PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31166382-0	2019	Downregulation of lncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation.	Imatinib Mesylate	47-55	CCDC26 long non-coding RNA	Homo sapiens	25-31	
31166382-6	2019	The expression of a series of reported drug resistance-related lncRNAs, including CCDC26, ARF, H19, NBR2, NEAT1, and HOTAIR, in GIST cells treated with imatinib H19 was examined at various time-points by qRT-PCR.	Imatinib Mesylate	152-160	CCDC26 long non-coding RNA	Homo sapiens	82-88	
31166382-7	2019	Based on our results and published literature, CCDC26, a strongly down-regulated lncRNA following imatinib treatment, was chosen as our research target.	Imatinib Mesylate	98-106	CCDC26 long non-coding RNA	Homo sapiens	47-53	
31166382-8	2019	GIST cells with high expression of CCDC26 were sensitive to imatinib treatment while knockdown of CCDC26 significantly increased the resistance to imatinib.	Imatinib Mesylate	60-68	CCDC26 long non-coding RNA	Homo sapiens	35-41	
31166382-8	2019	GIST cells with high expression of CCDC26 were sensitive to imatinib treatment while knockdown of CCDC26 significantly increased the resistance to imatinib.	Imatinib Mesylate	147-155	CCDC26 long non-coding RNA	Homo sapiens	98-104	
31166382-10	2019	Moreover, IGF-1R inhibition reversed CCDC26 knockdown-mediated imatinib resistance in GIST.	Imatinib Mesylate	63-71	CCDC26 long non-coding RNA	Homo sapiens	37-43	
31166382-11	2019	These results indicated that treatments targeting CCDC26-IGF-1R axis would be useful in increasing sensitivity to imatinib in GIST.	Imatinib Mesylate	114-122	CCDC26 long non-coding RNA	Homo sapiens	50-56	
29423012-0	2018	CCDC26 knockdown enhances resistance of gastrointestinal stromal tumor cells to imatinib by interacting with c-KIT.	Imatinib Mesylate	80-88	CCDC26 long non-coding RNA	Homo sapiens	0-6	
29423012-3	2018	In the present study, we explored the biological function of the lncRNA coiled-coil domain-containing 26 (CCDC26) in imatinib resistance of GIST.	Imatinib Mesylate	117-125	CCDC26 long non-coding RNA	Homo sapiens	106-112	
29423012-4	2018	We found that human GIST-882 cells with lower CCDC26 expression were less sensitive to imatinib compared with GIST-T1 cells with higher CCDC26 expression.	Imatinib Mesylate	87-95	CCDC26 long non-coding RNA	Homo sapiens	46-52	
29423012-5	2018	CCDC26 expression decreased in a time-dependent manner in the presence of imatinib.	Imatinib Mesylate	74-82	CCDC26 long non-coding RNA	Homo sapiens	0-6	
29423012-6	2018	Moreover, small interfering RNA (siRNA) knockdown of CCDC26 increased GIST cell sensitivity to imatinib.	Imatinib Mesylate	95-103	CCDC26 long non-coding RNA	Homo sapiens	53-59	
29423012-9	2018	Lastly, we proved that inhibiting c-KIT can reverse CCDC26 knockdown-mediated imatinib resistance in GIST.	Imatinib Mesylate	78-86	CCDC26 long non-coding RNA	Homo sapiens	52-58	
29423012-10	2018	We suggest that CCDC26 knockdown can induce imatinib resistance in GIST cells by downregulating c-KIT expression.	Imatinib Mesylate	44-52	CCDC26 long non-coding RNA	Homo sapiens	16-22