(11)C]-donepezil-PET images demonstrated high densities of tracer distribution in AChE-rich brain regions such as the striatum, thalamus, and cerebellum. Donepezil 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 18070217-18 2008 Longitudinal evaluation by this technique enables determination of AChE binding occupancy of orally administered donepezil. Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 17990049-10 2008 A treatment with the AChE-inhibitor donepezil is accompanied with an increase of BDNF serum concentration in AD patients reaching the level of healthy controls. Donepezil 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 17627484-3 2007 Cholinesterase inhibitors has been purported to enhance cognitive function, and previous clinical trials consistently showed that donepezil, a reversible inhibitor of acetylcholinesterase (AChE), led to statistically significant improvements in cognition and patient function. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 17955784-1 2007 The efficacy of the acetylcholinesterase inhibitors donepezil, galantamine and rivastigmine for Alzheimer"s disease is well-documented by a number of studies. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 17627484-3 2007 Cholinesterase inhibitors has been purported to enhance cognitive function, and previous clinical trials consistently showed that donepezil, a reversible inhibitor of acetylcholinesterase (AChE), led to statistically significant improvements in cognition and patient function. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 17724973-2 2007 Presently three AChE inhibitors are approved for the treatment of mild to moderately severe Alzheimer dementia: donepezil, rivastigmine and galantamine. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17484756-1 2007 PURPOSE: To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints. Donepezil 73-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 19300564-5 2007 Some potential effects of donepezil on the AD brain, leading to reduced cortico-hippocampal atrophy, include the following: AChE inhibition, enhancement of cholinergic neurotransmission and putative modulation of other neurotransmitter systems, protection against glutamate-induced excitotoxicity, activation of neurotrophic mechanisms, promotion of non-amyloidodgenic pathways for APP processing, and indirect effects on cerebrovascular function improving brain perfusion. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 17326766-1 2007 We analyzed whether donepezil differently influences acetylcholinesterase (AChE) variants from cerebrospinal fluid (CSF) in patients with Alzheimer"s disease (AD) after long-term treatment. Donepezil 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17326766-4 2007 When patients were re-examined after 12 months treatment with donepezil, there was a remarkable increase in both the G(4) and the lighter species of CSF AChE. Donepezil 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 17326766-5 2007 As compared with placebo, donepezil caused decreases in the percentage of AChE that failed to bind to the lectin concanavalin A and the antibody AE1. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 17124641-3 2006 RESULTS: The present study indicates that in the elderly persons, donepezil, an acetylcholinesterase inhibitor also exerts a marked effect on REM sleep parameters: REM density was increased whereas REM latency was reduced, thus, confirming the findings of our pilot study described earlier. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 17194818-1 2007 OBJECTIVE: The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD). Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 16797936-0 2006 Acetylcholinesterase inhibitor donepezil in the treatment of cognitive deficit in schizophrenia. Donepezil 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16868793-1 2006 OBJECTIVES: To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients. Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16868793-1 2006 OBJECTIVES: To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients. Donepezil 165-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 17005066-1 2007 BACKGROUND: There is general consensus regarding the benefit of acetylcholinesterase inhibitors (e.g. donepezil) in Alzheimer"s disease (AD). Donepezil 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 17272964-1 2007 The objective of this study was to examine the effects of adjunctive treatment with the acetylcholinesterase inhibitor, donepezil, on cognitive deficits and psychopathology in schizophrenic patients treated with the antipsychotic, ziprasidone. Donepezil 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Donepezil 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 309-313 17415417-0 2006 Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 16362770-6 2005 Preliminary results of AChE activity in human blood showed 60-97% and 43-89% of pre-exposed level after one and three days of donepezil administration (5 mg daily), respectively. Donepezil 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 16413803-6 2006 In this work we proposed molecular hybrids of tacrine with donepezil (fusion of these structures), in order to suggest new proposals of AChE inhibitors for future treatment of AD. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 16762377-1 2006 We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer"s disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 16549835-1 2006 PURPOSE: A prospective, open-label phase II study was conducted to determine whether donepezil, a US Food and Drug Administration-approved reversible acetylcholinesterase inhibitor used to treat mild to moderate Alzheimer"s type dementia, improved cognitive functioning, mood, and quality of life (QOL) in irradiated brain tumor patients. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 16549835-10 2006 CONCLUSION: Cognitive functioning, mood, and health-related QOL were significantly improved following a 24-week course of the acetylcholinesterase inhibitor donepezil. Donepezil 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 22500154-2 2006 It is a specific and reversible inhibitor of acetylcholinesterase (AChE); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. Donepezil 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 15920507-0 2005 Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET. Donepezil 29-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 15920507-1 2005 Donepezil hydrochloride is a potent and selective inhibitor for brain acetylcholinesterase (AChE) and is currently used worldwide for the treatment of Alzheimer"s disease. Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 15920507-1 2005 Donepezil hydrochloride is a potent and selective inhibitor for brain acetylcholinesterase (AChE) and is currently used worldwide for the treatment of Alzheimer"s disease. Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 15920507-3 2005 The purpose of this study was to estimate in vivo plasma IC(50) of donepezil in living monkeys by measuring plasma donepezil concentration (LC/MS/MS) and brain AChE activity with positron emission tomography (PET) and N-[(11)C]methylpiperidin-4-yl acetate, which is an acetylcholine analog recently developed by us for quantifying in vivo brain AChE activity. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 15920507-3 2005 The purpose of this study was to estimate in vivo plasma IC(50) of donepezil in living monkeys by measuring plasma donepezil concentration (LC/MS/MS) and brain AChE activity with positron emission tomography (PET) and N-[(11)C]methylpiperidin-4-yl acetate, which is an acetylcholine analog recently developed by us for quantifying in vivo brain AChE activity. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 345-349 15920507-6 2005 The plasma donepezil concentrations 14 min after intravenous injection were proportional to the doses, 17.2+/-2.9 ng/ml (donepezil-1) and 44.0+/-5.0 ng/ml (donepezil-2), and the mean AChE inhibitions in four neocortical regions as evaluated by PET were also dose-dependent, 27% (donepezil-1) and 53% (donepezil-2). Donepezil 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 16901641-4 2006 A single oral dose (3mg) of donepezil, an acetylcholinesterase inhibitor that is commonly used to treat Alzheimer"s disease (AD), improved SAI in DAI patients with wide individual variations that ranged from an increase of 77-18% of test size. Donepezil 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 16600641-1 2006 Acetylcholinesterase inhibitors (AChEI) such as donepezil act in mild Alzheimer"s disease (AD) by increasing cholinergic tone. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16481671-2 2006 Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Donepezil 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 16503777-1 2006 Donepezil, a selective acetylcholinesterase (AChE) inhibitor, has been shown to reduce intraocular pressure (IOP) in ocular normotensive rabbit eyes. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 16503777-1 2006 Donepezil, a selective acetylcholinesterase (AChE) inhibitor, has been shown to reduce intraocular pressure (IOP) in ocular normotensive rabbit eyes. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 16503777-8 2006 These findings show that donepezil, and, possibly, other selective AChE inhibitors, can potentially be used to treat glaucoma. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16601937-3 2006 For one month we studied the effects of donepezil, an acetylcholinesterase inhibitor (5 mg daily), on the cognitive system using P300 auditory event-related potentials (P300) and neuropsychological tests in 10 patients affected by probable VaD according to the NINDS-AIREN criteria. Donepezil 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 16230018-0 2005 Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16137794-0 2005 Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil. Donepezil 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 16137794-1 2005 Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 19595845-0 2005 Reversal of scopolamine-induced deficits with a single dose of donepezil, an acetylcholinesterase inhibitor. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 16485632-0 2005 Potassium channel modulation by acetylcholinesterase inhibitor donepezil. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 16863459-1 2005 Donepezil is a selective acetylcholinesterase inhibitor that is widely prescribed for Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 16192723-2 2005 The objective of this study was to determine if treatment with donepezil, an acetylcholinesterase inhibitor, may provide benefit for VaD patients. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 15716518-3 2005 RESULTS: Analysis of the PET data revealed mean (temporal, parietal, and frontal) cortical donepezil induced AChE inhibition of 19.1% (SD 9.4%) (t = -7.9; p<0.0001). Donepezil 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 15716518-5 2005 Donepezil induced cortical inhibition of AChE activity correlated with changes in the Stroop Color Word interference scores (R(2) = 0.59, p<0.01), but not with primary memory test scores. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 15716518-7 2005 CONCLUSIONS: Donepezil induced inhibition of cortical AChE enzyme activity is modest in patients with mild AD. Donepezil 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 15704966-5 2005 This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15893738-1 2005 Donepezil, a potent acetylcholinesterase (AChE) inhibitor used for the treatment of Alzheimer"s disease (AD), is thought to have a neuroprotective effect in AD patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 15596427-0 2005 Acetylcholinesterase inhibitors for the treatment of Wernicke-Korsakoff syndrome--three further cases show response to donepezil. Donepezil 119-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15596427-1 2005 Three patients diagnosed with Wernicke-Korsakoff syndrome were treated with the acetylcholinesterase inhibitor, donepezil, for periods of 6 to 8 months. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 15496218-15 2004 CONCLUSIONS: The results of this study suggest that patients with AD and mild to moderate hepatic impairment (Child-Pugh grade A or B) can be safely given donepezil 5 mg once daily and that this dose is associated with a nonsignificantly higher AChE inhibition than age-matched volunteers. Donepezil 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-249 15567429-0 2004 Novel neuronal targets for the acetylcholinesterase inhibitor donepezil. Donepezil 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 15567429-1 2004 The effects of the acetylcholinesterase inhibitor donepezil on cell viability and proliferation events have been analysed in SH-SY5Y human neuroblastoma cells. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 22034396-2 2004 Randomized clinical trials comparing the acetylcholinesterase inhibitor donepezil with placebo have shown some symptomatic benefit on (i) cognition in one short-term (6-month) study; and (ii)conversion to dementia in one long-term (3-year) study, but not for the full duration of the study, except in subjects with the apolipoprotein E4 (APOE-4) mutation, in whoom the benefit was sustained throughout the 3 years. Donepezil 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 15341532-4 2004 In these cells, the activity of AChE is significantly decreased after 2 h of donepezil treatment. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Donepezil 269-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Donepezil 269-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 15266045-2 2004 OBJECTIVE: To determine whether an in vivo pharmacokinetic interaction exists between memantine and the acetylcholinesterase (AChE) inhibitor donepezil. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 15266045-7 2004 In addition, AChE inhibition was measured in red blood cells by radiolabeled-enzyme assay following administration of donepezil alone and after a single memantine dose. Donepezil 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 15266045-9 2004 Percent maximum inhibition of AChE activity (mean +/- SD) by donepezil was 77.8 +/- 7.3% and not significantly different upon coadministration of a single dose of memantine (81.1 +/- 5.7%). Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 15118486-4 2004 Patients were assessed for clinical and immunologic features at baseline and after 1 month of treatment with Donepezil, an acetylcholinesterase inhibitor. Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 15333988-4 2004 Donepezil suppressed AChE activity, analyzed by [(11)C]MP4A, in all cortical regions in a dose-dependent manner. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 15333988-5 2004 AChE inhibition by donepezil resulted in a dose-dependent increase in acetylcholine levels in the prefrontal cortex as measured by microdialysis. Donepezil 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 15333988-8 2004 As evaluated by an oculomotor delayed response task, aged monkeys showed impaired working memory performance compared to young monkeys, and the impaired performance was partly improved by the administration of donepezil, due to the facilitation of the cholinergic neuronal system by AChE inhibition by donepezil. Donepezil 210-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 15558381-1 2004 Donepezil, a primarily central acetylcholinesterase inhibitor, could potentiate learning in subjects with stroke by amplifying cholinergic input to the cerebral cortex from the nucleus basalis of Meynert. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Donepezil 230-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 15544502-3 2004 Effectiveness in AChE inhibition and side-effect issues of clinical (tacrine, donepezil, galanthamine and rivastigmine) as well as of novel inhibitors is reviewed here. Donepezil 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 15134572-8 2004 Both [(11)C]MP4A- and [(11)C]MP4P-PET have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with Alzheimer"s disease (AD) but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. Donepezil 196-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 14560059-1 2004 In the present study, the socioeconomic impact of the use of the acetylcholinesterase inhibitor donepezil in patients with mild to moderate Alzheimer"s disease (AD) living in France was examined. Donepezil 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 15132713-4 2004 There is substantial evidence that the cholinesterase inhibitors, including donepezil, galantamine and rivastigmine, decrease acetylcholinesterase activity in a number of brain regions in patients with Alzheimer"s disease. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 12955395-1 2003 The interaction between human serum albumin (HSA) and the acetylcholinesterase inhibitor donepezil, has been studied by means of capillary electrophoresis frontal analysis (CE/FA) and circular dichroism. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 14594748-1 2003 OBJECTIVE: The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer"s disease. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 14964575-4 2004 In contrast, only one acetylcholinesterase inhibitor, donepezil has been proven effective and used for patients with mild or moderate Alzheimer"s disease in Japan. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 14561111-1 2003 Our goal in this study was to determine whether donepezil, an acetylcholinesterase inhibitor, would improve cognitive functioning in 19 subjects with Down syndrome and no dementia. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 15088511-2 2003 The approach to the treatment of Alzheimer"s dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (Aricept) and then rivastigmine (Exelon) and galantamine (Reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. Donepezil 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 13129577-1 2003 Alzheimer"s disease (AD) has been treated with acetylcholinesterase (AChE) inhibitors such as donepezil. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 13129577-1 2003 Alzheimer"s disease (AD) has been treated with acetylcholinesterase (AChE) inhibitors such as donepezil. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 15088511-2 2003 The approach to the treatment of Alzheimer"s dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (Aricept) and then rivastigmine (Exelon) and galantamine (Reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. Donepezil 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 15352644-4 2003 Preliminary studies with donepezil, a centrally acting acetylcholinesterase (AChE) inhibitor approved for use in Alzheimer"s disease, have suggested at least short-term benefit in treating opiate-related sedation. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 15352644-4 2003 Preliminary studies with donepezil, a centrally acting acetylcholinesterase (AChE) inhibitor approved for use in Alzheimer"s disease, have suggested at least short-term benefit in treating opiate-related sedation. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 12604096-2 2003 The long-acting AChE inhibitor donepezil (Aricept) is used to improve memory and other aspects of cognition in AD patients. Donepezil 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 12716251-1 2003 BACKGROUND: In clinical trials, sleep problems have been identified as side effects of donepezil, an acetylcholinesterase (AChE)-inhibiting medication for the treatment of Alzheimer"s disease (AD). Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 12716251-1 2003 BACKGROUND: In clinical trials, sleep problems have been identified as side effects of donepezil, an acetylcholinesterase (AChE)-inhibiting medication for the treatment of Alzheimer"s disease (AD). Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 12604096-2 2003 The long-acting AChE inhibitor donepezil (Aricept) is used to improve memory and other aspects of cognition in AD patients. Donepezil 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 16191240-2 2003 OBJECTIVE: To examine the population characteristics in patients with VaD enrolled in two randomized, double-blind, placebo-controlled, 24-week clinical trials of the efficacy and tolerability of the acetylcholinesterase inhibitor donepezil. Donepezil 231-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 14535624-3 2003 The most selective AChE inhibitors, in decreasing sequence, were in order: TAK-147, donepezil and galantamine. Donepezil 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Donepezil 185-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Donepezil 185-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 12688400-0 2003 Acetylcholinesterase inhibitor (donepezil hydrochloride) reduces heart rate variability. Donepezil 32-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12688400-1 2003 An acetylcholinesterase inhibitor (donepezil hydrochloride) has recently been used for the treatment of senile dementia of Alzheimer type. Donepezil 35-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 14501021-8 2003 However, acetylcholinesterase inhibitors, such as donepezil (Aricept), which potentiate cholinergic neurotransmission, do have a therapeutic role in the management of AD and so the M1 receptor remains a viable therapeutic target. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 14501021-8 2003 However, acetylcholinesterase inhibitors, such as donepezil (Aricept), which potentiate cholinergic neurotransmission, do have a therapeutic role in the management of AD and so the M1 receptor remains a viable therapeutic target. Donepezil 61-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 12454562-1 2002 Donepezil and rivastigmine are acetylcholinesterase (AChE) inhibitors used to improve cholinergic neurotransmission and cognitive function in Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 12454562-6 2002 Treatment with donepezil reduced the AChE activity (k3 values) in the AD brain by 39% in the frontal (p < 0.001, Bonferroni corrected), 29% in the temporal (p = 0.02, corrected) and 28% in the parietal cortex (p = 0.05, corrected). Donepezil 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 12454562-11 2002 Our results indicate that the pooled effects of donepezil and rivastigmine on brain AChE are greater in the frontal cortex compared to the temporal cortex in AD. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 12105320-1 2002 We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 12450245-4 2002 More recent investigations have assessed acetylcholinesterase (AChE) and cholinesterase (ChE) inhibitors such as donepezil, rivastigmine and galantamine. Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 12548360-3 2002 AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 11852291-0 2002 Therapeutic effects of an acetylcholinesterase inhibitor (donepezil) on memory in Wernicke-Korsakoff"s disease. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12139367-3 2002 These events have been associated more with the dual acetylcholinesterase/butyrylcholinesterase (AChE/BuChE) inhibitor rivastigmine than with the AChE-selective inhibitors donepezil and galantamine, probably due to rivastigmine"s higher potency. Donepezil 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 12083745-0 2002 Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor. Donepezil 28-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 255-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 255-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 12094822-2 2002 Donepezil is a specific, reversible inhibitor of AChE, while rivastigmine is a slowly reversible (pseudoirreversible) dual cholinesterase (ChE) inhibitor, with brain-regional specificity for the cerebral cortex and hippocampus. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 12134305-6 2002 Up to now, although with limited success, this improvement has been achieved only with the reversible inhibitors of acetylcholinesterase tacrine, rivastigmine and donepezil, available in the clinic since a few years. Donepezil 163-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 11888054-0 2002 Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection. Donepezil 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 12162759-10 2002 Tacrine and rivastigmine inhibit both enzymes, whereas donepezil and galantamine specifically inhibit AChE. Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 12240787-6 2002 Rivastigmine was well tolerated by our patients when the dose was escalated slowly, including one patient who had previously experienced severe side-effects with the AChE-selective inhibitor donepezil. Donepezil 191-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 11782241-2 2001 OBJECTIVE: To assess the clinical and cognitive effects of adding donepezil, a reversible acetylcholinesterase inhibitor, to the risperidone treatment of a high functioning stable out-patient with schizophrenia. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 11441435-2 2001 OBJECTIVE: The present study aimed to examine the effects of globally increasing cholinergic function with the acetylcholinesterase inhibitor donepezil on inspection time. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 19811047-3 2001 The three new acetylcholinesterase inhibitors licensed to treat Alzheimer"s disease (donepezil, rivastigmine and galantamine) have provided clinicians with a major impetus to their desire to diagnose and treat this lethal disease. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11669506-8 2001 Conventional AChE inhibitors (rivastigmine and donepezil) have maintained ADAS-cog baseline scores for up to 40 weeks in open extension studies, and Mini-Mental State Examination (MMSE) scores for up to 52 weeks in a placebo-controlled study. Donepezil 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 11689088-1 2001 The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11689088-1 2001 The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 11589922-0 2001 Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 11589922-2 2001 This study was designed to assess the effects of 6-12 month treatment with AChEIs donepezil and rivastigmine on cerebrospinal fluid (CSF) AChE and butyrylcholinesterase (BuChE) activity in AD patients. Donepezil 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11589922-4 2001 In AD patients treated with donepezil a significant increase of CFS AChE activity was observed, whereas treatment with rivastigmine induced a significant decrease of AChE activity. Donepezil 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 11226635-3 2001 However, CSF-AChE was significantly increased after treatment of AD patients with AChE inhibitors (donepezil and galantamine). Donepezil 99-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 11369163-1 2001 Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer"s disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 11394735-10 2001 After performing our modelling study the X-ray structure of AChE complexed with donepezil, an inhibitor structurally related to the developed aminopyirdazines, has been made available. Donepezil 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 11255446-1 2001 BACKGROUND: Donepezil hydrochloride is a selective acetylcholinesterase inhibitor approved for the symptomatic treatment of mild to moderately severe Alzheimer disease (AD). Donepezil 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 11171913-0 2001 Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET. Donepezil 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 11171913-1 2001 Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5 mg/d in two patients, 3 mg/d in one patient) using PET and N-[11C]methylpiperidin-4-yl acetate. Donepezil 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11171913-2 2001 Donepezil reduced k(3) values, an index of AChE activity, in the cerebral cortex by 39 +/- 5%. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 11226748-2 2001 The present study indicates that in the elderly, donepezil, an acetylcholinesterase inhibitor, also exerts a marked effect on REM sleep parameters--percentage of REM sleep and REM density were increased whereas REM latency was reduced. Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 11068139-1 2000 In the symptomatic treatment of mild to moderately severe dementia associated with Alzheimer"s disease, donepezil (E2020) has been introduced for the inhibition of acetylcholinesterase activity in the human brain. Donepezil 115-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Donepezil 170-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-5 2000 The benzylpiperidine derivatives donepezil and TAK-147 showed high selectivity for AChE over BuChE. Donepezil 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11343620-4 2000 Donepezil is a second-generation, piperidine-class, selective and reversible acetylcholinesterase inhibitor. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. Donepezil 161-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 11068139-0 2000 Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 11068139-1 2000 In the symptomatic treatment of mild to moderately severe dementia associated with Alzheimer"s disease, donepezil (E2020) has been introduced for the inhibition of acetylcholinesterase activity in the human brain. Donepezil 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-64 11830754-5 2001 Donepezil is highly selective for acetylcholinesterase with a significantly lower affinity for butyrylcholinesterase, which is present predominantly in the periphery. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 11078030-1 2000 Three new cholinesterase inhibitors, donepezil, rivastigmine, and galantamine, all inhibit the enzyme AChE. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 11256231-0 2000 Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Donepezil 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 11256231-1 2000 This study was designed to compare the in vitro inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) of donepezil and some other cholinesterase (ChE) inhibitors which have been developed for the treatment of Alzheimer"s disease. Donepezil 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 11256231-1 2000 This study was designed to compare the in vitro inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) of donepezil and some other cholinesterase (ChE) inhibitors which have been developed for the treatment of Alzheimer"s disease. Donepezil 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 10994012-1 2000 Three patients with REM behavior disorder whose nocturnal symptoms were markedly improved by treatment with the acetylcholinesterase inhibitor donepezil are reported. Donepezil 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 10976649-0 2000 Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Donepezil 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 10976649-1 2000 Based on surrogate assays of peripheral red blood cells, reports state that widely prescribed doses of donepezil hydrochloride provide nearly complete inhibition of cerebral cortical acetylcholinesterase activity in the treatment of Alzheimer"s disease (AD). Donepezil 103-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-203 10984725-5 2000 All patients were prescribed the AChE inhibitor donepezil (5 mg per day). Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 22033801-3 2000 Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 22033801-3 2000 Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 10648652-5 2000 Under equivalent assay conditions, this affinity was 180 times that of huperzine A, 1200 times that of tacrine, and 40 times that of E2020 (donepezil, Aricept), the most selective AChE inhibitor currently approved for therapeutic use. Donepezil 140-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 10648652-5 2000 Under equivalent assay conditions, this affinity was 180 times that of huperzine A, 1200 times that of tacrine, and 40 times that of E2020 (donepezil, Aricept), the most selective AChE inhibitor currently approved for therapeutic use. Donepezil 151-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 11198060-1 2000 Donepezil is an acetylcholinesterase inhibitor indicated for the symptomatic treatment of mild to moderate Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 10641971-2 2000 Tacrine and donepezil are classified as short-acting or reversible agents since binding to acetylcholinesterase enzyme (AChE) is hydrolyzed within minutes. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-118 10641971-2 2000 Tacrine and donepezil are classified as short-acting or reversible agents since binding to acetylcholinesterase enzyme (AChE) is hydrolyzed within minutes. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 11068139-3 2000 This study demonstrates by histochemical means that donepezil exerts a dose-dependent inhibitory effect in vitro on acetylcholinesterase activity. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 11068139-7 2000 In the hippocampus, the axonal acetylcholinesterase reaction end-product was eliminated by 5 x 10(-7)M donepezil. Donepezil 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 11068139-10 2000 These histochemical results provide the first morphological evidence that, under in vitro circumstances, donepezil is not a general acetylcholinesterase inhibitor in the CNS, but rather selectively affects the different brain areas and, within these, the cholinoceptive and cholinergic structures. Donepezil 105-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 11068139-11 2000 The acetylcholinesterase staining in the nerve fibers (innervating the intracerebral blood vessels of the human brain and the extracerebral blood vessels of the rat brain) and at the neuromuscular junction in the diaphragm and gastrocnemius muscle of rat, was also inhibited dose dependently by donepezil. Donepezil 295-304 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 11068139-12 2000 It is concluded that donepezil may be a valuable tool with which to influence both the pre- and the postsynaptic acetylcholinesterase-positive structures in the human and rat central and peripheral nervous systems. Donepezil 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 10622674-8 1999 A number of preliminary studies, whose results are summarized here, have demonstrated that the use of the acetylcholinesterase inhibitors tacrine, metrifonate and donepezil, and the glial cell modulator, propentofylline, results in reductions in the overall costs of care. Donepezil 163-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 11249555-5 1999 Experimentally, donepezil inhibits AChE activity in human erythrocytes and increases extracellular acetylcholine levels in the cerebral cortex and the hippocampus of the rat. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 10549687-1 1999 BACKGROUND: Donepezil is an acetylcholinesterase inhibitor marketed for treatment of memory loss and behavioral deterioration associated with the acetylcholine deficit of Alzheimer"s disease. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 9839758-1 1998 AIM: The aim of this study was to characterize the pharmacokinetic and pharmacodynamic profile of donepezil HCl, a chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following administration of single oral doses. Donepezil 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. Donepezil 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. Donepezil 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 10332937-4 1999 Donepezil HCI represents a new chemical class of AChE inhibitors, the piperidines. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 10447153-6 1999 The results from three pivotal trials investigating the acetylcholinesterase inhibitor, donepezil, are used to demonstrate the way in which these tools are used, how to interpret the data they provide, and to determine their overall value in ascertaining efficacy in clinical practice. Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 10363493-5 1999 RESULTS: Donepezil is a specific, reversible acetylcholinesterase inhibitor of close to 100% absorption and a half-life of 70 h, achieving stable concentrations at approximately 3 weeks. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 10363493-12 1999 CONCLUSIONS: Different studies carried out with the acetylcholinesterase inhibitors donepezil, rivastigmine and metriphonate have been effective in the control of the cognitive symptoms of Alzheimer disease in the initial or moderate phases of the disease. Donepezil 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 9924498-6 1999 Augmentation of cholinergic function through the use of acetylcholinesterase inhibitors with favorable side-effect profiles (e.g., donepezil, possibly metrifonate) can create the potential for improved memory and cognition. Donepezil 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 9839758-1 1998 AIM: The aim of this study was to characterize the pharmacokinetic and pharmacodynamic profile of donepezil HCl, a chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following administration of single oral doses. Donepezil 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 9839758-8 1998 A direct correlation was observed between plasma donepezil concentrations and extent of AChE inhibition. Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 9839758-9 1998 For the 4.0 and 6.0 mg donepezil dose groups, maximal AChE inhibition (Emax) ranged from 33% to 35% and there was significant correlation between AChE inhibition and donepezil plasma concentration (P<0.005). Donepezil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9839758-9 1998 For the 4.0 and 6.0 mg donepezil dose groups, maximal AChE inhibition (Emax) ranged from 33% to 35% and there was significant correlation between AChE inhibition and donepezil plasma concentration (P<0.005). Donepezil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 9839758-11 1998 A direct correlation was also observed between plasma donepezil concentrations and AChE inhibition. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9839759-1 1998 AIM: The aim of this study was to characterize the pharmacokinetics and pharmacodynamics of donepezil HCl, a new, chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following multiple-dose administration. Donepezil 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 9839759-1 1998 AIM: The aim of this study was to characterize the pharmacokinetics and pharmacodynamics of donepezil HCl, a new, chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following multiple-dose administration. Donepezil 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 9839759-11 1998 Inhibition of rbc-AChE was directly correlated with donepezil concentration over a wide concentration range, with the higher concentrations showing the expected hyperbolic relationship. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 9839759-14 1998 A predictable relationship was also observed between plasma donepezil concentrations and rbc-AChE inhibition. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 9475825-6 1998 DATA SYNTHESIS: Donepezil is a cholinesterase inhibitor that is selective and specific for acetylcholinesterase. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 15616667-3 1998 Currently used AChE inhibitors are tacrine, donepezil hydrochloride, rivastigmine and metrifonate. Donepezil 44-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 9771828-4 1998 By contrast, studies with AChE inhibitors--tacrine and donepezil--have been promising. Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 9548205-2 1997 The first such drug to be launched in the U.K. was the acetylcholinesterase inhibitor, donepezil. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 15989517-0 1997 Donepezil (E2020): a new acetylcholinesterase inhibitor. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 15989517-2 1997 Donepezil is an acetylcholinesterase inhibitor under development for the treatment of mild-moderately Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 15989517-3 1997 In vitro, donepezil is about 10 times more potent than tacrine as an inhibitor of acetylcholinesterase. Donepezil 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 15989517-4 1997 Donepezil is 500 - 1000 fold selective for acetylcholinesterase over butyrylcholinesterase. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 9428950-2 1997 Donepezil is a synthetic noncovalent reversible inhibitor of acetylcholinesterase (AChE) for the treatment of mild to moderate dementia associated with Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 9428950-2 1997 Donepezil is a synthetic noncovalent reversible inhibitor of acetylcholinesterase (AChE) for the treatment of mild to moderate dementia associated with Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9428950-3 1997 In contrast to tacrine hydrochloride, the only comparable agent currently approved by FDA, donepezil exhibits a relatively high degree of selectivity for neuronal AChE as opposed to butyrylcholinesterase. Donepezil 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Donepezil 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). Donepezil 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). Donepezil 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9108896-1 1997 Donepezil is a specific and potent acetylcholinesterase inhibitor according to in vitro data. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 9108896-3 1997 In vivo, donepezil inhibited acetylcholinesterase activity in human erythrocytes and increased extracellular acetylcholine levels in the cerebral cortex and hippocampus of the rat. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 8535413-0 1995 Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020). Donepezil 59-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 8915035-9 1996 In addition, a statistically significant correlation between plasma concentrations of donepezil and AChE inhibition was demonstrated. Donepezil 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 25539902-5 2015 Donepezil is a high-affinity ligand for acetylcholinesterase-the enzyme that catabolizes acetylcholine in cholinergic synapses. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 7738604-0 1994 Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program. Donepezil 34-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7738604-3 1994 Here we present a prediction of the binding sites of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine (E2020) in AChE by the same method. Donepezil 53-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 7738604-3 1994 Here we present a prediction of the binding sites of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine (E2020) in AChE by the same method. Donepezil 114-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 33809771-3 2021 Herein, a series of hybrid compounds are reported which were designed and developed by combining an aryl-sulfonamide function with a benzyl-piperidine moiety, the pharmacophore of donepezil (a current anti-AD acetylcholinesterase AChE inhibitor drug) or its benzyl-piperazine analogue. Donepezil 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 34755546-6 2021 The selectivity for AChE over BuChE of compound 8e was approximately 17-times higher than donepezil and 26-times higher than galantamine. Donepezil 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 34931332-2 2022 Moreover, like donepezil, it was thought that the enzyme AChE would provide pi-pi interactions with the peripheral anionic side in this structure. Donepezil 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 34893996-7 2022 The reference drug donepezil (IC50 = 0.021 microM) also displayed significant inhibition of AChE. Donepezil 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 33478277-2 2021 In the present study, we used three docking-based virtual screening approaches to screen both ZINC15 and MolPort databases for synthetic analogs of physostigmine and donepezil, two highly potent AChE inhibitors. Donepezil 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 34198150-6 2021 It was identified as a highly potent AChE inhibitor and was found superior to donepezil, the first-line drug for the treatment of AD. Donepezil 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 34337258-3 2021 Compounds 13, 17, 18, 21, 23, 31, and 33 displayed moderate activity with 25-50% relative potency compared to the known potent AChE inhibitor donepezil. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 34714861-10 2021 A significant difference in enzyme activity of the catalytic site mutants was observed as compared to the wildtype, and subsequent AChE activity showed that esterase activity of PON2 is responsible for the hydrolysis of DHC and PB. Donepezil 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Donepezil 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Donepezil 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 34363318-0 2021 Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil. Donepezil 119-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34363318-1 2021 The fractal dimension (D) of the active site of hAChE in the unliganded state and as part of complexes with hyperzine A, galantamine, and donepezil is calculated using molecular interatomic-distance histograms. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-222 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 34337258-4 2021 Molecular docking studies of the active compounds docked within the active site cavity of AChE showed a binding orientation similar to that of donepezil, with good predicted binding affinities. Donepezil 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 34911424-4 2021 Similar positive although variable results have also been found in volumetric measurements of the cortex and whole brain in patients with mild cognitive impairment as well as more advanced AD stages after treatments with all three currently available acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, and galantamine). Donepezil 291-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 251-271 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34911424-4 2021 Similar positive although variable results have also been found in volumetric measurements of the cortex and whole brain in patients with mild cognitive impairment as well as more advanced AD stages after treatments with all three currently available acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, and galantamine). Donepezil 291-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 33540879-6 2021 Dual-drug combinations of berberine and tacrine (BerTac), berberine and galantamine (BerGal), and tacrine and donepezil (TacDon) all produced synergistic outcomes for AChE inhibition. Donepezil 110-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 34078793-1 2021 Donepezil, the most widely used drug for the treatment of Alzheimer"s disease (AD), is an acetylcholinesterase (AChE) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 34078793-1 2021 Donepezil, the most widely used drug for the treatment of Alzheimer"s disease (AD), is an acetylcholinesterase (AChE) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 35462163-8 2022 Several piperidine derivatives (in particular compound 10) showed interesting profiles as multi-target directed agents, while the lead piperazine derivative 12 (SON38) was found to be a more potent and selective AChE inhibitor (IC50 = 0.8 nM) than donepezil, besides being able to bind bivalent copper cations (pCu = 7.9 at physiological pH). Donepezil 248-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 35462270-11 2022 The binding energies of the complexes, title compound-AChE, donepezil-AChE, and galantamine-AChE, were calculated to be -7.80, -10.41, and -8.16 kcal/mol, respectively. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 35462270-11 2022 The binding energies of the complexes, title compound-AChE, donepezil-AChE, and galantamine-AChE, were calculated to be -7.80, -10.41, and -8.16 kcal/mol, respectively. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 35408519-6 2022 The reference drug donepezil (IC50 = 0.021 microM) also showed significant inhibition against AChE. Donepezil 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Donepezil 249-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Donepezil 249-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35221376-1 2022 In an effort to develop new therapeutic agents to treat Alzheimer"s disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biologically evaluated for their inhibitory activity against electric eel acetylcholinesterase (AChE) enzyme. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-285 35221376-2 2022 In vitro studies revealed that the phenyl moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of electric eel AChE. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 35595404-2 2022 Current pharmacological treatment includes acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine; however, only one-third of patients respond to treatment. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 33915501-4 2021 The Food and Drug Administration (FDA), has approved acetylcholinesterase (AChE) inhibitors (donepezil, galantamine, tacrine and rivastigmine) and glutamate receptor antagonist (memantine) for the treatment of AD. Donepezil 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 33844597-3 2021 AChE inhibitors can have therapeutic applications (e.g., tacrine and donepezil) or neurotoxic consequences (e.g., insecticides and nerve agents). Donepezil 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33230575-1 2021 Acetylcholinesterase inhibitors such as donepezil delay the progression of Alzheimer"s dementia by increasing acetylcholine concentrations in the central nervous system. Donepezil 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33416315-2 2021 Despite the tremendous research efforts in the last decade, only four supportive or palliative drugs, namely, acetylcholinesterase (AChE) inhibitors donepezil, galantamine, and rivastigmine and the glutamate NMDA receptor antagonist memantine, are currently available. Donepezil 149-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 33416315-2 2021 Despite the tremendous research efforts in the last decade, only four supportive or palliative drugs, namely, acetylcholinesterase (AChE) inhibitors donepezil, galantamine, and rivastigmine and the glutamate NMDA receptor antagonist memantine, are currently available. Donepezil 149-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 33540879-8 2021 Donepezil and galantamine (DonGal) was synergistic for human AChE but antagonistic for tcAChE. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33054569-3 2022 While acetylcholinesterase (AChE) inhibitors such as donepezil and galantamine are leading drugs in the symptomatic treatment of AD, new AChE inhibitors continue to be explored for improved potency and selectivity. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 33100197-2 2021 The most worldwide famous acetylcholinesterase inhibitor (AChEIs) donepezil for its dominant role in Alzheimer"s disease (AD) has also attracted the eyes of many pharmaceuticals regarding its promising pharmacological potencies such as neuroprotective, muscle relaxant, and sleep. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 32942070-5 2020 Herein, we developed an energy-optimized e-pharmacophore hypothesis AHHPRR from AChE-donepezil complex and screened a set of 15 scaffolds that were designed imaginarily. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 32955256-2 2020 We report herein a new donepezil-like natural compound derivative (D1) as a convincing AChE inhibitor. Donepezil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 32955256-6 2020 While most of the noncholinergic functions of donepezil associated with the PAS of AChE were gradually lost at higher concentrations, D1 was more functional at similar doses. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 33375412-3 2020 Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33375412-3 2020 Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). Donepezil 99-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33058916-7 2020 Donepezil, an acetylcholinesterase inhibitor, improves cognition and global function in patients with Alzheimer"s and Vascular dementia via modulation of acetylcholine receptors and downstream inflammatory response. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 33327436-10 2020 The drug combination of fangchinoline-huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 33054569-9 2022 Another five compounds showed stronger docking scores against AChE than the clinically used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE. Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 32454110-0 2020 The inefficacy of donepezil on glycated-AChE inhibition: Binding affinity, complex stability and mechanism. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 32454110-2 2020 In the present study, the inhibitory effect of DPZ on non-enzymatic glycated-AChE (GLY-AChE) was studied by different experimental and simulation techniques. Donepezil 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32454110-2 2020 In the present study, the inhibitory effect of DPZ on non-enzymatic glycated-AChE (GLY-AChE) was studied by different experimental and simulation techniques. Donepezil 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Donepezil 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Donepezil 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Donepezil 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 32454110-7 2020 The stability assessment showed that AChE-DPZ complex is more stable than the glycated complex. Donepezil 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 33061904-1 2020 Acetylcholinesterase inhibitors (AChEIs) including donepezil (DNP) are considered to be the most promising therapeutic possibilities of Alzheimer"s disease (AD). Donepezil 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33061904-1 2020 Acetylcholinesterase inhibitors (AChEIs) including donepezil (DNP) are considered to be the most promising therapeutic possibilities of Alzheimer"s disease (AD). Donepezil 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32874532-1 2020 Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer"s disease (AD). Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 32752941-4 2021 Remarkably, amongst the series, the compound 2 was identified as the most active inhibitor of both AChE (IC50 = 0.05 +- 0.01 muM) and BChE (IC50 = 0.09 +- 0.02 muM) relative to the standard Donepezil (IC50 = 0.09 +- 0.01 for AChE and 0.13 +- 0.04 muM for BChE). Donepezil 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 33042734-4 2020 Here, clioquinol (metal-ion chelating agent) and donepezil (acetylcholinesterase (AChE) inhibitor) co-encapsulated human serum albumin (HSA) nanoparticles (dcHGT NPs) are designed, which are modified with transcriptional activator protein (TAT) and monosialotetrahexosylganglioside (GM1). Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 33042734-4 2020 Here, clioquinol (metal-ion chelating agent) and donepezil (acetylcholinesterase (AChE) inhibitor) co-encapsulated human serum albumin (HSA) nanoparticles (dcHGT NPs) are designed, which are modified with transcriptional activator protein (TAT) and monosialotetrahexosylganglioside (GM1). Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 32096991-9 2020 All together, our findings support a physiologically-relevant mechanism of AChE inhibition by donepezil involving multistable interactions modes at the molecular origin of inhibitor"s activity. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 32096991-0 2020 Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 32096991-1 2020 Donepezil is a second generation acetylcholinesterase (AChE) inhibitor for treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 32096991-1 2020 Donepezil is a second generation acetylcholinesterase (AChE) inhibitor for treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 32096991-3 2020 In vitro data support that donepezil is a reversible, mixed competitive and non-competitive inhibitor of AChE. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32356584-3 2020 Especially compounds 6c and 6e were found to be the most potent with relative AChE inhibition percentages of 87% in comparison to donepezil. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32356584-4 2020 The docking studies with AChE showed similar interactions between Donepezil and these four derivatives. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 31444085-7 2019 Therefore, the structure-active-relationship of 2-acetylphenol-donepezil hybrids could encourage the development of multifunction agents with selective AChE inhibition or selective MAO-B inhibition for the treatment of Alzheimer"s disease. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32414155-4 2020 The current AChE inhibitors (donepezil, rivastigmine, and galantamine) have short-acting mechanisms of action that result in dose-limiting toxicity and inadequate efficacy. Donepezil 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 32174113-2 2020 Donepezil is a well-known acetylcholinesterase inhibitor with its primary application being the treatment of Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 32098407-2 2020 Among the DNP-BIM hybrids studied herein, the structural isomerization did not significantly improve the biological properties, while some substitutions, namely fluorine atom in each moiety or the methoxy group in the benzyl ring, evidenced higher cholinergic AChE activity. Donepezil 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-264 32986667-3 2020 OBJECTIVE: The aim of the current study was to evaluate the potential of two tacrine-donepezil hybrid molecules (TA8Amino and TAHB3), which are AChE inhibitors, to induce neurodifferentiation and neuritogenesis in SH-SY5Y cells. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 32184102-9 2020 Knockdown of ACHE was achieved by lipofectamine-mediated siRNA transfection and pharmaceutical suppression of ACHE was manipulated by donepezil. Donepezil 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 33488178-2 2020 Food and Drug Administration (FDA) approved drugs donepezil, rivastigmine, tacrine and galantamine are AChE inhibitors and in the treatment of Alzheimer"s disease (AD) these drugs are currently prescribed. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 11-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 11-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 31878304-2 2019 Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-beta (Abeta) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 30918344-5 2019 Here we report that donepezil, an acetylcholinesterase inhibitor (AChEI) developed for the treatment of Alzheimer"s disease (AD), significantly promotes OPC to OL differentiation. Donepezil 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 215-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 215-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). Donepezil 274-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 31173012-1 2019 Donepezil, an acetylcholinesterase inhibitor, is an approved drug for the symptomatic treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 31173012-2 2019 The mechanistic pathway for the inhibition mechanism of acetylcholinesterase (AChE) by donepezil is not well explored. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 31173012-2 2019 The mechanistic pathway for the inhibition mechanism of acetylcholinesterase (AChE) by donepezil is not well explored. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-240 31173012-4 2019 This study explored the orientation of the donepezil drug molecule inside the gorge of AChE. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 31173012-5 2019 The 1D free energy surface obtained from WTMtD simulation studies reveals that the orientation of donepezil in the crystal donepezil (-87.25 kJ mol-1) is energetically more favored than the other orientation of donepezil (-74.74 kJ mol-1) for inhibition of AChE. Donepezil 98-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 31173012-5 2019 The 1D free energy surface obtained from WTMtD simulation studies reveals that the orientation of donepezil in the crystal donepezil (-87.25 kJ mol-1) is energetically more favored than the other orientation of donepezil (-74.74 kJ mol-1) for inhibition of AChE. Donepezil 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 31173012-5 2019 The 1D free energy surface obtained from WTMtD simulation studies reveals that the orientation of donepezil in the crystal donepezil (-87.25 kJ mol-1) is energetically more favored than the other orientation of donepezil (-74.74 kJ mol-1) for inhibition of AChE. Donepezil 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 31162119-4 2019 Acetylcholinesterase inhibitors (donepezil or rivastigmine) were studied in several double-blind placebo-controlled studies. Donepezil 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31173012-7 2019 The WTMtD simulation performed with the crystal structure of donepezil bound hAChE gives the conformation of donepezil at Basin-I as similar to the conformation of donepezil observed in the crystal structure (). Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-82 31173012-7 2019 The WTMtD simulation performed with the crystal structure of donepezil bound hAChE gives the conformation of donepezil at Basin-I as similar to the conformation of donepezil observed in the crystal structure (). Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-82 31173012-7 2019 The WTMtD simulation performed with the crystal structure of donepezil bound hAChE gives the conformation of donepezil at Basin-I as similar to the conformation of donepezil observed in the crystal structure (). Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-82 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-200 30904408-3 2019 The main objective of this work was to study the effect of donepezil on human erythrocytes as AChE is present in its membrane. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 30904408-9 2019 This effect was explained by the incorporation of donepezil molecules into the erythrocyte membrane and interactions with AChE. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 30765424-3 2019 Acetylcholinesterase inhibitors, such as donepezil, can cause bleeding in patients, but the underlying mechanisms are not well understood. Donepezil 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30765424-8 2019 Furthermore, drugs inhibiting acetylcholinesterase, such as donepezil, also inhibit platelet activation, suggesting that platelets release acetylcholine. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). Donepezil 274-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30785927-0 2019 Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer"s disease. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30639387-3 2019 Inspired from "HDL bionics", we proposed biologically reassembled nanodrugs, donepezil-loaded apolipoprotein A-I-reconstituted HDL (rHDL/Do) that concurrently executed dual-missions of Abeta-targeting clearance and acetylcholinesterase (AChE) inhibition in AD therapy. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 30673880-10 2019 There is a consensus on benefit of initiating any acetylcholinesterase inhibitor (ACHI: donepezil, rivastigmine, and galantamine) as a first line of treatment for psychosis in AD, as it may reduce and/or avoid the need for the use antipsychotics. Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 30378536-1 2019 OBJECTIVE: Donepezil is an acetylcholinesterase inhibitor (AChI) that improves cognitive function in Alzheimer"s disease (AD) patients. Donepezil 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 30819078-4 2019 Donepezil is one of the currently approved drugs for AD therapy acting as an acetylcholinesterase inhibitor. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 30372021-4 2019 This review is focused on donepezil and covers the background, synthetic routes, structure-activity relationships, binding interactions with acetylcholinesterase, pharmacokinetics and metabolism, efficacy, adverse effects, and historical importance of this leading therapeutic in the treatment of Alzheimer"s disease and true Classic in Chemical Neuroscience. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 31334039-4 2019 Results: The investigated systems exhibited strong inhibition activities against AChE, with CyC (IC50= 85.12 +- 6.70 nM) acting as better inhibitor than AMC (IC50 = 103.09 +- 11.90 nM) and both having IC50 values in the range of FDA approved cholinergic drug Donepezil (IC50 = 74.13 +- 8.30 nM). Donepezil 259-268 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 29768996-5 2019 Donepezil was able to ameliorate the symptoms related to AD mainly via AChE, but also through reduction of beta-amyloid burden. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 31315114-2 2019 To further optimize treatment, acetylcholinesterase inhibitors such as donepezil and galantamine have gained increased interest, though with conflicting results. Donepezil 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 30411689-5 2019 METHODS: The objective of this work is to identify new substances that have spatial structural similarity with donepezil, an efficient commercial drug used for the treatment of Alzheimer"s disease, and to evaluate the capacity of inhibition of these new substances against the enzyme acetylcholinesterase. Donepezil 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 284-304 30343499-3 2018 Drugs, such as tacrine, rivastigmine, donepezil, and galantamine are known as acetylcholinesterase inhibitors. Donepezil 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 30470757-4 2018 The synthetic utility of this method is demonstrated by late-stage difluoroalkylation of donepezil, a well-known acetylcholinesterase inhibitor used to treat the Alzheimer"s disease. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 30290248-3 2018 However, the inhibition constant (Ki) was found to be 36.0 +- 0.4 muM with IC50 value of 20.0 +- 1.0 muM, whereas donepezil showed 3.2 +- 0.3 muM with the IC50 value of 0.12 +- 0.04 muM for human acetylcholinesterase. Donepezil 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-216 29804239-6 2018 Donepezil (DON), a centrally acting, reversible and non-competitive acetylcholinesterase (AChE) inhibitor, approved for use in Alzheimer"s disease (AD), may also attenuate EtOH-induced cognitive impairment. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29966870-0 2018 Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 29966870-3 2018 Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site. Donepezil 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-60 30311614-3 2018 Some compounds prepared showed AChE inhibitory potential in the low micromolar range similar to that obtained with donepezil, a commercially available cholinesterase inhibitor. Donepezil 115-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 29804239-6 2018 Donepezil (DON), a centrally acting, reversible and non-competitive acetylcholinesterase (AChE) inhibitor, approved for use in Alzheimer"s disease (AD), may also attenuate EtOH-induced cognitive impairment. Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29804239-7 2018 Cognitive effects of DON might be due to an anti-apoptotic activity as some AChE inhibitors have been shown to have this property. Donepezil 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 29655025-7 2018 Molecular docking studies indicated that the binding mode of the compound 5f share common characteristics with the galantamine/donepezil-AChE complexes. Donepezil 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 30017317-0 2018 Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors. Donepezil 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 30568757-5 2018 Molecules 5g and 5a disaggregated AChE-induced (58.26%, 47.36%) Abeta aggregation more than two fold more than the standard drug-donepezil (23.66%) and inhibited Cu2+-induced Abeta aggregation. Donepezil 129-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-246 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 248-252 29679445-5 2018 The strategy is to obtain an effective mimetic of donepezil, which is acetylcholinesterase inhibitor. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 29777723-0 2018 Effect of acetylcholinesterase inhibitors donepezil and rivastigmine on the activity and expression of cyclooxygenases in a model of the inflammatory action of fluoride on macrophages obtained from THP-1 monocytes. Donepezil 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Donepezil 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Donepezil 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 29635172-2 2018 In the present study, a surface plasmon resonance (SPR)-based assay was developed and employed to investigate interactions between human recombinant AChE (hAChE) and four known ligands: galantamine, tacrine, donepezil and edrophonium. Donepezil 208-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 29706984-2 2018 While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (AChE inhibitor) to rivastigmine (AChE and butyrylcholinesterase [BuChE] inhibitor) improves appetite. Donepezil 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 29299992-1 2018 BACKGROUND: Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer"s disease (AD). Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29299992-1 2018 BACKGROUND: Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer"s disease (AD). Donepezil 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 375-379 29421570-5 2018 In addition, compound 4c showed a similar binding mode to donepezil in both acetylated and free forms of AChE enzyme in molecular docking studies and did not show relevant toxic effects on in vitro and in vivo assays, with good predicted ADME parameters in silico. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29463072-0 2018 The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Donepezil 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 29463072-1 2018 A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 29463072-1 2018 A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29463072-2 2018 This study aimed to characterize the effective concentration of donepezil on AChE inhibition and impaired learning and memory in rodents. Donepezil 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 29463072-5 2018 Plasma AChE activity was negatively correlated with plasma donepezil concentration. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-11 29463072-9 2018 In conclusion, our findings suggest that the AChE inhibitory activity and pharmacological effects of donepezil can be predicted by the concentration of donepezil. Donepezil 152-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 29067789-1 2018 The objective of this study was to elucidate the pharmacokinetics and metabolite formation of newly developed non-selective AChE/BChE 7-MEOTA-donepezil-like inhibitors for potential therapeutic use in Alzheimer"s disease (AD) patients. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 29706984-2 2018 While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (AChE inhibitor) to rivastigmine (AChE and butyrylcholinesterase [BuChE] inhibitor) improves appetite. Donepezil 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 29182921-2 2018 Their design envisaged mainly to mimic the donepezil drug, a marketed inhibitor of acetylcholinesterase (AChE), and to endow the conjugate molecules with extra-properties such as metal chelation, radical scavenging and inhibition of amyloid peptide (Abeta) aggregation. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 29324339-0 2018 Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship. Donepezil 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 28974110-3 2018 Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). Donepezil 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 28974110-3 2018 Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). Donepezil 85-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 29182921-2 2018 Their design envisaged mainly to mimic the donepezil drug, a marketed inhibitor of acetylcholinesterase (AChE), and to endow the conjugate molecules with extra-properties such as metal chelation, radical scavenging and inhibition of amyloid peptide (Abeta) aggregation. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29182921-5 2018 The closest similarity with donepezil, in terms of AChE inhibitory activity, was obtained for the O-benzyl-hydroxypyridinone hybrids containing a 2-methylene linker, although still less active than the drug. Donepezil 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 28667874-3 2017 Among the medicinally important indanones, the most significant drug probably is donepezil (IV), an acetylcholinesterase (AChE) inhibitor, which has been approved by the US Food and Drug Administration for the treatment of Alzheimer"s disease (AD). Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 29737870-2 2018 We hypothesized that donepezil, an acetylcholinesterase inhibitor, would enhance cognitive recovery beyond that of usual care in an acute rehabilitation facility. Donepezil 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 29852870-0 2018 Acetylcholinesterase Inhibitor Donepezil Effects on Plasma beta-Hydroxybutyrate Levels in the Treatment of Alzheimer"s Disease. Donepezil 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29852870-2 2018 Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory effect, to act through other non-cholinergic mechanisms such as affecting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma coactivator (PGC1alpha). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 29852870-2 2018 Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory effect, to act through other non-cholinergic mechanisms such as affecting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma coactivator (PGC1alpha). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 28940630-6 2017 Molecular dynamics studies of compound 6d showed that the interaction with the peripheral binding site of AChE was similar to donepezil, which may explain its low IC50 (0.64 muM). Donepezil 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 29099058-0 2017 Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 29099058-3 2017 Donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 28841514-4 2017 Herein, we report the development of a novel series of thiosemicarbazones derived from 1-benzylpiperidine, a pharmacophore within the acetylcholinesterase inhibitor, Donepezil. Donepezil 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 28667874-3 2017 Among the medicinally important indanones, the most significant drug probably is donepezil (IV), an acetylcholinesterase (AChE) inhibitor, which has been approved by the US Food and Drug Administration for the treatment of Alzheimer"s disease (AD). Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 28104598-1 2017 We report a case of Pisa syndrome (PS) due to the acetylcholinesterase inhibitor donepezil which may have been precipitated by pharmacokinetic interactions with commonly used medications. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 28711758-1 2017 In this report we assessed by docking and molecular dynamics the binding mechanisms of three FDA-approved Alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (AChE): donepezil, galantamine and rivastigmine. Donepezil 177-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 28922421-2 2017 Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 28922421-2 2017 Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. Donepezil 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 28668178-1 2017 Donepezil is the most commonly prescribed acetylcholinesterase inhibitor for the treatment of Alzheimer"s disease, an ailment that affects millions of older adult patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 28751142-5 2017 Biological results revealed that some of these compounds display good biological activities against AChE with IC50 values about 44.67-169.80nM (donepezil IC50 50.12nM). Donepezil 144-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 28427041-0 2017 The efficacy of donepezil administration on acetylcholinesterase activity and altered redox homeostasis in Alzheimer"s disease. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 28427041-6 2017 The AChE activity was significantly higher both in donepezil treated and untreated groups when compared with the control group. Donepezil 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 28894751-1 2017 The study was designed to test the hypothesis that the inhibition of acetylcholinesterase (AChE) activity at the periphery by Neostigmine (0.5 mg/animal) will be sufficient to prevent inflammatory dependent suppression of the gonadotropin-releasing hormone (GnRH)/luteinising hormone (LH) secretion in ewes in the follicular phase of the estrous cycle, and this effect will be comparable with the systemic AChE inhibitor, Donepezil (2.5 mg/animal). Donepezil 422-431 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 27785538-11 2017 PCR analyses suggested that the 11C-donepezil signal in inflammatory cells is derived from both acetylcholinesterase and sigma-1 receptors. Donepezil 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 28840133-0 2017 Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A 11C-donepezil PET Study. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 28840133-2 2017 Therefore, we aimed to examine the whole-body distribution of donepezil (DNP) as an acetylcholinesterase inhibitor by means of 11C-DNP PET imaging, combined with the oral administration of pharmacological doses of DNP. Donepezil 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 28840133-2 2017 Therefore, we aimed to examine the whole-body distribution of donepezil (DNP) as an acetylcholinesterase inhibitor by means of 11C-DNP PET imaging, combined with the oral administration of pharmacological doses of DNP. Donepezil 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 28243607-2 2017 In this study, we aimed to demonstrate the role of sildenafil (an antagonist of phosphodiesterase type 5 (PDE-5)) and donepezil (a specific and reversible inhibitor of acetylcholinesterase (Ach)) in increasing ischemia-induced angiogenesis. Donepezil 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 27871793-2 2017 The inhibitory profiles of the compounds have been compared with standard AChE inhibitor donepezil. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 28403780-7 2017 Docking study was utilized to understand the binding mode of compound 2j in comparision with donepezil on AChE. Donepezil 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 28133526-2 2017 Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. Donepezil 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 27911294-1 2017 BACKGROUND: Donepezil is an acetylcholinesterase inhibitor frequently prescribed for the treatment of mild cognitive impairment (MCI) though not approved by the Food and Drug Administration for this indication. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 28133526-2 2017 Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. Donepezil 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 28133526-9 2017 Moreover, a similar binding mode was observed in silico for all ligands in superimposition state with donepezil into the active site of acetylcholinesterase. Donepezil 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 28066242-1 2016 Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer"s disease patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 27914299-7 2017 In the second section, the effect of fluorination on the drug enzyme interactions was evaluated by using two effective methods Based on the molecular docking and density functional theory (DFT) calculations fluorine substitution influenced the Donepezil Acetylcholinesterase interactions. Donepezil 244-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-274 27718143-11 2017 Based on these data, it is plausible to predict that donepezil might produce a stronger AChE inhibition in the brain at 24 h compared with 12 h following the administration. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 27664791-3 2017 Previously, using oligodendrocyte progenitor cells, we have shown that donepezil, which is an acetylcholinesterase inhibitor developed for the treatment of Alzheimer"s disease, stimulates myelin gene expression and oligodendrocyte differentiation. Donepezil 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 27783974-1 2016 Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 27783974-1 2016 Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 27392137-0 2016 Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 27442715-4 2016 Prior studies have shown that donepezil, an acetylcholinesterase inhibitor, might improve OSA, but the mechanism is unknown. Donepezil 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 26022447-10 2016 Of these five patients, one patient took the acetylcholinesterase inhibitor drug donepezil. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 27392137-3 2016 Although donepezil is approved for use in patients and selective for inhibiting acetylcholinesterase over BuChE, no studies have reported cocaine bioavailability in human subjects receiving donepezil. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 26738844-3 2016 The goal of this pilot study was to examine the efficacy of donepezil, an acetylcholinesterase inhibitor used to treat Alzheimer"s disease, in improving cognitive functions in brain tumor patients previously treated with RT + chemotherapy or chemotherapy alone. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 27083471-8 2016 Compounds containing N-methyl-4-piperidone linker, showed high acetylcholinesterase and self-induced Abeta aggregation inhibitory activities as compared to reference drug donepezil. Donepezil 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 28635795-3 2016 To overcome the cholinergic insufficiency, acetylcholinesterase inhibitors (rivastigmine, donepezil and galantamine) are primarily used. Donepezil 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 27190595-0 2016 Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 26861273-5 2016 In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 27158324-6 2016 The AChE inhibitor, donepezil, is proven to strengthen cognitive functions and appears effective in treating moderate to severe AD patients. Donepezil 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 26143664-6 2016 Initiation of donepezil, an acetylcholinesterase inhibitor, resulted in the disappearance of these symptoms and total recovery of the patient to his previous psychosocial levels. Donepezil 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 26166237-7 2015 Donepezil hydrochloride, a reversible acetylcholinesterase inhibitor, was orally administered 5 mg/d for 6 weeks after the initial evaluation and was increased to 10 mg/d for the following 6 weeks. Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 25998147-2 2015 National guidelines recommend treatment with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) or the N-Methyl-D-Aspartate antagonist (memantine) to reduce cognitive symptoms. Donepezil 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 25690270-5 2015 Donepezil is an acetylcholinesterase inhibitor approved for use across the full spectrum of mild, moderate, and severe AD. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 25690270-7 2015 The rationale for the higher dose formulation was the expected increase in acetylcholinesterase inhibition given the dose-response relationship of donepezil, with the benefits of the higher dose being most apparent in patients with more advanced AD. Donepezil 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 25681712-4 2015 The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. Donepezil 176-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 25681712-4 2015 The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. Donepezil 176-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 25792802-1 2015 BACKGROUND: Donepezil is an acetylcholinesterase inhibitor indicated for Alzheimer"s disease. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 26455564-4 2015 The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. Donepezil 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 25484499-1 2014 Donepezil, an acetylcholinesterase inhibitor, is approved for the treatment of mild to moderate dementia secondary to Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 24774720-5 2014 We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 25036795-3 2014 The anti-cholinesterase activity evaluation of synthesized compounds revealed that most of them had very potent inhibitory activity against AChE, superior to standard drug donepezil. Donepezil 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 25036795-4 2014 Particularly, 2-chlorobenzyl derivative 3c was the most potent compound against AChE with IC50 value of 0.44 nM, being 32-fold more potent than donepezil. Donepezil 144-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 24785550-1 2014 INTRODUCTION: Donepezil is a highly selective acetylcholinesterase inhibitor and one of the only four drugs currently approved for treatment of Alzheimer"s dementia. Donepezil 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 23711227-1 2013 The main purpose of this study was to evaluate whether donepezil, acetylcholinesterase inhibitor, shown to play a protective role through inhibiting glycogen synthesis kinase-3beta (GSK-3beta) activity, could also exert neuroprotective effects by stimulating protein phosphatase 2A (PP2A) activity in the amyloid-beta (Abeta)42-induced neuronal toxicity model of Alzheimer"s disease. Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 24261316-1 2014 BACKGROUND: The first-line medication gabapentin and the acetylcholinesterase inhibitor donepezil represent a new promising combination to improve treatment outcomes for patients with severe neuropathic pain. Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 24251806-5 2014 Besides its high potency, donepezil also exhibited high selectivity for AChE and a very low toxicity. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 23526889-1 2013 The recognition and association of donepezil with acetylcholinesterase (AChE) has been extensively studied in the past several decades because of the former"s use as a palliative treatment for mild Alzheimer disease. Donepezil 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 23526889-1 2013 The recognition and association of donepezil with acetylcholinesterase (AChE) has been extensively studied in the past several decades because of the former"s use as a palliative treatment for mild Alzheimer disease. Donepezil 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 23526889-2 2013 Herein we examine the conformational properties of donepezil and we re-examine the donepezil-AChE crystal structure using combined quantum mechanical/molecular mechanical (QM/MM) X-ray refinement tools. Donepezil 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 23526889-4 2013 The donepezil-AChE complex (PDB 1EVE) was also re-refined through a parallel QM/MM X-ray refinement approach based on an in-house ab initio code QUICK, which uses the message passing interface (MPI) in a distributed SCF algorithm to accelerate the calculation via parallelization. Donepezil 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 23526889-5 2013 In the QM/MM re-refined donepezil structure, coordinate errors that previously existed in the PDB deposited geometry were improved leading to an improvement of the modeling of the interaction between donepezil and the aromatic side chains located in the AChE active site gorge. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 23526889-5 2013 In the QM/MM re-refined donepezil structure, coordinate errors that previously existed in the PDB deposited geometry were improved leading to an improvement of the modeling of the interaction between donepezil and the aromatic side chains located in the AChE active site gorge. Donepezil 200-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 24097403-1 2013 RATIONALE: 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer"s disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 24097403-1 2013 RATIONALE: 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer"s disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 24081314-2 2013 The acetylcholinesterase inhibitors donepezil, rivastigmine, and galantamine and the NMDA-receptor antagonist memantine have produced modest but apparently persistent improvements in cognition, activities of daily living, and behavior in patients with disease severity ranging from mild to severe. Donepezil 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24379961-4 2013 Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine (Ach) and therefore, through this mechanism improve the symptoms of AD. Donepezil 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23838422-5 2013 Particularly, 6-chloro-pyridonepezil8 is 625-fold more selective for hAChE than for hBuChE and compared to donepezil is equipotent for the inhibition of hAChE. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-74 23838422-5 2013 Particularly, 6-chloro-pyridonepezil8 is 625-fold more selective for hAChE than for hBuChE and compared to donepezil is equipotent for the inhibition of hAChE. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-158 23199476-2 2013 Donepezil is one of most used AChEIs in AD therapy, acting as a dual binding site, reversible inhibitor of AChE with high selectivity over butyrylcholinesterase (BChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 23782591-1 2013 BACKGROUND: The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer"s disease (AD). Donepezil 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23653426-1 2013 OBJECTIVE: Chronic use of the acetylcholinesterase inhibitor donepezil has been found to improve mood or to induce mania/hypomania in many neuropsychiatric patients with altered cholinergic and dopaminergic tone. Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 23273608-0 2013 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 23777291-9 2013 Finally, molecular docking of these novel molecules into the AChE binding domain indicated that three molecules (6c, 7c, and 7h) should have significantly higher affinities and solvation energies than the known standard drug donepezil. Donepezil 225-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 23881696-4 2013 The most potent AChE inhibitor was found as compound 2g (IC50 = 0.53 +- 0.001 microM) followed by compounds 2f (IC50 = 0.74 +- 0.001 microM) and 2j (IC50 = 0.89 +- 0.002 microM) when compared with donepezil (IC50 = 0.048 +- 0.001 microM). Donepezil 200-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 24145276-0 2013 A case report on the use of an acetylcholinesterase inhibitor (donepezil) in traumatic brain injury. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 24145276-2 2013 Our patient who suffered TBI was started on a trial of an acetylcholinesterase inhibitor (Donepezil) for five weeks. Donepezil 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 23447373-3 2013 We hypothesized that older adults with mild memory deficits would show behavioral and functional network enhancements with an acetylcholinesterase inhibitor treatment (donepezil) when compared to a placebo control group. Donepezil 168-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 23408070-4 2013 Donepezil, galantamine and rivastigmine are acetylcholinesterase inhibitors with different pharmacodynamic and pharmacokinetic profiles. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 23408070-5 2013 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 23408070-5 2013 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 23215841-3 2013 AREAS COVERED: This article briefly reviews about donepezil, a highly selective (IC(50) = 6.7 nM) centrally acting reversible acetylcholinesterase inhibitor that has been approved by FDA for treating cognitive deficit states such as in Alzheimer"s disease and its uses in clinical trials for the treatment of schizophrenia. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 23431890-6 2013 Some anticholinesterase, like donepezil, exhibits high specificity for centrally active acetylcholinesterase and raise ACh levels in the brain. Donepezil 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 24211638-4 2013 Compound 10c was 46-fold more potent than standard drug donepezil against AChE. Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 23372236-2 2012 Donepezil hydrochloride is a potent, reversible, and highly selective inhibitor of acetylcholinesterase (AChE). Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23035744-2 2012 Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer"s disease drug, binds differently to human AChE than it does to Torpedo AChE. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 23035744-2 2012 Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer"s disease drug, binds differently to human AChE than it does to Torpedo AChE. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 23035744-2 2012 Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer"s disease drug, binds differently to human AChE than it does to Torpedo AChE. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 24092978-1 2013 OBJECTIVE: While acetylcholinesterase inhibitors, such as donepezil, galantamine, and rivastig-mine, are beneficial in treating behavioral symptoms of patients with Alzheimer"s disease (AD), their dose-limiting effects include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 23279148-3 2012 Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 22595038-0 2012 Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study. Donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 24052808-1 2012 Anomalous action of human acetylcholinesterase (hAChE) in Alzheimer"s disease (AD) was restrained by various AChE inhibitors, of which the specific and potent lead candidate Donepezil is used for treating the disease AD. Donepezil 174-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24052808-1 2012 Anomalous action of human acetylcholinesterase (hAChE) in Alzheimer"s disease (AD) was restrained by various AChE inhibitors, of which the specific and potent lead candidate Donepezil is used for treating the disease AD. Donepezil 174-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 24052808-1 2012 Anomalous action of human acetylcholinesterase (hAChE) in Alzheimer"s disease (AD) was restrained by various AChE inhibitors, of which the specific and potent lead candidate Donepezil is used for treating the disease AD. Donepezil 174-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 22915447-2 2012 This report presents an efficacy and safety study of the acetylcholinesterase inhibitor donepezil hydrochloride in PDD. Donepezil 88-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 22238217-0 2012 Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22238217-0 2012 Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 22238217-2 2012 We evaluated the feasibility, tolerance, and impact of a pilot pharmacologic intervention with the acetylcholinesterase (AChe) inhibitor, donepezil, in pediatric brain tumor (BT) survivors at risk for neurocognitive dysfunction. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 22238217-2 2012 We evaluated the feasibility, tolerance, and impact of a pilot pharmacologic intervention with the acetylcholinesterase (AChe) inhibitor, donepezil, in pediatric brain tumor (BT) survivors at risk for neurocognitive dysfunction. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 22691879-1 2012 To study prospectively influences of donepezil, an acetylcholinesterase inhibitor against Alzheimer disease, on cardiovascular system, we evaluated cardiovascular changes occurring during new initialized treatment with donepezil in 49 dementia patients over 6 months. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 22692245-2 2012 The acetylcholinesterase inhibition activity was assayed according to Ellman"s method using donepezil as reference. Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 22534665-0 2012 Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 22561476-0 2012 Successful treatment of musical hallucinations with the acetylcholinesterase inhibitor donepezil. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 22534665-1 2012 New series of indole derivatives analogous to donepezil, a well known anti-Alzheimer and acetylcholinesterase inhibitor drug, was synthesized. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 22534665-4 2012 Most of the compounds were found to have potent acetylcholinesterase inhibitor activity compared to donepezil as standard. Donepezil 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 22427467-4 2012 The goal of our study was to examine donepezil - an acetylcholinesterase inhibitor (AChEI) currently used in AD therapy -, and to what degree it influences the serum adipokine levels and metabolic parameters of AD patients. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 22245641-1 2012 Acetylcholinesterase inhibitors (AChEIs), such as donepezil, have been shown to improve cognition in mild to moderate Alzheimer"s disease (AD) patients. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21666432-0 2012 Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 21666432-0 2012 Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 21901320-2 2012 OBJECTIVE: Preclinical and clinical experiments were designed to examine the utility of the scopolamine-induced cognitive impairment model in predicting pharmacodynamic signals of putatively procognitive compounds, utilizing the acetylcholinesterase inhibitor donepezil for illustration. Donepezil 260-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-249 22832236-1 2012 BACKGROUND: Although donepezil, an acetylcholinesterase inhibitor, has been proved to be effective in ameliorating cognitive impairment in Parkinson"s disease with dementia (PDD), the responsiveness of patients to donepezil therapy varies. Donepezil 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 22832236-2 2012 [5-(11)C-methoxy]donepezil, the radiolabeled form of donepezil, is a ligand for positron emission tomography (PET), which can be exploited for the quantitative analysis of donepezil binding to acetylcholinesterase and for cholinergic imaging. Donepezil 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 22832236-2 2012 [5-(11)C-methoxy]donepezil, the radiolabeled form of donepezil, is a ligand for positron emission tomography (PET), which can be exploited for the quantitative analysis of donepezil binding to acetylcholinesterase and for cholinergic imaging. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 22832236-8 2012 CONCLUSION: The results suggest that donepezil therapy is more effective in patients with less decrease in acetylcholinesterase, a binding site of donepezil, at least in the specific cognitive domain. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 22832236-8 2012 CONCLUSION: The results suggest that donepezil therapy is more effective in patients with less decrease in acetylcholinesterase, a binding site of donepezil, at least in the specific cognitive domain. Donepezil 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 22465999-1 2012 Alzheimer"s disease (AD) is a neurodegenerative disorder often treated with donepezil, an acetylcholinesterase inhibitor. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110