PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30311190-0	2019	Rosiglitazone up-regulates glial fibrillary acidic protein via HB-EGF secreted from astrocytes and neurons through PPARgamma pathway and reduces apoptosis in high-fat diet-fed mice.	Rosiglitazone	0-13	glial fibrillary acidic protein	Mus musculus	27-58	
30311190-5	2019	Treatment with HB-EGF-siRNA and EGFR inhibitors showed that the rosiglitazone-induced HB-EGF and p-EFGR were interdependent, which participated in GFAP increase.	Rosiglitazone	64-77	glial fibrillary acidic protein	Mus musculus	147-151	
30311190-6	2019	Interestingly, we observed that rosiglitazone could induce cellular and secreted-HB-EGF in neurons also, contributing toward the activated EGFR-induced GFAP in astrocytes.	Rosiglitazone	32-45	glial fibrillary acidic protein	Mus musculus	152-156	
30311190-9	2019	Subsequently, we examined effects of rosiglitazone in a high-fat diet-fed diabetes mouse model, and supporting observations in the normal cortical cells, identified a rosiglitazone-induced GFAP, astrocyte and neuronal HB-EGF and secreted-HB-EGF in the cerebral cortex of diabetic mice.	Rosiglitazone	167-180	glial fibrillary acidic protein	Mus musculus	189-193	
30311190-10	2019	Moreover, assessing relevance of increased HB-EGF and GFAP revealed an anti-apoptotic role of rosiglitazone in the cerebral cortex, supported by a GFAP-siRNA as well as HB-EGF-siRNA-mediated increase in cleaved-caspase 3 and 9 levels in the rosiglitazone-treated astrocyte-neuron coculture.	Rosiglitazone	94-107	glial fibrillary acidic protein	Mus musculus	54-58	
30311190-10	2019	Moreover, assessing relevance of increased HB-EGF and GFAP revealed an anti-apoptotic role of rosiglitazone in the cerebral cortex, supported by a GFAP-siRNA as well as HB-EGF-siRNA-mediated increase in cleaved-caspase 3 and 9 levels in the rosiglitazone-treated astrocyte-neuron coculture.	Rosiglitazone	94-107	glial fibrillary acidic protein	Mus musculus	147-151	
30311190-11	2019	Overall, our study indicates that rosiglitazone may protect the brain, via a PPARgamma-dependent HB-EGF/EGFR signaling and increased GFAP.	Rosiglitazone	34-47	glial fibrillary acidic protein	Mus musculus	133-137	
30311190-3	2019	We first detected that rosiglitazone promoted glial fibrillary acidic protein (GFAP) expression in primary astrocytes as well as the mouse cerebral cortex, associated with increased EGFR activation.	Rosiglitazone	23-36	glial fibrillary acidic protein	Mus musculus	46-77	
30311190-3	2019	We first detected that rosiglitazone promoted glial fibrillary acidic protein (GFAP) expression in primary astrocytes as well as the mouse cerebral cortex, associated with increased EGFR activation.	Rosiglitazone	23-36	glial fibrillary acidic protein	Mus musculus	79-83