PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29290940-15	2017	LPC-induced apoptosis, and IL-8 expression/secretion was attenuated by LY294002, a PI3K/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-31	
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	106-110	
31684995-10	2019	When we stimulated HCC cells with exogenous IL-8, cell invasion and the levels of integrin beta3, p-PI3K, and p-Akt increased, which could be effectively reversed by adding PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	C-X-C motif chemokine ligand 8	Homo sapiens	79-84	
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	272-276	
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	17-21	
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	100-104	
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	100-104	
31636329-8	2019	The reduced corticosteroid responsiveness may be mediated by glycolytic reprogramming, specifically glycolysis-associated PI3K signaling, as PI3K inhibitor LY294002 restored the sensitivity of CXCL8 secretion to corticosteroids in A549 Rho-0 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	193-198	
29908644-12	2018	Concomitantly, LY294002 inhibited CdCl2-induced IL-8 in JEG-3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	48-52	
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	187-191	
27588140-6	2016	Furthermore, IL-8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	C-X-C motif chemokine ligand 8	Homo sapiens	181-185	
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	90-94	
27740938-10	2016	LY294002 attenuated the 7-KC-induced apoptosis and IL-8 mRNA expression of endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	51-55	
25058399-10	2014	LY294002, a PI3K inhibitor, inhibited HPV-16 oncoprotein-induced activation of Akt, P70S6K, and P85S6K, expression of HIF-1alpha, VEGF, and IL-8, and in vitro angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	140-144	
26121010-5	2015	The effect of leptin on IL-8 could visibly abolished by the inhibitor of PI3K LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	24-28	
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	164-168	
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	200-204	
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	38-42	
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	214-218	
23403077-8	2013	The growth of the tumor spheres could also be reduced by the CXCR2 specific inhibitor SB225002 or the PI3K/AKT inhibitor LY294002, indicating that the endogenously produced CXCL8 plays an autocrine role in the growth of the tumor spheres.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	173-178	
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	C-X-C motif chemokine ligand 8	Homo sapiens	119-123	
22610073-11	2012	Further, IL-8-promoted migration and invasion could be abolished by either the application of the phosphoinositide-3-kinase inhibitor LY294002 or the knock down of AKT expression by using small-interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	9-13	
22420994-10	2012	Also, LY294002, an inhibitor of the Akt/PI3K pathway, abrogated the MA-mediated induction of IL-6 and IL-8 by 77.9 +- 6.6% and 81.4 +- 2.6%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	102-106	
20050188-10	2009	BK-induced IL-8 release was attenuated by inhibitors of phospholipase C (U73122), p38 (SB203580), JNK (SP600125), ERK 1/2 (PD98059) MAPKs, phosphoinositide 3-kinase (LY294002), NF-kappaB (BAY-117085) and by the glucocorticoid dexamethasone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	C-X-C motif chemokine ligand 8	Homo sapiens	11-15	
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	93-98	
21468084-7	2011	Further, the over-expression of LPS-induced IL-8 mRNA in HUVECs was suppressed by a p38 MAPK inhibitor (SB203580, 25 mumol/L) or a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002, 50 mumol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	17-21	
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	22-27	
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	40-44	
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	45-50	
21215400-10	2011	The AcLDL-induced IL-8 production was inhibited by LY294002 and filipin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	18-22	
17130184-9	2007	The inhibitors of PI-3K wortmannin and LY294002 inhibited the chemotaxis and suppressed IL-8-evoked dephosphorylation and rephosphorylation of cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92	
17786963-5	2008	The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	C-X-C motif chemokine ligand 8	Homo sapiens	16-20	
17606477-6	2007	LY294002 and rapamycin each abrogated the IL-8-promoted phosphorylation of rS6 and attenuated the rate of AIPC cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	42-46	
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	51-55	
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	225-229	
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	200-204	
18854173-4	2008	The PAR2-triggered IL-8 release was suppressed by inhibitors of MEK (U0126) or PI3-kinase (LY294002), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	19-23	
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	98-102	
16798838-4	2006	The tyrosine kinase inhibitor Tyrphostin A9, phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 as well as proteasome inhibitors significantly blocked the CXCL8-induced chemotaxis of L1.2 cells and human neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	160-165	
16798838-9	2006	The CXCL8-induced phosphorylation of Cbl was also reduced when cells were pre-treated with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	4-9	
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	131-135	
16761312-7	2006	GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of PI3 K (LY294002) reduced sPLA(2)-induced release of TNF-alpha and CXCL8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	161-166	
11971003-5	2002	Adhesion was blocked approximately 75% by inhibition of the phosphatidylinositol-3 kinase (PI3K) pathway with LY294002, supporting that activation of both MAPK and PI3K may play a role in IL-8-dependent inside-out signals that activate Mac-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	188-192	
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	C-X-C motif chemokine ligand 8	Homo sapiens	58-62	
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-62	
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	225-229	
11971003-6	2002	Activation of MAPK was inhibited in IL-8-stimulated cells in the presence of PI3K inhibitors LY294002 or wortmannin, supporting a model in which PI3K is upstream of MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	36-40	
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142	
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	234-238	
10754327-13	2000	LY294002 blocked IL-8-dependent Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21	
11028544-12	2000	To a lesser extent, incubation of TNFalpha with inhibitors to NF-kappaB (SN50) and PI3K (LY294002) also increased apoptosis and decreased IL-8 production (P < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	138-142	
10754327-14	2000	PD98059 and LY294002 significantly attenuated IL-8 delay of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	46-50	
9096344-3	1997	We demonstrate that phosphatidylinositol-3-kinase (PI3K) activity, as determined by inhibition using wortmannin and LY294002, is required for IL-8-induced cell migration of human neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	C-X-C motif chemokine ligand 8	Homo sapiens	142-146