PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27516570-9	2016	Both AEA and 2-AG are primarily agonists of the CB1 receptor and to a lower degree CB2 and TRPV1r eceptors, but 2-AG has stronger affinity for these receptors.	aea	5-8	cannabinoid receptor 2	Homo sapiens	83-86	
30460698-9	2018	SR144528, an antagonist of type 2 cannabinoid receptor (CB2), has a less-potent effect, suggesting that the CB1 receptor is overall involved in the AEA effect.	aea	148-151	cannabinoid receptor 2	Homo sapiens	56-59	
28261100-1	2017	The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonyl glycerol (2-AG).	aea	323-349	cannabinoid receptor 2	Homo sapiens	260-263	
25003845-2	2014	The best-known mammalian compound of this class is anandamide, N-arachidonoylethanolamine, one of the endogenous ligands of cannabinoid CB1 and CB2 receptors.	aea	63-89	cannabinoid receptor 2	Homo sapiens	144-147	
23512546-2	2013	The principal ligands of the endocannabinoid system are the lipid transmitters N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), which activate the two major cannabinoid receptors, CB1 and CB2.	aea	79-105	cannabinoid receptor 2	Homo sapiens	214-217	
22850591-1	2012	The endocannabinoid anandamide (N-arachidonoylethanolamine, AEA), a physiologically occurring bioactive compound on CB1 and CB2 receptors, has multiple physiological functions.	aea	32-58	cannabinoid receptor 2	Homo sapiens	124-127	
22850591-1	2012	The endocannabinoid anandamide (N-arachidonoylethanolamine, AEA), a physiologically occurring bioactive compound on CB1 and CB2 receptors, has multiple physiological functions.	aea	60-63	cannabinoid receptor 2	Homo sapiens	124-127	
17118807-4	2006	Cannabinoid type-1 (CB1) and CB2 receptors belong to the family of G protein-coupled receptors and are the primary targets of the endogenous cannabinoids N-arachidonoyl ethanolamine and 2-arachidonoyl glyerol.	aea	154-181	cannabinoid receptor 2	Homo sapiens	29-32	
10336536-3	1999	We have synthesized two analogs of N-arachidonylethanolamine (AEA), arachidonylcyclopropylamide (ACPA) and arachidonyl-2-chloroethylamide (ACEA), that bind to the CB1 receptor with very high affinity (KI values of 2.2 +/- 0.4 nM and 1.4 +/- 0.3 nM, respectively) and to the CB2 receptor with low affinity (KI values of 0.7 +/- 0.01 microM and 3.1 +/- 1.0 microM, respectively).	aea	62-65	cannabinoid receptor 2	Homo sapiens	274-277	
10336536-6	1999	Therefore, ACPA and ACEA are high-affinity agonists of the CB1 receptor but do not bind the CB2 receptor, suggesting that structural analogs of AEA can be designed with considerable selectivity for the CB1 receptor over the CB2 receptor.	aea	144-147	cannabinoid receptor 2	Homo sapiens	224-227	
34282702-2	2021	N-Arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG) represent two major endocannabinoids in the human body and they exert many of their cellular and organ system effects by activating the Gi/o protein-coupled, cannabinoid type 1 (CB1) and type 2 (CB2) receptors.	aea	0-26	cannabinoid receptor 2	Homo sapiens	274-277	
34282702-2	2021	N-Arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG) represent two major endocannabinoids in the human body and they exert many of their cellular and organ system effects by activating the Gi/o protein-coupled, cannabinoid type 1 (CB1) and type 2 (CB2) receptors.	aea	40-43	cannabinoid receptor 2	Homo sapiens	274-277	
33362550-1	2020	Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid receptor one (CB1) and cannabinoid receptor two (CB2).	aea	117-120	cannabinoid receptor 2	Homo sapiens	301-304	
17965731-1	2008	BACKGROUND AND PURPOSE: N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG) are endogenous cannabinoids binding to the cannabinoid receptors CB1 and CB2 to modulate neuronal excitability and synaptic transmission in primary afferent neurons.	aea	24-51	cannabinoid receptor 2	Homo sapiens	166-169	
17965731-1	2008	BACKGROUND AND PURPOSE: N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG) are endogenous cannabinoids binding to the cannabinoid receptors CB1 and CB2 to modulate neuronal excitability and synaptic transmission in primary afferent neurons.	aea	53-56	cannabinoid receptor 2	Homo sapiens	166-169	
10469888-2	1999	N- Arachidonoylethanolamine (anandamide) and some of its polyunsaturated congeners have been found in mammalian brain and shown to activate the CB1 and, with a lower efficacy, CB2 cannabinoid receptor subtypes.	aea	0-27	cannabinoid receptor 2	Homo sapiens	176-179	
35490598-5	2022	Transcript analysis of angiogenic factors of the vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) protein family demonstrated the ability of AEA to increase VEGF-C and VEGFR3 expression via cannabinoid receptors CB1 and CB2 while the placental growth factor (PlGF) was increased through CB1.	aea	169-172	cannabinoid receptor 2	Homo sapiens	248-251