PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30902657-0	2019	Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I. Farnesoid X receptor (FXR) agonists play important regulatory roles in bile acid, lipid and glucose metabolism in vitro and in vivo.	GW 4064	29-35	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	10-20	
30920307-15	2019	These findings provide a clinical research direction for the prevention of liver disease in patients with SBS.NEW & NOTEWORTHY This study assessed the impact of treatment with GW4064, a farnesoid X receptor agonist, on the development of short bowel resection (SBR) associated with liver disease in a rat model of SBR.	GW 4064	180-186	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	200-210	
30428773-0	2019	Farnesoid X Receptor Agonist GW4064 Inhibits Aromatase and ERbeta Expression in Human Endometriotic Stromal Cells.	GW 4064	29-35	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	10-20	
30902657-0	2019	Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I. Farnesoid X receptor (FXR) agonists play important regulatory roles in bile acid, lipid and glucose metabolism in vitro and in vivo.	GW 4064	29-35	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	142-152	
23101941-0	2012	Unbinding pathways of GW4064 from human farnesoid X receptor as revealed by molecular dynamics simulations.	GW 4064	22-28	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	50-60	
28787755-1	2017	GW4064 is a small molecule known to be an agonist of the nuclear farnesoid X receptor (FXR).	GW 4064	0-6	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	75-85	
25934227-0	2015	Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.	GW 4064	17-23	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	65-75	
25400456-0	2014	GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells.	GW 4064	0-6	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	20-30	
25725071-0	2015	GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.	GW 4064	0-6	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	32-42	
25499883-0	2015	Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.	GW 4064	32-38	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	52-62	
23878601-4	2013	Interestingly, activation of the farnesoid X receptor (FXR) through the bile acid ursodeoxycholic acid (UDCA) or synthetic FXR agonists, such as GW4064, can increase DDAH1 expression.	GW 4064	145-151	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	43-53	
22579649-0	2012	Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand.	GW 4064	94-100	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	114-124	
22583617-3	2012	We previously found that compounds based on GW4064, a representative farnesoid X receptor (FXR) agonist, enhanced E297G BSEP transport activity.	GW 4064	44-50	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	79-89	
18755856-1	2008	The farnesoid X receptor (FXR, NR1H4) belongs to the nuclear receptor superfamily and is activated by bile acids such as chenodeoxycholic acid, or synthetic ligands such as GW4064.	GW 4064	173-179	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	14-24	
21660973-0	2011	A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys.	GW 4064	89-95	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	69-79	
21499302-4	2011	In this study, we show that activation of farnesoid X receptor (FXR), by the primary bile acid chenodeoxycholic acid (CDCA) or the synthetic agonist GW4064, inhibited growth of Tam-resistant breast cancer cells (termed MCF-7 TR1), which was used as an in vitro model of acquired Tam resistance.	GW 4064	149-155	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	52-62	
21319191-8	2011	Treatment of mouse or human hepatocytes with a farnesoid X receptor (FXR) agonist GW4064 or bile acids induced hepatic Abcg5/g8 expression.	GW 4064	82-88	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	57-67	
19410460-0	2009	Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.	GW 4064	68-74	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	43-53	
15692145-8	2005	Treatment of Huh7 cells with CDCA or the synthetic farnesoid X receptor (FXR) agonist GW4064 decreased mRNA and protein levels and also nuclear binding activity of HNF-4 alpha.	GW 4064	86-92	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	61-71