PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28099911-7	2017	The increase of pAkt, pERK1/2 and cyclin D1 by bradykinin was prevented by the PI3K inhibitor Ly294002, the PLC inhibitors U73122 and neomycin, and/or the PKC inhibitor chelerythrine and the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	cyclin D1	Homo sapiens	34-43	
31196027-10	2019	In the following experiments, we found that CDCA2 regulated CCND1 expression through activating the PI3K/AKT pathway, and confirmed this using a specific PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	cyclin D1	Homo sapiens	60-65	
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin D1	Homo sapiens	96-104	
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	cyclin D1	Homo sapiens	85-94	
29393377-9	2018	Furthermore, overexpression of BCL6B resulted in upregulation of E-cadherin and downregulation of cyclin D1 and matrix metalloproteinase-9, which were strongly enhanced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	cyclin D1	Homo sapiens	98-138	
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin D1	Homo sapiens	30-39	
24603539-7	2014	Additionally, the increase in proliferation and cyclin D1 expression induced by miR-21 overexpression was almost completely blocked by Ly294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	cyclin D1	Homo sapiens	48-57	
28881576-6	2017	LY294002-treated CCSCs showed decreases in proliferation, sphere formation and self-renewal, in phosphorylation-dependent activation of Akt, and in expression of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin D1	Homo sapiens	162-171	
26802652-7	2016	Additionally, PI3K-specific inhibitor Ly294002 suppressed the expression of pPI3K (Tyr458), pAkt (Ser473), CCND1, and CDK4 in PC9-shPDCD4 and A549-shPDCD4 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cyclin D1	Homo sapiens	107-112	
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin D1	Homo sapiens	117-125	
24577313-10	2014	Furthermore, the HBx-induced increases in cyclin D1 expression and oval cell proliferation were completely abolished by treatment with either MEK inhibitor PD184352 or PI-3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	cyclin D1	Homo sapiens	42-51	
20930115-6	2011	Increases in cyclin D1 protein induced by FCS or LXA(4) were blocked by the PI3 kinase inhibitor, LY294002, and attenuated by FPR2 antagonism using Boc2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	cyclin D1	Homo sapiens	13-22	
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin D1	Homo sapiens	161-170	
22728329-8	2012	AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of beta-catenin and cyclin D1 and increased the plasma membrane localization of beta-catenin with E-cadherin, suggesting that these processes are regulated by the PKB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	cyclin D1	Homo sapiens	115-124	
16728278-13	2006	IGF-I phosphorylated Akt and upregulated cyclin D1 in the CD56(+) KMS-21-BM cells, which was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	cyclin D1	Homo sapiens	41-50	
21042767-6	2010	In addition, we found that the protein level of p27Kip1 was up-regulated and the protein level of cyclin D1 was down-regulated following LY294002 treatment in those MM cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	cyclin D1	Homo sapiens	98-107	
18769058-8	2008	rhHAPO enhanced the expression of cyclin D1, where as LY294002 inhibited the up-regulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin D1	Homo sapiens	34-43	
18769058-8	2008	rhHAPO enhanced the expression of cyclin D1, where as LY294002 inhibited the up-regulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin D1	Homo sapiens	94-103	
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	cyclin D1	Homo sapiens	72-81	
17007924-6	2007	Moreover, both LY294002 and rapamycin down-regulated the levels of c-Myc and cyclin D1 proteins in these cells, and their combination further decreased levels of these cell cycle-regulating proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin D1	Homo sapiens	77-86	
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D1	Homo sapiens	173-182	
12896906-5	2003	Serum treatment increased the pErbB3/p85 complexes and also stimulated phosphorylation of Akt and GSK3beta, increase in cyclin D1 and cell cycle progression, and these events were blocked by the Akt activation inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	cyclin D1	Homo sapiens	120-129	
15845746-8	2005	Conversely, inhibition of phosphoinositide 3 kinase by LY294002 or Wortmanin reversed the E2-induced GSK-3beta Ser9 inhibitory phosphorylation and blocked nuclear accumulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	cyclin D1	Homo sapiens	179-188	
10927622-2	2000	Unexpectedly, this elevation of cyclin D1 expression by all of these agents is inhibited by the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	cyclin D1	Homo sapiens	32-41	
11989975-4	2002	However, in the HT-29 cells pre-treated with PI3K inhibitor, LY294002, zinc induced further the p21(CiP/WAF) induction whereas abrogated cyclin D1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	cyclin D1	Homo sapiens	137-146	
12242656-15	2002	In the presence of LY294002, cell-cycle arrest in G0/G1 was observed, p27(Kip1) protein expression was up-regulated whereas the expression of both Skp2 and cyclin D1 dramatically diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin D1	Homo sapiens	156-165	
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D1	Homo sapiens	163-172	
10927622-4	2000	Here we show that inhibition of PI3-K by LY294002 decreases the half-life of the 4.5 kb cyclin D1 mRNA species.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	cyclin D1	Homo sapiens	88-97	
32722075-11	2020	The results suggested that the synergistic cytotoxic effect of LY and TAM is achieved by the induction of apoptosis and cell cycle arrest through cyclin D1, pAKT, caspases, and Bcl-2 signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-65	cyclin D1	Homo sapiens	146-155	
9388270-5	1997	In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	cyclin D1	Homo sapiens	89-98	
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	cyclin D1	Homo sapiens	60-69	
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	cyclin D1	Homo sapiens	225-234	
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	cyclin D1	Homo sapiens	204-212