PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30576222-7	2019	Klotho protein also activated phosphorylation of protein kinase B (AKT), whereas the addition of LY294002, a pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Klotho-protein-induced Nrf2/HO-1 activation and cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	klotho	Homo sapiens	184-190	
30471224-10	2018	The addition of LY294002 inhibited klotho protein downregulation of GRP78, CHOP, caspase-3, caspase-9, and caspase-12 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	klotho	Homo sapiens	35-41	
28771227-6	2017	In addition, Klotho reduced Tac-induced mitochondrial dysfunction and decreased mitochondrial reactive oxygen species production, and these effects were enhanced by blocking PI3K activity with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	klotho	Homo sapiens	13-19	
23437382-7	2013	Further analysis showed that inhibition of PI3K/Akt pathway with specific inhibitor (LY294002) attenuated the promotive effects on cancer growth following interfering with klotho shRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	klotho	Homo sapiens	172-178