PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28232477-8 2017 Using rosiglitazone, we queried the effects of rosiglitazone on Klotho/Wnt5A cross-talk, in vitro and in vivo, and the implications of that for targeted therapy in young versus aged animals.Results: We show that rosiglitazone increases klotho and decreases Wnt5A in tumor cells, reducing the burden of both BRAF inhibitor-sensitive and BRAF inhibitor-resistant tumors in aged, but not young mice. Rosiglitazone 47-60 wingless-type MMTV integration site family, member 5A Mus musculus 71-76 28232477-8 2017 Using rosiglitazone, we queried the effects of rosiglitazone on Klotho/Wnt5A cross-talk, in vitro and in vivo, and the implications of that for targeted therapy in young versus aged animals.Results: We show that rosiglitazone increases klotho and decreases Wnt5A in tumor cells, reducing the burden of both BRAF inhibitor-sensitive and BRAF inhibitor-resistant tumors in aged, but not young mice. Rosiglitazone 47-60 wingless-type MMTV integration site family, member 5A Mus musculus 71-76