PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26492523-11 2016 Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 C-C motif chemokine ligand 2 Homo sapiens 77-82 30061946-10 2018 PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 C-C motif chemokine ligand 2 Homo sapiens 120-124 24958127-7 2015 Furthermore, the treatment with LY294002 (50 mumol/L) and Wortmannin (10nmol/L), inhibitors of phosphatidylinositol 3-kinase (PI3K), significantly decreased the amplified VEGF(120) secretion by 29% (p < 0.01) and 28% (p < 0.01) relative to the cells stimulated by ghrelin alone, respectively, whereas these inhibitors had no effects on increased MCP-1 release. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 C-C motif chemokine ligand 2 Homo sapiens 352-357 23831464-7 2013 Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 C-C motif chemokine ligand 2 Homo sapiens 147-151 19166999-7 2009 We found the increase in MCP-1 and CCR2 levels by visfatin were negated by LY294002 and BAY11-7085, but not with U0126, suggesting the crucial role of PI3Kinase and NF-kappaB pathways in visfatin induced MCP-1 and its autocrine regulation via the CCR2 receptor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 C-C motif chemokine ligand 2 Homo sapiens 25-30 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 92-100 C-C motif chemokine ligand 2 Homo sapiens 29-33 19866475-10 2010 The addition of a PI3K/AKT inhibitor Ly294002 reversed the CCL2 protection and was additive to docetaxel-induced toxicity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 C-C motif chemokine ligand 2 Homo sapiens 59-63 22561121-6 2012 SP600125, PD98059, and LY294002 inhibited the induction of at least CCL2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 C-C motif chemokine ligand 2 Homo sapiens 68-72 14960322-0 2004 LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-52 18611860-6 2008 Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 C-C motif chemokine ligand 2 Homo sapiens 158-162 18611860-6 2008 Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 C-C motif chemokine ligand 2 Homo sapiens 158-162 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 C-C motif chemokine ligand 2 Homo sapiens 107-147 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 C-C motif chemokine ligand 2 Homo sapiens 161-165 15607817-10 2005 In contrast, LY294002 had no effect on C3a-induced RANTES/CCL5 production but blocked MCP-1/CCL2 generation by 83.7+/-1.5%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 C-C motif chemokine ligand 2 Homo sapiens 86-91 15607817-10 2005 In contrast, LY294002 had no effect on C3a-induced RANTES/CCL5 production but blocked MCP-1/CCL2 generation by 83.7+/-1.5%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 C-C motif chemokine ligand 2 Homo sapiens 92-96 15161854-6 2004 Ly294002, a specific inhibitor of PI3K, resulted in time- and dose-dependent blockade of MCP-1 mRNA expression and protein production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 C-C motif chemokine ligand 2 Homo sapiens 89-94 18611860-5 2008 Both cell survival and survivin expression were stunted in CCL2-stimulated PC3 cells when treated either with the phosphatidylinositol 3-kinase inhibitor LY294002 (2 microm) or the Akt-specific inhibitor-X (Akti-X; 2.5 microm). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 154-162 C-C motif chemokine ligand 2 Homo sapiens 59-63 14960322-1 2004 The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 C-C motif chemokine ligand 2 Homo sapiens 107-141 14960322-6 2004 These results suggest that LY29 inhibits MCP-1 expression at least in part via suppression of NF-kappaB, independent of PI3K, and the structure of LY29 and LY30 may be a novel template for development of new anti-inflammatory drugs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 27-31 C-C motif chemokine ligand 2 Homo sapiens 41-46 33075233-6 2020 Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 97-105 C-C motif chemokine ligand 2 Homo sapiens 184-188 11278864-4 2001 The activity of PI3Kalpha in purified human monocytes was evident within 30 s. MCP-1-induced monocyte arrest was significantly inhibited both by wortmannin (n = 4; p < 0.01) and LY294002 (n = 4; p < 0.01) with restoration of the rolling phenotype (p < 0.05 for both inhibitors, compared with rolling of control monocytes after MCP-1 treatment). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 181-189 C-C motif chemokine ligand 2 Homo sapiens 79-84