PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21924881-5 2013 METHODS AND RESULTS: FXR is expressed in neonatal cardiomyocytes and the treatment with FXR agonists, chenodeoxycholic acid (CDCA), and GW4064, increased the mRNA expression of FXR and its canonical target gene, the small heterodimer partner (SHP), as well as proliferator-activated receptor alpha PPARalpha, acyl-CoA oxidase (AOX) and pyruvate dehydrogenase kinase (PDK-4). GW 4064 136-142 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 21-24 30920307-0 2019 FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection. GW 4064 12-18 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 0-3 30920307-6 2019 After intervention with the FXR agonist GW4064, both the liver histology and serum transaminase activity were improved, which demonstrated the attenuation of SBR-ALD. GW 4064 40-46 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 28-31 30920307-11 2019 This study showed that the FXR agonist GW4064 could correct BA dysmetabolism to alleviate hepatotoxicity in SBR animals. GW 4064 39-45 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 27-30 30920307-14 2019 Concomitantly, FXR activation in the presence of GW4064 decreased BA production by repressing the expression of key synthetases, including CYP7A1, CYP8B1, and CYP27A1. GW 4064 49-55 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 15-18 30139242-6 2018 We found that the FXRagonists GW4064 and INT-747 increased the protein abundance of AT2R and B2R in rat aortic VSMCs.AT2R blockade with PD123319 reversed the effects of FXR agonists on kallikrein activity, B2R, andbradykinin levels. GW 4064 30-36 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 18-21 23124354-4 2013 Here, we demonstrated that treatment with GW4064, a specific FXR agonist, markedly reduced Leydig tumor growth in vivo by inhibiting proliferation and inducing apoptosis. GW 4064 42-48 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 61-64 29235094-3 2018 In the cellular experiments, FXR expression was up-regulated by either lentiviral transduction or GW4064 treatment and down-regulated by either siRNA technology or treatment with guggulsterones. GW 4064 98-104 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 29-32 26710942-7 2016 It was found that the FXR agonists GW4064 and INT-747, in a dose-dependent manner, increased the protein abundance of AT2 R, B2 R and SHP-1 and decreased that of AT1 R. GW 4064 35-41 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 22-25 21924881-5 2013 METHODS AND RESULTS: FXR is expressed in neonatal cardiomyocytes and the treatment with FXR agonists, chenodeoxycholic acid (CDCA), and GW4064, increased the mRNA expression of FXR and its canonical target gene, the small heterodimer partner (SHP), as well as proliferator-activated receptor alpha PPARalpha, acyl-CoA oxidase (AOX) and pyruvate dehydrogenase kinase (PDK-4). GW 4064 136-142 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 88-91 21924881-5 2013 METHODS AND RESULTS: FXR is expressed in neonatal cardiomyocytes and the treatment with FXR agonists, chenodeoxycholic acid (CDCA), and GW4064, increased the mRNA expression of FXR and its canonical target gene, the small heterodimer partner (SHP), as well as proliferator-activated receptor alpha PPARalpha, acyl-CoA oxidase (AOX) and pyruvate dehydrogenase kinase (PDK-4). GW 4064 136-142 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 88-91 17065154-2 2006 By microarray analysis of hepatic genes from female Zucker diabetic fatty (ZDF) rats treated with the FXR agonist GW4064, we have identified dimethylarginine dimethylaminohydrolase-1 (DDAH1) as an FXR target gene. GW 4064 114-120 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 102-105 20026603-5 2010 We found, in rat Leydig tumor cells, R2C, that FXR activation by the primary bile acid chenodeoxycholic acid (CDCA) or a synthetic agonist GW4064, through a SHP-independent mechanism, down-regulates aromatase expression in terms of mRNA, protein levels, and its enzymatic activity. GW 4064 139-145 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 47-50 17065154-2 2006 By microarray analysis of hepatic genes from female Zucker diabetic fatty (ZDF) rats treated with the FXR agonist GW4064, we have identified dimethylarginine dimethylaminohydrolase-1 (DDAH1) as an FXR target gene. GW 4064 114-120 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 197-200 17065154-5 2006 Functional analysis of the putative FXRE demonstrated GW4064 dose-dependent transcriptional activation from the element, and we have demonstrated that the FXRE sequence binds the FXR-RXR heterodimer. GW 4064 54-60 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 36-39 15644430-8 2005 These changes were reproduced by GW4064, a synthetic FXR ligand. GW 4064 33-39 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 53-56 12754200-8 2003 Finally, Fisher rats treated with the synthetic FXR ligand GW4064 clearly show increased transcript levels of both the BACS and BAT mRNA. GW 4064 59-65 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 48-51 14623915-4 2003 We investigated whether the synthetic FXR agonist GW4064 could protect against cholestatic liver damage in rat models of extrahepatic and intrahepatic cholestasis. GW 4064 50-56 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 38-41 34045606-7 2021 Finally, using the synthetic, non-bile acid, FXR-agonist GW4064, we show that some of these effects are mediated through direct or indirect activation of FXR. GW 4064 57-63 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 45-48 34045606-7 2021 Finally, using the synthetic, non-bile acid, FXR-agonist GW4064, we show that some of these effects are mediated through direct or indirect activation of FXR. GW 4064 57-63 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 154-157 11706036-3 2002 MRP2 mRNA levels were induced following treatment of human or rat hepatocytes with either naturally occurring (chenodeoxycholic acid) or synthetic (GW4064) FXR ligands. GW 4064 148-154 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 156-159 32341465-8 2020 Farnesoid X receptor (FXR) inhibitor glycine-beta-muricholic acid or FXR knockdown reversed the downregulation of PepT1 expression by CDCA and GW4064 (another FXR agonist). GW 4064 143-149 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 0-20