PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26574146-7	2015	GW4064, a farnesoid X receptor agonist, decreases hepatic CYP2D6 expression and activity while increasing small heterodimer partner expression and its recruitment to the CYP2D6 promoter.	GW 4064	0-6	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	58-64	
25926433-7	2015	In CYP2D6-humanized transgenic mice, GW4064 decreased hepatic CYP2D6 expression and activity (by 2-fold) while increasing SHP expression (by 2-fold) and SHP recruitment to the CYP2D6 promoter.	GW 4064	37-43	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	3-9	
25926433-7	2015	In CYP2D6-humanized transgenic mice, GW4064 decreased hepatic CYP2D6 expression and activity (by 2-fold) while increasing SHP expression (by 2-fold) and SHP recruitment to the CYP2D6 promoter.	GW 4064	37-43	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	62-68	
25926433-7	2015	In CYP2D6-humanized transgenic mice, GW4064 decreased hepatic CYP2D6 expression and activity (by 2-fold) while increasing SHP expression (by 2-fold) and SHP recruitment to the CYP2D6 promoter.	GW 4064	37-43	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	62-68	
25926433-8	2015	CYP2D6 repression by GW4064 was abrogated in Shp(-/-);CYP2D6 mice, indicating a critical role of SHP in CYP2D6 regulation by GW4064.	GW 4064	21-27	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6	
25926433-8	2015	CYP2D6 repression by GW4064 was abrogated in Shp(-/-);CYP2D6 mice, indicating a critical role of SHP in CYP2D6 regulation by GW4064.	GW 4064	21-27	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60	
25926433-8	2015	CYP2D6 repression by GW4064 was abrogated in Shp(-/-);CYP2D6 mice, indicating a critical role of SHP in CYP2D6 regulation by GW4064.	GW 4064	21-27	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60	
25926433-8	2015	CYP2D6 repression by GW4064 was abrogated in Shp(-/-);CYP2D6 mice, indicating a critical role of SHP in CYP2D6 regulation by GW4064.	GW 4064	125-131	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6	
25926433-8	2015	CYP2D6 repression by GW4064 was abrogated in Shp(-/-);CYP2D6 mice, indicating a critical role of SHP in CYP2D6 regulation by GW4064.	GW 4064	125-131	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60	
25926433-8	2015	CYP2D6 repression by GW4064 was abrogated in Shp(-/-);CYP2D6 mice, indicating a critical role of SHP in CYP2D6 regulation by GW4064.	GW 4064	125-131	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60	
25926433-9	2015	Also, GW4064 decreased CYP2D6 expression (by 2-fold) in primary human hepatocytes, suggesting that the results obtained in CYP2D6-humanized transgenic mice can be translated to humans.	GW 4064	6-12	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	23-29	
25926433-9	2015	Also, GW4064 decreased CYP2D6 expression (by 2-fold) in primary human hepatocytes, suggesting that the results obtained in CYP2D6-humanized transgenic mice can be translated to humans.	GW 4064	6-12	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	123-129	
25926433-10	2015	This proof of concept study provides evidence for CYP2D6 regulation by an inducer of SHP expression, namely, the FXR agonist GW4064.	GW 4064	125-131	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	50-56	
26574146-7	2015	GW4064, a farnesoid X receptor agonist, decreases hepatic CYP2D6 expression and activity while increasing small heterodimer partner expression and its recruitment to the CYP2D6 promoter.	GW 4064	0-6	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	170-176