PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26114860-2 2015 Donepezil is a well-known acetylcholinesterase inhibitor used clinically to treat cognitive dysfunction in Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase Mus musculus 26-46 26558196-0 2015 The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Donepezil 35-44 acetylcholinesterase Mus musculus 62-82 26558196-10 2015 CONCLUSION: In vivo, tacrine and donepezil can inhibit the expression of AChE; the decrease of AChE expression in the retina is beneficial for the development of the retina. Donepezil 33-42 acetylcholinesterase Mus musculus 73-77 27441211-0 2015 Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase. Donepezil 0-9 acetylcholinesterase Mus musculus 105-125 27441211-1 2015 OBJECTIVE: Donepezil, an inhibitor of acetylcholinesterase (AChE) targeting the brain, is a common medication for Alzheimer"s disease. Donepezil 11-20 acetylcholinesterase Mus musculus 38-58 27441211-1 2015 OBJECTIVE: Donepezil, an inhibitor of acetylcholinesterase (AChE) targeting the brain, is a common medication for Alzheimer"s disease. Donepezil 11-20 acetylcholinesterase Mus musculus 60-64 25890242-8 2015 The effects on neuromodulator temporal dynamics were sensitive to the Monoamine oxidase-A (MAO-A) antagonist clorgyline (for norepinephrine and serotonin) and the ACh-E inhibitor donepezil (for acetylcholine). Donepezil 179-188 acetylcholinesterase Mus musculus 163-168 25744714-1 2015 The main purpose of the present study is to investigate the influence of donepezil, a well-known acetylcholinesterase (AChE) inhibitor, on amyloid-beta (Abeta)-associated mitochondrial dysfunction, in order to gain a better understanding of the neuroprotective effects of this clinically used anti-Alzheimer"s disease (AD) drug. Donepezil 73-82 acetylcholinesterase Mus musculus 97-117 25744714-1 2015 The main purpose of the present study is to investigate the influence of donepezil, a well-known acetylcholinesterase (AChE) inhibitor, on amyloid-beta (Abeta)-associated mitochondrial dysfunction, in order to gain a better understanding of the neuroprotective effects of this clinically used anti-Alzheimer"s disease (AD) drug. Donepezil 73-82 acetylcholinesterase Mus musculus 119-123 23147415-6 2013 HZ mice are also more sensitive to the peripheral application of the selective AChE inhibitor donepezil or the mixed inhibitor physostigmine; extracellular ACh levels rise significantly after administration of both drugs; also glucose levels are moderately increased indicating potentially non-cholinergic effects of donepezil. Donepezil 94-103 acetylcholinesterase Mus musculus 79-83 24911319-4 2014 The aim of the present study was to determine if the acetylcholinesterase inhibitor donepezil has the ability to reverse nicotine withdrawal-induced deficits in contextual learning. Donepezil 84-93 acetylcholinesterase Mus musculus 53-73 24214089-5 2014 At last, we provide clear evidence that while the hypothermic effect of the muscarinic agonist oxotremorine is based on a central mechanism, in contrast, the acetylcholinesterase inhibitor donepezil decreases body temperature by its action in the periphery. Donepezil 189-198 acetylcholinesterase Mus musculus 158-178 25036424-7 2014 Subchronic treatment with MK-801 caused lasting memory deficits, which were ameliorated by acute doses of an acetylcholinesterase inhibitor (donepezil) and an alpha-7 nicotinic agonist (PHA 568487), but were unaffected by acute administration of the atypical antipsychotic risperidone. Donepezil 141-150 acetylcholinesterase Mus musculus 109-129 24487798-0 2014 Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C. Neurodegenerative processes are often accompanied by disruption of cholinergic systems; therefore, acetylcholinesterase (AChE) inhibitors (AChEIs) may have therapeutic potential in some neurological conditions. Donepezil 0-9 acetylcholinesterase Mus musculus 260-280 24487798-0 2014 Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C. Neurodegenerative processes are often accompanied by disruption of cholinergic systems; therefore, acetylcholinesterase (AChE) inhibitors (AChEIs) may have therapeutic potential in some neurological conditions. Donepezil 0-9 acetylcholinesterase Mus musculus 282-286 24487798-4 2014 Donepezil treatment reduced cholesterol accumulation in adult neural stem cells in vitro, and it downregulated the expression of the cholesterol synthesis factors" sterol regulatory element-binding proteins and 3-hydroxy-3-methylglutaryl-CoA reductase in the cerebellum, implying that AChE activity might be associated with cholesterol homeostasis. Donepezil 0-9 acetylcholinesterase Mus musculus 285-289 22369073-1 2012 Donepezil {(RS)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one} is a reversible acetylcholinesterase inhibitor and used for treatment of patients with AD (Alzheimer"s disease). Donepezil 0-9 acetylcholinesterase Mus musculus 103-123 23276665-5 2013 Acute single-dose administrations of memantine, a low-to-moderate-affinity N-methyl-d-aspartate (NMDA) antagonist, showed improvements in working memory deficits at 4 months of age, whereas donepezil, an acetylcholinesterase (AChE) inhibitor, did not. Donepezil 190-199 acetylcholinesterase Mus musculus 204-224 22826038-1 2012 Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil (Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for Alzheimer"s disease (AD) treatment. Donepezil 75-84 acetylcholinesterase Mus musculus 125-129 22826038-1 2012 Cerebrolysin (Cbl) shows neurotrophic and neuroprotective properties while donepezil (Dnp) is a potent acetylcholinesterase (AChE) inhibitor, both drugs are prescribed for Alzheimer"s disease (AD) treatment. Donepezil 86-89 acetylcholinesterase Mus musculus 125-129 22553034-8 2012 CNS inflammatory responses were similar in normal and lesioned animals and the acetylcholinesterase inhibitor, donepezil (1 mg/kg), protected against the acute cognitive deficits in this cholinergic-dependent task. Donepezil 111-120 acetylcholinesterase Mus musculus 79-99 21750701-1 2011 BACKGROUND: We have previously demonstrated that the chronic intervention in the cholinergic system by donepezil, an acetylcholinesterase inhibitor, plays a beneficial role in suppressing long-term cardiac remodeling after myocardial infarction (MI). Donepezil 103-112 acetylcholinesterase Mus musculus 117-137 21820013-3 2011 We compared the effects of a selective BuChE inhibitor, N1-phenethyl-norcymserine (PEC), rivastigmine and donepezil (an AChE-selective inhibitor) on cognitive dysfunction induced by amyloid-beta peptide (Abeta(1-40)) in mice. Donepezil 106-115 acetylcholinesterase Mus musculus 120-124 21820453-4 2011 In the present study, we investigated whether the acetylcholinesterase inhibitors donepezil and galantamine could influence neurotrophin receptor signaling in the brain. Donepezil 82-91 acetylcholinesterase Mus musculus 50-70 21419082-11 2011 High- and low-dose HNYCF and donepezil hydrochloride reduced the content of AChE, increased the activity of ChAT (P<0.01, P<0.05) and improved the content of ACh in hippocampus (P<0.05); high- and low-dose HNYCF and donepezil hydrochloride increased the content of ACh in cortex (P<0.05). Donepezil 29-52 acetylcholinesterase Mus musculus 76-80 21419082-12 2011 Donepezil hydrochloride reduced the content of AChE in cortex (P<0.05), however, high- and low-dose HNYCF had no obvious influence (P>0.05). Donepezil 0-23 acetylcholinesterase Mus musculus 47-51 22114680-0 2011 Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. Donepezil 104-113 acetylcholinesterase Mus musculus 73-93 22114680-3 2011 We hypothesized that pretreatment with the acetylcholinesterase inhibitor donepezil, which has been approved by the Food and Drug Administration (FDA) for the treatment of Alzheimer"s disease, prevents isoflurane-induced spatial memory impairment in aged mice. Donepezil 74-83 acetylcholinesterase Mus musculus 43-63 22114680-12 2011 In conclusions, pretreatment with the AChE inhibitor donepezil prevented isoflurane-induced spatial memory impairment in aged mice. Donepezil 53-62 acetylcholinesterase Mus musculus 38-42 19318594-2 2009 The selective acetylcholinesterase inhibitor donepezil increases serum IGF-I levels in elderly subjects. Donepezil 45-54 acetylcholinesterase Mus musculus 14-34 20723895-1 2010 OBJECTIVE: Donepezil, a reversible acetylcholinesterase inhibitor, improves cognitive function of Alzheimer"s disease. Donepezil 11-20 acetylcholinesterase Mus musculus 35-55 20219155-5 2010 Donepezil, an AChE inhibitor (1 mg/kg) increased the extracellular ACh release in the PFC, whereas it had no effect on the memory impairment in Meth-treated mice. Donepezil 0-9 acetylcholinesterase Mus musculus 14-18 20460870-2 2010 Donepezil, a potent acetylcholinesterase (AChE) inhibitor is reported to rescue neurons from excitotoxic injury in culture. Donepezil 0-9 acetylcholinesterase Mus musculus 20-40 20460870-2 2010 Donepezil, a potent acetylcholinesterase (AChE) inhibitor is reported to rescue neurons from excitotoxic injury in culture. Donepezil 0-9 acetylcholinesterase Mus musculus 42-46 19799879-1 2009 Donepezil, an acetylcholinesterase inhibitor, is an approved drug for the treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase Mus musculus 14-34 17395211-5 2007 It was found that administration of tacrine, rivastigmine and donepezil in mice significantly attenuated the LPS induced increased levels of IL-2 along with the significant reduction of AChE activity predominantly in salt soluble (SS) fraction as compared to the detergent soluble (DS) fraction in a dose dependent manner. Donepezil 62-71 acetylcholinesterase Mus musculus 186-190 18462717-6 2008 Donepezil, an acetylcholinesterase inhibitor and the most widely used drug for AD treatment was employed as a positive control. Donepezil 0-9 acetylcholinesterase Mus musculus 14-34 18462717-7 2008 The activity of acetylcholinesterase was inhibited significantly by E-harpagoside or MCA-Hg within the cortex and hippocampus to a level similar to that observed in mice treated with donepezil (2 mg/kg body weight, p.o.). Donepezil 183-192 acetylcholinesterase Mus musculus 16-36 18336929-2 2008 Therefore, the present study was planned to study the effect of donepezil, an anticholinesterase antidementia drug, insulin and melatonin, an antioxidant, on memory deficit and acetylcholinesterase (AChE) activity in brain areas of scopolamine-induced amnesic mice. Donepezil 64-73 acetylcholinesterase Mus musculus 177-197 18336929-2 2008 Therefore, the present study was planned to study the effect of donepezil, an anticholinesterase antidementia drug, insulin and melatonin, an antioxidant, on memory deficit and acetylcholinesterase (AChE) activity in brain areas of scopolamine-induced amnesic mice. Donepezil 64-73 acetylcholinesterase Mus musculus 199-203 18336929-11 2008 AChE activity in DS fraction of scopolamine amnesic mice was inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in SS fraction was not much affected. Donepezil 74-83 acetylcholinesterase Mus musculus 0-4 17912499-2 2008 However, clinical data suggest that the acetylcholinesterase (AChE) inhibitors galantamine and donepezil have different effects on negative and cognitive symptoms in schizophrenia. Donepezil 95-104 acetylcholinesterase Mus musculus 40-60 17912499-2 2008 However, clinical data suggest that the acetylcholinesterase (AChE) inhibitors galantamine and donepezil have different effects on negative and cognitive symptoms in schizophrenia. Donepezil 95-104 acetylcholinesterase Mus musculus 62-66 19470293-3 2009 Rivastigmine is an inhibitor of both AChE and butyrylcholinesterase (BChE) whereas donepezil is a selective inhibitor of AChE. Donepezil 83-92 acetylcholinesterase Mus musculus 121-125 18544893-8 2008 Donepezil, an acetylcholinesterase inhibitor, reversed the learning and mnemonic dysfunction in all four tasks. Donepezil 0-9 acetylcholinesterase Mus musculus 14-34 15708480-6 2005 The wake-promoting efficacy of the acetylcholinesterase inhibitor donepezil was lower in plaque-bearing Tg2576 mice than in controls. Donepezil 66-75 acetylcholinesterase Mus musculus 35-55 17057756-1 2006 BACKGROUND AND PURPOSE: The acetylcholinesterase inhibitor, donepezil, is also a high affinity sigma(1) receptor agonist. Donepezil 60-69 acetylcholinesterase Mus musculus 28-48 34776532-8 2022 Our results show that DNPZ with tetrahedral geometry has 3-fold higher AChE inhibition as compared to compound #20 with planar trigonal pyramidal geometry. Donepezil 22-26 acetylcholinesterase Mus musculus 71-75 10368299-0 1999 Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Donepezil 56-63 acetylcholinesterase Mus musculus 13-33 10368299-2 1999 E2020, marketed as Aricept, is a member of a large family of N-benzylpiperidine-based acetylcholinesterase (AChE) inhibitors developed, synthesized and evaluated by the Eisai Company in Japan. Donepezil 19-26 acetylcholinesterase Mus musculus 86-106 10368299-2 1999 E2020, marketed as Aricept, is a member of a large family of N-benzylpiperidine-based acetylcholinesterase (AChE) inhibitors developed, synthesized and evaluated by the Eisai Company in Japan. Donepezil 19-26 acetylcholinesterase Mus musculus 108-112 8039548-1 1994 The reversible noncovalent inhibitor of acetylcholinesterase (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride (E2020) was shown to inhibit electric eel acetylcholinesterase with high affinity in a mixed competitive-non-competitive way (Ki = 8.2 nM; Ki" = 13 nM). Donepezil 143-148 acetylcholinesterase Mus musculus 40-60 34515019-16 2021 The combination also decreases transfer latency time in EPM and acetylcholinesterase levels in the brain as compared to standard donepezil. Donepezil 129-138 acetylcholinesterase Mus musculus 64-84 35203483-10 2022 Compared to mice in the control group, the brain extracts in the vitisin A-treated mice or donepezil-treated mice showed significant reductions in AChE activities and malondialdehyde levels (p < 0.05), and elevated the reduced protein expressions of brain-derived neurotrophic factor (BDNF) and BDNF receptor, tropomyosin receptor kinase B (TrkB). Donepezil 91-100 acetylcholinesterase Mus musculus 147-151 33851543-1 2021 Donepezil is a centrally-acting acetylcholinesterase (AChE) inhibitor with therapeutic potential in inflammatory diseases; however, the underlying autonomic and cholinergic mechanisms remain unclear. Donepezil 0-9 acetylcholinesterase Mus musculus 54-58 29564727-4 2018 A10E effectively attenuated impairments of learning and memory to a similar extent as donepezil, an inhibitor of AChE used for treating Alzheimer"s disease (AD). Donepezil 86-95 acetylcholinesterase Mus musculus 113-117 32118214-5 2020 The brain extracts of the mice in the DC or donepezil group showed reduced AChE activities and higher ORAC activities and also showed a significant difference compared to those in the control group (P < 0.05, 0.01, or 0.001). Donepezil 44-53 acetylcholinesterase Mus musculus 75-79 31402621-3 2019 In the present study, we evaluated the therapeutic potential of donepezil, a reversible acetylcholinesterase inhibitor approved by the Food and Drug Administration, in a mouse model of Dravet syndrome (Scn1a+/- ). Donepezil 64-73 acetylcholinesterase Mus musculus 88-108 32953572-1 2020 AIM: To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR). Donepezil 73-82 acetylcholinesterase Mus musculus 42-62 32953572-1 2020 AIM: To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR). Donepezil 73-82 acetylcholinesterase Mus musculus 64-68 32872194-6 2020 Moreover, E100 modulated disturbed anxiety levels, but failed to modulate hyperactivity parameters, whereas the reference AChE inhibitor donepezil (DOZ, one milligram per kilogram) significantly obliterated the increased hyperactivity measures of tested mice. Donepezil 137-146 acetylcholinesterase Mus musculus 122-126 32872194-6 2020 Moreover, E100 modulated disturbed anxiety levels, but failed to modulate hyperactivity parameters, whereas the reference AChE inhibitor donepezil (DOZ, one milligram per kilogram) significantly obliterated the increased hyperactivity measures of tested mice. Donepezil 148-151 acetylcholinesterase Mus musculus 122-126 32184102-6 2020 Donepezil, a well-known ACHE inhibitor, was administrated by daily gavage. Donepezil 0-9 acetylcholinesterase Mus musculus 24-28 31302713-1 2019 PURPOSE: These studies determined whether the acetylcholinesterase inhibitors, donepezil and galantamine, both of which are approved for the treatment of cognitive deficits in Alzheimer"s disease, can prevent or reverse spatial memory deficits in mice induced by cyclophosphamide and doxorubicin, cytotoxic agents commonly used to treat breast cancer. Donepezil 79-88 acetylcholinesterase Mus musculus 46-66 30626892-5 2019 Separate cohorts were analyzed after pretreatment with donepezil, an AChE inhibitor, in aged mice or with murine-p75-saporin (mu-p75-sap), a cholinergic-specific immunotoxin, in adult mice. Donepezil 55-64 acetylcholinesterase Mus musculus 69-73 29761010-9 2018 Donepezil, an inhibitor of acetylcholinesterase (AChE), was administered in another cohort mice for 4 weeks. Donepezil 0-9 acetylcholinesterase Mus musculus 27-47 29463072-6 2018 The pharmacological effects of donepezil are dependent upon its concentration and AChE activity; therefore, we assessed the effects of donepezil on learning and memory using a Y-maze in mice. Donepezil 31-40 acetylcholinesterase Mus musculus 82-86 29761010-9 2018 Donepezil, an inhibitor of acetylcholinesterase (AChE), was administered in another cohort mice for 4 weeks. Donepezil 0-9 acetylcholinesterase Mus musculus 49-53 28613859-0 2017 Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation. Donepezil 0-9 acetylcholinesterase Mus musculus 24-44 28613859-1 2017 With the aim of reducing side effects of acetylcholinesterase inhibitors (AChEIs) during symptomatic treatment of Alzheimer"s disease, we report herein a new class of donepezil-based "bio-oxidizable" prodrugs 1 designed to be converted into dual binding site AChEIs 2. Donepezil 167-176 acetylcholinesterase Mus musculus 41-61 28125507-6 2017 More recently, we have shown that a group of donepezil-huprine heterodimers exerts a highly potent and selective inhibitory action on AChE both in vitro and ex vivo, simultaneously interacting with both peripheral and catalytic binding sites, and inhibiting the beta-amyloid aggregation, whereas some levetiracetam-huprine hybrids have been shown to reduce epileptiform activity, neuroinflammation and amyloid burden in an animal model of AD. Donepezil 45-54 acetylcholinesterase Mus musculus 134-138 28286520-6 2017 AChE inhibitors were measured with limits of detection, 149 nM and 22.3 nM for galanthamine and donepezil, respectively. Donepezil 96-105 acetylcholinesterase Mus musculus 0-4 27796293-3 2016 Here, we co-administered 4-(2-hydroxyethyl)-1-piperazinepropane-sulphonic acid (EPPS), an amyloid-clearing chemical, and donepezil, an acetylcholinesterase inhibitor, to determine whether they could serve complementary roles for each other in regards to AD treatment. Donepezil 121-130 acetylcholinesterase Mus musculus 135-155 25823512-7 2016 Donepezil treatment significantly inhibited the STZ induced neurotoxicity, altered choline level, AChE activity, lowered glucose uptake and mitochondrial stress. Donepezil 0-9 acetylcholinesterase Mus musculus 98-102 27373848-0 2016 Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation. Donepezil 0-9 acetylcholinesterase Mus musculus 14-34 27373848-1 2016 We have previously demonstrated that the pharmacotherapy with donepezil, an acetylcholinesterase inhibitor, suppresses cardiac remodeling in a mouse model of ischemic heart failure after myocardial infarction (MI). Donepezil 62-71 acetylcholinesterase Mus musculus 76-96 27373848-9 2016 These results suggest that a cholinergic anti-inflammatory pathway would not be involved in the anti-inflammatory effect of donepezil and that the specific characteristics of donepezil in suppressing the LPS-induced cytokine release and the NF-kappaB activation would be independent of its acetylcholinesterase inhibition. Donepezil 175-184 acetylcholinesterase Mus musculus 290-310 27291828-3 2016 Donepezil is one of the acetylcholinesterase (AChE) inhibitor approved for use across the full spectrum of these cognitive disorders. Donepezil 0-9 acetylcholinesterase Mus musculus 24-44 27291828-3 2016 Donepezil is one of the acetylcholinesterase (AChE) inhibitor approved for use across the full spectrum of these cognitive disorders. Donepezil 0-9 acetylcholinesterase Mus musculus 46-50 27150930-5 2016 Furthermore, we clarified the pharmacological profiles of the acetylcholinesterase inhibitors donepezil, galantamine, and rivastigmine, providing novel insights into their mechanisms of action. Donepezil 94-103 acetylcholinesterase Mus musculus 62-82 28096851-5 2016 Donepezil (2 mg/kg) an AChE inhibitor to treat Alzheimer disease was injected intraperitoneally once a day for two weeks starting from post-infection day 90. Donepezil 0-9 acetylcholinesterase Mus musculus 23-27 28096851-9 2016 RESULTS: Toxoplasma infection impaired spatial leaning and short term spatial memory of the infected BALB/c mice, whereas donepezil, an AChE inhibitor, improved impairments induced by Toxoplasma infection. Donepezil 122-131 acetylcholinesterase Mus musculus 136-140 28096851-10 2016 CONCLUSION: T. gondii infection through increasing AChE reduces the level of Acetylcholine (Ach) and consequently affects learning and memory activity in infected hosts, whereas, donepezil as an AChE inhibitor improves these impairments by restoring ACh levels at synapses of neurons in brain. Donepezil 179-188 acetylcholinesterase Mus musculus 195-199 26554604-3 2016 In the current study, we examined the effects of HFD on brain pathology and further evaluated whether donepezil, an AChE inhibitor with neuroprotective functions, could suppress the ongoing HFD induced pathological changes in the brain. Donepezil 102-111 acetylcholinesterase Mus musculus 116-120 26554604-6 2016 Interestingly, donepezil administration with HFD suppressed HFD induced increases in AChE activity, and partially reversed HFD effects on microglial reactivity and the levels of mTOR signaling proteins in the brain when compared to the mice on LFD alone. Donepezil 15-24 acetylcholinesterase Mus musculus 85-89 27284332-3 2016 Donepezil is an acetylcholinesterase inhibitor that has a protective effect on retinal ganglion cells in vitro and in vivo, and it is understood that donepezil increases the expression of a heat shock protein 70 (Hsp70), which serves to protect neurons. Donepezil 0-9 acetylcholinesterase Mus musculus 16-36 27284332-3 2016 Donepezil is an acetylcholinesterase inhibitor that has a protective effect on retinal ganglion cells in vitro and in vivo, and it is understood that donepezil increases the expression of a heat shock protein 70 (Hsp70), which serves to protect neurons. Donepezil 150-159 acetylcholinesterase Mus musculus 16-36