PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14516795-6 2003 While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 73-81 mitogen-activated protein kinase 3 Homo sapiens 136-142 14729104-7 2004 The phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY 294002 ((2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) inhibited H(2)O(2)-induced increases in ERK1/2 and PKB phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 80-128 mitogen-activated protein kinase 3 Homo sapiens 170-176 14715711-4 2004 Leptin caused a time- and dose-dependent significant increase in proliferation of HL-1 cells that was inhibited by preincubation with PD98059 and LY294002, suggesting that leptin mediated proliferation via extracellular signal-regulated kinase-1/2- and phosphatidylinositol-3-kinase-dependent signaling pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 146-154 mitogen-activated protein kinase 3 Homo sapiens 206-245 15020266-8 2004 Yet, PI3K inhibitor LY294002 significantly reduced AM80-elicted ERK-1/-2 activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 mitogen-activated protein kinase 3 Homo sapiens 64-72 14516795-6 2003 While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 73-81 mitogen-activated protein kinase 3 Homo sapiens 282-288 11267999-4 2001 Accordingly, ERK1/2 phosphorylation induced by UTP was inhibited by the PI3K inhibitors, wortmannin and LY294002, and the c-src inhibitors, radicicol and PP2, but not by inhibitors of protein kinase C (PKC). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 104-112 mitogen-activated protein kinase 3 Homo sapiens 13-19 12393899-5 2002 Furthermore, cortical neuron apoptosis induced by LY294002-mediated activation of endogenous GSK3beta was blocked by expression of constitutively active MKK1 or by BDNF via stimulation of the endogenous ERK1/2 pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 mitogen-activated protein kinase 3 Homo sapiens 203-209 12444071-12 2002 Western blot analysis confirmed that LY294002 and PD98509 inhibited phosphorylation of Akt and ERK1/ERK2, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 mitogen-activated protein kinase 3 Homo sapiens 95-99 12105209-3 2002 Using phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and Src inhibitor PP2, we show that interleukin (IL)-18-induced ERK1/2 activation is Src kinase-dependent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 mitogen-activated protein kinase 3 Homo sapiens 128-134 11422447-7 2001 The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 133-141 mitogen-activated protein kinase 3 Homo sapiens 29-33 12589789-6 2003 U0126 and LY294002 abolished ERK1/2 and Akt phosphorylation, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10-18 mitogen-activated protein kinase 3 Homo sapiens 29-35 11902114-4 2002 We now report that NMDA receptor activation of Erk1/2 was also blocked by inhibitors of PI 3-kinase (LY 294002, wortmannin). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 101-110 mitogen-activated protein kinase 3 Homo sapiens 47-53 11335710-3 2001 Expression of Deltap85 and incubation with LY294002 both inhibited IL-3-induced activation of Mek, Erk1, and Erk2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 mitogen-activated protein kinase 3 Homo sapiens 99-103 10545192-5 1999 Preincubation with wortmannin and LY294002, two structurally and mechanistically different inhibitors of PI3-K, blocked the VS-mediated increase in MAPK activity and phosphorylation of ERK-1 and ERK-2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 mitogen-activated protein kinase 3 Homo sapiens 185-190 10979966-7 2000 Inhibition of PI3 kinase by selective inhibitor (LY294002) abolished anti-IgE antibody- but not FMLP-induced phosphorylation of MEK1 (MAPK kinase/ERK kinase) and ERKs while inhibiting LTC4 generation as well as histamine release. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 49-57 mitogen-activated protein kinase 3 Homo sapiens 162-166 11226388-12 2001 In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-37 mitogen-activated protein kinase 3 Homo sapiens 193-197 11226388-12 2001 In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-87 mitogen-activated protein kinase 3 Homo sapiens 193-197 10659996-6 1999 Experiments performed with LY294002 indicated that phosphatidylinositol 3-kinase contributed to the HGF-stimulated phosphorylation of Erk1/Erk2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 27-35 mitogen-activated protein kinase 3 Homo sapiens 134-138 10545192-5 1999 Preincubation with wortmannin and LY294002, two structurally and mechanistically different inhibitors of PI3-K, blocked the VS-mediated increase in MAPK activity and phosphorylation of ERK-1 and ERK-2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 mitogen-activated protein kinase 3 Homo sapiens 148-152 10208841-6 1999 LY294002 inhibited ERK1 activation completely and ERK2 activation by 42.9%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 3 Homo sapiens 19-23 10051434-5 1999 We have also shown that phosphoinositide 3-kinase (PI-3K) inhibitors (wortmannin and LY294002) decreased p42/p44 MAPK activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 mitogen-activated protein kinase 3 Homo sapiens 113-117 10066822-6 1999 Treatment with the PI 3-kinase inhibitors wortmannin and LY294002 also blocked MP-induced p42/p44 MAPK, p38, and JNK1 phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 57-65 mitogen-activated protein kinase 3 Homo sapiens 94-102 34875308-15 2022 rHDL-apoE3 also increased the phosphorylation of ERK1/2, AKT, eNOS and p38 MAPK in these cells, while PD98059 and LY294002 inhibited rHDL-apoE3-induced phosphorylation of ERK1/2, AKT and p38 MAPK, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 114-122 mitogen-activated protein kinase 3 Homo sapiens 171-177 9882612-8 1999 This is confirmed here by experiments which showed that PI3K inhibitors (wortmannin and LY294002) reduced the activation of p42/p44 MAPK by PDGF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 88-96 mitogen-activated protein kinase 3 Homo sapiens 132-136 10576564-13 1999 However, pretreatment with wortmannin or LY294002, the inhibitor of phosphatidylinositol 3 kinase (PI-3K), strongly inhibited peptide-stimulated ERK1 activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 mitogen-activated protein kinase 3 Homo sapiens 145-149 33317626-15 2020 Additionally, ELA treatment induced the phosphorylation of AKT and ERK, while the blockade of PI3K/AKT and ERK1/2 pathways with respective inhibitors, LY294002 and U0126, suppressed the action of ELA. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 mitogen-activated protein kinase 3 Homo sapiens 107-113 33258087-9 2021 HMC-EVs-carried miR-24 could target AQP4 to activate the P38 MAPK/ERK1/2/P13K/AKT pathway, and thus promoted the proliferation and migration of SH-SY5Y cells after H/R injury, which were reversed by LY294002 and PD98095. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 199-207 mitogen-activated protein kinase 3 Homo sapiens 66-72 33037575-8 2021 Conversely, U0126 and LY294002, which respectively inhibited phosphorylation of ERK1/2 and Akt, partially prevented S727 phosphorylation, but had limited effects on the level of pY705, suggesting that phosphorylation of Y705 and S727 is regulated via independent mechanisms in FD-treated brains. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 22-30 mitogen-activated protein kinase 3 Homo sapiens 80-86 33334784-8 2020 Moreover, LY294002 treatment increased Erk1/2 activation, decreased cells proliferation and cells viability while activation of Akt by insulin led to an increase in cells survival and cells division. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10-18 mitogen-activated protein kinase 3 Homo sapiens 39-45 32392915-11 2020 Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 56-64 mitogen-activated protein kinase 3 Homo sapiens 177-183 32395075-11 2020 Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 56-64 mitogen-activated protein kinase 3 Homo sapiens 177-183 32630394-8 2020 Further, the use of the inhibitors PD98059 and LY294002 also showed that Erk1/2 and Akt signaling pathways were involved in the neuroprotection mediated by ESC. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 47-55 mitogen-activated protein kinase 3 Homo sapiens 73-79 29766336-5 2018 PI3-kinase and MAPK/ERK1/2 were inhibited using LY294002, and PD98059. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 mitogen-activated protein kinase 3 Homo sapiens 20-26 32318240-7 2020 Following the addition of LY294002, the levels of p-AKT, p-ERK1/2, and p-NF-kappaB decreased significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 mitogen-activated protein kinase 3 Homo sapiens 59-65 30409306-5 2018 Knock down of CD44v4/CD44v6 (by siRNA) or inactivation of MAPK/PI3K pathways using specific PD98059/LY294002 was achieved for in vitro analysis of chemoresistance and invasion/migration. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 100-108 mitogen-activated protein kinase 3 Homo sapiens 58-62 30745840-9 2019 Moreover, overexpression of RRM2 failed to increase the expression of cyclin B1, cyclin D1, and N-cadherin when phosphorylation of AKT and ERK1/2 was suppressed by LY294002 or PD98059. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 164-172 mitogen-activated protein kinase 3 Homo sapiens 139-145 29928334-8 2018 The use of LY294002, a PI3K inhibitor, was able to suppress the activation of Akt and extracellular signal-regulated kinase 1/2, attenuated the migratory and invasive capacities of resistant cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 11-19 mitogen-activated protein kinase 3 Homo sapiens 86-127 29461611-5 2018 Finally, Western blot was used to detect the expressions of Akt and extracellular regulated protein kinases 1/2 (Erk1/2) signal pathway-associated proteins after nucleus pulposus cells were treated with LY294002, the phosphatidylinositol 3-kinase (PI3K) inhibitor, and PD98059, the extracellular regulated protein kinases (MEK) inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 203-211 mitogen-activated protein kinase 3 Homo sapiens 68-111 29319206-8 2018 Furthermore, pretreatment of cells with LY294002 (an AKT inhibitor) and U0126 (ERK1/2 inhibitor) revealed that ERK1/2 activity is also involved in BP-mediated signal transduction in HTR8/SVneo cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 40-48 mitogen-activated protein kinase 3 Homo sapiens 111-117 29461611-5 2018 Finally, Western blot was used to detect the expressions of Akt and extracellular regulated protein kinases 1/2 (Erk1/2) signal pathway-associated proteins after nucleus pulposus cells were treated with LY294002, the phosphatidylinositol 3-kinase (PI3K) inhibitor, and PD98059, the extracellular regulated protein kinases (MEK) inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 203-211 mitogen-activated protein kinase 3 Homo sapiens 113-119 29248464-10 2018 Pre-treatment of cells with selective inhibitors of AKT (LY294002) and ERK1/2 (U0126) revealed that the AKT and ERK1/2 signaling pathways regulated by DA displayed cross-talk in HTR8/SVneo cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 57-65 mitogen-activated protein kinase 3 Homo sapiens 112-118 28833753-7 2017 As expected, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the MAPK inhibitor U0126 inhibited Lf-induced phosphorylation of Akt1 and ERK1/2, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 64-72 mitogen-activated protein kinase 3 Homo sapiens 151-157 28940899-9 2017 ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and Akt, respectively, which in turn reduced the LIPUS-induced proliferation of hAD-MSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 mitogen-activated protein kinase 3 Homo sapiens 110-116 28103512-6 2017 PoFUT1 increased the phosphorylation of ERK1/2, p38 MAPK, and PI3K/Akt, while inhibitors of ERK1/2(PD98059), p38 MAPK(SB203580), and PI3K (LY294002) prevented ERK1/2, p38 MAPK, and Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 139-147 mitogen-activated protein kinase 3 Homo sapiens 40-46 28983584-10 2017 Furthermore, the application of LY294002 prior to incubation with DRSAb eliminated the activation of ERK1/2, whereas the use of PD98059 failed to attenuate the effect of DRSAb on PI3K/AKT activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 mitogen-activated protein kinase 3 Homo sapiens 101-107 25917210-10 2015 However, inhibitors of PI3K/AKT and ERK1/2 (LY294002 or U0126) not only suppressed geraniin-induced nuclear translocation of Nrf2 but also abolished the expression of HO-1, NQO1 and GSH. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 mitogen-activated protein kinase 3 Homo sapiens 36-42 27400655-6 2017 Moreover, PD 98059, LY294002 and Bay 117082, which respectively inhibited the histamine and 4-methylhistamine induced phosphorylation of ERK1/2, Akt and NFkappaB-p65 respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 mitogen-activated protein kinase 3 Homo sapiens 137-143 28185818-6 2017 Further study disclosed that AF enhanced the phosphorylation of PI3K, Akt and ERK1/2 down-regulated by MPP+ in SH-SY5Y cells, the effect of which could be blocked by LY294002, the inhibitor of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 166-174 mitogen-activated protein kinase 3 Homo sapiens 78-84 27171670-9 2017 In addition, the phosphorylation of AKT and ERK1/2 was suppressed by LY294002 and U0126 in JEG-3 cells treated with chrysophanol, whereas, the AKT protein was activated by pre-treatment of JEG-3 cells with U0126. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 mitogen-activated protein kinase 3 Homo sapiens 44-50 27035160-8 2016 Inhibition of PI3-kinase, ERK-1/2, and p38 kinase with LY294002, PD98059, and SB203580, respectively, in the presence of SAL suppressed the metastatic capacity by reducing MMP-2 expression, as determined by gelatin zymography. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 mitogen-activated protein kinase 3 Homo sapiens 26-33 26915319-7 2016 Luteolin, LY294002 (an inhibitor of Akt signaling) and PD98059 (an inhibitor of Erk1/2 signaling) could inhibit the expression of p-Akt and p-Erk1/2 respectively in MCF-7 cells induced by EGF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10-18 mitogen-activated protein kinase 3 Homo sapiens 142-148 26234766-10 2016 Both Snail and MT1-MMP expressions in fibroblasts and cellular invasive activities in 3D collagen induced by PDGF-D were inhibited by LY294002, SP600125, and U1026, the inhibitors of PI3K, JNK, and ERK1/2 signaling pathways, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 134-142 mitogen-activated protein kinase 3 Homo sapiens 198-204 28197636-7 2017 Inhibitors of the PI3K-Akt and ERK1/2 pathways, LY294002 and U0126, significantly suppressed the EMT phenotype. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 mitogen-activated protein kinase 3 Homo sapiens 31-37 27702388-10 2017 Moreover, AG1478, LY294002, and U0126 significantly decreased p-EGFR, p-AKT, and p-ERK1/2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18-26 mitogen-activated protein kinase 3 Homo sapiens 83-89 27208795-5 2016 AgRP-stimulated ERK1/2 phosphorylation through MC3R was abolished by protein kinase A (PKA) inhibitor H-89 but not Rp-cAMPS, whereas AgRP-initiated ERK1/2 activation through MC4R was inhibited by phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 259-267 mitogen-activated protein kinase 3 Homo sapiens 148-154 26940012-8 2016 Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 mitogen-activated protein kinase 3 Homo sapiens 101-107 25146167-8 2014 Treatment of the human meningioma cell line HBL-52 with the PI3K inhibitor LY294002 resulted in reduction of p-AKT, p-p70S6K and p-ERK1/2 protein levels. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 mitogen-activated protein kinase 3 Homo sapiens 131-137 25748730-6 2015 Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 mitogen-activated protein kinase 3 Homo sapiens 112-118 26138882-7 2015 Our data also showed that the mineralcorticoid receptor (MR) antagonist spironolactone, ERK1/2 inhibitor PD98059 and PKC inhibitor GF109203X could attenuate the down-regulation of Cx43 expression in Aldo-induced MC proliferation; however, the PI3K inhibitor LY294002 could block MC proliferation without affecting Cx43 expression at either the mRNA or protein level. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 258-266 mitogen-activated protein kinase 3 Homo sapiens 88-94 24012499-9 2013 This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 mitogen-activated protein kinase 3 Homo sapiens 149-155 25068805-11 2014 Inhibition of AKT in Ishikawa cells with LY294002 resulted in a significant reduction in the levels of phospho-ERK1/2, whereas inhibition of ERK1/2 with PD98059 exerted no effects on AKT activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 mitogen-activated protein kinase 3 Homo sapiens 111-117 23604952-6 2014 PRPr led to the phosphorylation of Erk1/2 and Akt in HUVECs, and the induction of proliferation and migration by PRPr was suppressed by PRPr inhibitors PD98059 and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 164-172 mitogen-activated protein kinase 3 Homo sapiens 35-41 24441870-7 2014 In addition, TNF-alpha-induced p42/p44 MAPK phosphorylation was reduced by AG1296 or LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 mitogen-activated protein kinase 3 Homo sapiens 39-43 24441870-8 2014 On the other hand, TNF-alpha could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 153-161 mitogen-activated protein kinase 3 Homo sapiens 58-62 24488601-6 2014 Pharmacological inhibition of mitogen-activated protein kinase 1 (ERK1/2), CaMKII, and Trk (with U0126, KN93, or K252a, respectively) partially attenuated the stimulatory effect of DISS on phospho-CREB and BDNF expression; however, it was not inhibited by pharmacological inhibition of PKA or PI3K (with H89 and LY294002, respectively). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 312-320 mitogen-activated protein kinase 3 Homo sapiens 66-72 24805814-6 2014 When the phosphorylation of ERK1/2 and PI3K/AKT was inhibited by PD98059 and LY294002, respectively, the decreased proliferation and invasion induced by BMP9 knock down were eliminated. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 77-85 mitogen-activated protein kinase 3 Homo sapiens 28-34 24451985-8 2014 The addition of LY294002, a PI3K inhibitor, decreased VEGF-induced phosphorylation of ERK1/2 and AKT1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 mitogen-activated protein kinase 3 Homo sapiens 86-92 24451985-9 2014 Furthermore, VEGF significantly stimulated proliferation and migration of pTr cells, but these effects were blocked by SB203580, U0126, rapamycin, and LY294002, which inhibit p38 MAPK, ERK1/2, mTOR, and PI3K, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 mitogen-activated protein kinase 3 Homo sapiens 185-191 24520418-8 2014 Also, the PI3K specific inhibitor (LY294002) abolished CSF2-induced increases in p-ERK1/2 and p-MTOR proteins, as well as CSF2-induced phosphorylation of AKT1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 mitogen-activated protein kinase 3 Homo sapiens 83-89 24012499-9 2013 This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 mitogen-activated protein kinase 3 Homo sapiens 213-219 24200059-9 2013 Western blotting showed that the expressions of ZO-1, occludin and claudin-5 were significantly reduced after 2.5 mumol/L lead treatment (P<0.05); the phosphorylation levels of ERK1/2, JNK, p38, AKT473 and AKT308 were elevated significantly (P<0.05); ERK1/2 inhibitor PD98059 and PI3K inhibitor LY294002 reversed the lead effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 301-309 mitogen-activated protein kinase 3 Homo sapiens 180-186 23161148-10 2013 The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 mitogen-activated protein kinase 3 Homo sapiens 34-40 21544845-9 2012 Furthermore, pretreatment with gefitinib and the pharmacological inhibitors of PI3K (LY294002) and ERK1/2 (PD98059) prevented cigarette smoke-mediated Akt and ERK1/2 phosphorylation responses, HIF-1alpha production, HIF-1 activity and MUC5AC expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 mitogen-activated protein kinase 3 Homo sapiens 159-165 21769475-6 2012 Furthermore, the high expression of IL-15 induced by IL-6 was down-regulated while MAPKs-ERK1/2 and PI3K-AKT signaling pathways were, respectively, blocked by PD98059 and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 171-179 mitogen-activated protein kinase 3 Homo sapiens 89-95 23363008-7 2013 The employment of protein kinase inhibitors LY294002, SB203580, SP600125, and U0126 revealed that PI3K/Akt signaling pathway interplayed with MAPK signaling pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 mitogen-activated protein kinase 3 Homo sapiens 142-146 22925659-6 2012 LY294002 and U0126, inhibitors of PI3K and ERK1/2, respectively, reduced H2O2 generation in concentration-dependent manners. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 3 Homo sapiens 43-49 21904903-5 2011 Signaling transduction inhibitors, LY294002 and PD98059, were used to block PI3K/Akt and MAPK/ERK1/2 signaling pathways, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 mitogen-activated protein kinase 3 Homo sapiens 94-100 19882665-5 2010 Moreover, the effect of Sox2 on NPC self-renewal is completely inhibited by AG1478, a specific inhibitor for Egfr; it is also inhibited by LY294002 and U0126, selective antagonists for phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (Erk1/2), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 139-147 mitogen-activated protein kinase 3 Homo sapiens 265-271 21536288-7 2011 The mitogenic effect of MCP-3 appeared to be dependent on ERK1/2 MAPK and PI3K signaling pathway activation, as demonstrated by the reduction of MCP-3-induced CASMC proliferation observed after the treatment of cells with U0126 (1 muM) and LY-294002 (5muM), selective inhibitors of ERK 1/2 and PI3K activation, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 240-249 mitogen-activated protein kinase 3 Homo sapiens 58-64 21215800-6 2011 ERK1/2 activation was unaffected by the phosphatidylinositol 3-kinase inhibitor LY-294002, but was sensitive to inhibitors of Src kinase, phospholipase C and Gbetagamma subunit signalling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 80-89 mitogen-activated protein kinase 3 Homo sapiens 0-6 20855443-6 2010 Blockage of ERK1/2 or AKT activation by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126; MKK1/2 inhibitor) or 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002; phosphatidyl inositol 3-kinase inhibitor), respectively, decreased the gemcitabine-induced Rad51 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 172-180 mitogen-activated protein kinase 3 Homo sapiens 12-18 21948550-9 2011 The authors then determined cross-talk between PI 3-kinase and extracellular signal-regulated kinase (ERK)1/2; blocking of ERK1/2 activation by LY294002 indicated that in hCECs ERK1/2 works as a downstream effector to PI 3-kinase for cell proliferation induced by FGF-2, whereas the ERK1/2 pathway in rCECs is parallel to the PI 3-kinase pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 mitogen-activated protein kinase 3 Homo sapiens 123-129 21948550-9 2011 The authors then determined cross-talk between PI 3-kinase and extracellular signal-regulated kinase (ERK)1/2; blocking of ERK1/2 activation by LY294002 indicated that in hCECs ERK1/2 works as a downstream effector to PI 3-kinase for cell proliferation induced by FGF-2, whereas the ERK1/2 pathway in rCECs is parallel to the PI 3-kinase pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 mitogen-activated protein kinase 3 Homo sapiens 177-183 21948550-9 2011 The authors then determined cross-talk between PI 3-kinase and extracellular signal-regulated kinase (ERK)1/2; blocking of ERK1/2 activation by LY294002 indicated that in hCECs ERK1/2 works as a downstream effector to PI 3-kinase for cell proliferation induced by FGF-2, whereas the ERK1/2 pathway in rCECs is parallel to the PI 3-kinase pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 mitogen-activated protein kinase 3 Homo sapiens 177-183 20506505-7 2010 Inhibitors of PI3K (LY294002 and Wortmannin) prevented the phosphorylation of ERK1/2, p38 MAPK, and Akt PI3K). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 mitogen-activated protein kinase 3 Homo sapiens 78-84 20135719-9 2010 Inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway by the PI3K inhibitor, LY294002, markedly suppressed HGF-stimulated invasion of both CCA cell lines, and inhibition of the ERK pathway by U0126 suppressed HGF-induced invasion of the KKU-M213 cell line but had a moderate effect on HuCCA-1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 mitogen-activated protein kinase 3 Homo sapiens 186-189 19443725-7 2009 In contrast, blocking PI3-K activation with LY294002 (50 microM) eliminated EGF-induced GSK-3 inhibition and Erk1/2 phosphorylation as well as increases in proliferation and migration. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 mitogen-activated protein kinase 3 Homo sapiens 109-115 19892399-7 2009 PD98059 (a MEK1/2 inhibitor) at 20microM and LY294002 (a PI3K inhibitor) at 5microM attenuated FGF2- and VEGF-induced phosphorylation of ERK1/2 and AKT1, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 mitogen-activated protein kinase 3 Homo sapiens 137-143 18941890-11 2009 Inhibition of Erk1/2 by U0126 (10 microM) decreased p-ser118-ERalpha by 51.7 +/- 8.5% and decreased p-ser167-ERalpha by 41.9 +/- 16.9% whereas inhibition of Akt by LY294002 (20 microM) and wortmannin (500 nM) or by siRNA knock-down, had no effect on p-ser167-ERalpha expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 164-172 mitogen-activated protein kinase 3 Homo sapiens 14-20 19711359-5 2009 In addition, LY294002, a PI3-kinase inhibitor; SH-6, an Akt inhibitor; and PDTC, a nuclear factor kappa B (NF-kappaB) inhibitor, but not PD98059, an ERK1/2 inhibitor, abolished the protective effect of BDNF against cell death. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 mitogen-activated protein kinase 3 Homo sapiens 149-155 19428994-8 2009 However, alpha-MSH-induced ERK1/2 activation is abolished by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 128-136 mitogen-activated protein kinase 3 Homo sapiens 27-33 19406941-5 2009 Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 mitogen-activated protein kinase 3 Homo sapiens 97-103 19406941-5 2009 Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 mitogen-activated protein kinase 3 Homo sapiens 97-103 19610136-8 2009 Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 24-32 mitogen-activated protein kinase 3 Homo sapiens 92-98 19328461-8 2009 Three or 24h after exposure to the inhibitors, all the inhibitors downregulated the level of the phosphorylated ERK1/2, of which the inhibitory roles of PD98059, LY294002 and AG490 were more significant. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 162-170 mitogen-activated protein kinase 3 Homo sapiens 112-118 19143758-10 2009 However, TGFbeta and LY294002, a potent inhibitor of PI3-kinase, significantly inhibited phosphorylation of both p85 and ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 21-29 mitogen-activated protein kinase 3 Homo sapiens 121-127 18315925-8 2008 Ly294002 and PD98059 blocked the activation of Akt and ERK1/2 respond to BDNF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 mitogen-activated protein kinase 3 Homo sapiens 55-61 18425342-9 2008 Both rapamycin and Ly294002 enhanced cisplatin-induced acti-vation of ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 mitogen-activated protein kinase 3 Homo sapiens 70-76 18341625-3 2008 Also, the phosphorylation of ERK1/2 and Akt was detected by Western blotting, and specific inhibitors of mitogen-activated protein kinase (MAPK) (PD98059; 40 microm) and phosphatidylinositol 3-kinase (PI3-K, LY294002; 40 microm) were used to evaluate the role of these signalling pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 208-216 mitogen-activated protein kinase 3 Homo sapiens 29-35 16884765-6 2006 High concentrations of SDF-1alpha activated Akt and ERK1/2 pathways in both cell lines in a dose-dependent manner, which was primarily inhibited by LY294002 for pAkt and by PD98059 for pERK 1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 148-156 mitogen-activated protein kinase 3 Homo sapiens 52-58 17539658-8 2007 EGCG also decreased the phosphorylation of Akt and extracellular signal-regulated kinase 1/2 that were demonstrated as selected downstream HRG-beta1-responsive kinases required for FAS expression using dominant-negative Akt, PI3K inhibitors (LY294002 and wortmannin), or MEK inhibitor (PD98059). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 242-250 mitogen-activated protein kinase 3 Homo sapiens 51-92 17473185-9 2007 Blocking extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphoinositide-3-kinase by PD98059 and LY294002, respectively, abolished 16 E6- and E7-induced HIF-1 alpha and VEGF expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 mitogen-activated protein kinase 3 Homo sapiens 52-59 17068339-6 2006 We found that insulin-induced ERK1/2 and Akt kinase activities were completely abolished 10 min after inhibition of the corresponding upstream kinases with PD98059 and LY294002, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 168-176 mitogen-activated protein kinase 3 Homo sapiens 30-36 17234779-4 2007 Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 64-72 mitogen-activated protein kinase 3 Homo sapiens 202-208 16406609-3 2006 Here, we report that two structurally distinct PI3K inhibitors, wortmannin and LY294002, inhibited insulin-induced activation of ERK1/2 but had no effect on EGF-induced activation of ERK1/2 in hepatocellular carcinoma BEL-7402 and SMMC-7721 cells, breast cancer MCF-7 cells, and prostate cancer LNCaP cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 79-87 mitogen-activated protein kinase 3 Homo sapiens 129-135 15833899-7 2005 Furthermore, inactivation of PI3K with LY294002 [2-(4morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] blocked suramin-induced RPTC outgrowth, scattering, and proliferation, whereas blockade of ERK1/2 had no effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 mitogen-activated protein kinase 3 Homo sapiens 189-195 16128807-3 2005 In three different hemopoietic cell lines stimulated with cytokines, and in HEK293 cells, stimulated with serum, either wortmannin or LY294002, but never both, could partially block phosphorylation of Erks. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 134-142 mitogen-activated protein kinase 3 Homo sapiens 201-205 16394177-3 2006 The BK-induced ERK1/2 phosphorylation was completely blocked by PD98059 (an inhibitor of the mitogen-activated protein kinase kinase (MAPKK or MEK)) and by LY294002 (an inhibitor of phosphoinositide 3-kinase (PI3K)), and was reduced by GF109203X (an inhibitor of both novel and conventional PKCs); Go6976, a conventional PKCs inhibitor, did not have any effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 156-164 mitogen-activated protein kinase 3 Homo sapiens 15-21 16135959-10 2005 The enhanced MMP-9 levels induced by peptidoglycan was attenuated by inhibitors of p38 mitogen-activated protein kinases (MAPK), (SB202190, 25 microM) and ERK1/2 (PD98059, 25 microM) and inhibitors of Src Tyrosine kinase (PP2, 5 microM) and PI3-K (LY294002, 25 microM). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 248-256 mitogen-activated protein kinase 3 Homo sapiens 122-126 15857748-4 2005 Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked (approximately 90%) by H89 (PKA inhibitor) and LY294002 but not by Wortmannin (PI3-K inhibitors), 4-OH-tamoxifen, ICI182,780 or SB203580 (p38 MAPK inhibitor); PD98059 (ERK1/2 inhibitor) partially (approximately 30%) blocked the FSH-mediated effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 129-137 mitogen-activated protein kinase 3 Homo sapiens 250-256 15947112-8 2005 Further, FSH and LH significantly increased activities of various kinases at 5-10 min, and pre-treatments with LY294002 (an inhibitor of PI3K) or PD98059 (an inhibitor of ERK1/2) partially blocked the gonadotropin-induced up-regulation of EGFR in IOSE-80PC cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 111-119 mitogen-activated protein kinase 3 Homo sapiens 171-177 15934945-4 2005 U0126, a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, both inhibited FGF2-induced BrdU incorporation, suggesting that the extracellular signal-regulated kinase1/2 (ERK1/2) and PI3K pathways are required for FGF2-induced NP cell proliferation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 77-85 mitogen-activated protein kinase 3 Homo sapiens 247-253 15715661-5 2005 Treatment with different inhibitors including rapamycin, wortmannin, LY294002, and U0126, and their combinations, indicated that phosphorylation of p70S6K and GSK-3beta is regulated by rapamycin-dependent, PI3K and MAPK pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 mitogen-activated protein kinase 3 Homo sapiens 215-219 16036314-12 2005 Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by PI-3K (phosphatidylinositol 3-kinase) inhibitors wortmannin and LY294002, but not the MEK (MAPK kinase) inhibitor UO126. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 170-178 mitogen-activated protein kinase 3 Homo sapiens 197-201 15947481-9 2005 Furthermore, ERK1/2 activation by WKYMVm was completely inhibited by pretreatment with the PI3-kinase inhibitor LY294002, but not by the PKC inhibitor Ro-31-8220. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 mitogen-activated protein kinase 3 Homo sapiens 13-19 15313431-4 2004 We found that C5a-induced, time-dependent (1) ERK1/2 phosphorylation was markedly diminished by PTX, U73122, P13K inhibitors wortmannin and LY294002 and ERK1/2 inhibitor PD98059; (2) Akt phosphorylation was also attenuated by the above inhibitors except PD98059; (3) p38 MAPK phosphorylation was only affected by PTX. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 140-148 mitogen-activated protein kinase 3 Homo sapiens 46-52