PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23313557-7 2013 In Alexander cells, only when they were transfected with FXR+RXR, GW4064 caused up-regulation of SHP and OSTbeta, and a down-regulation of CYP27A1. GW 4064 66-72 retinoid X receptor alpha Homo sapiens 61-64 12519787-4 2003 Using real-time quantitative PCR and cotransfection reporter assays, we demonstrate that the RXR agonist LG100268 antagonizes induction of BSEP expression mediated by endogenous and synthetic FXR ligands, CDCA and GW4064, respectively. GW 4064 214-220 retinoid X receptor alpha Homo sapiens 93-96 16037943-7 2005 In these cells, the FXR pharmacological agonist GW4064 upregulated VPAC1 expression in a dose-dependent manner, and this effect was antagonized by the RXRalpha ligand, 9-cis retinoic acid. GW 4064 48-54 retinoid X receptor alpha Homo sapiens 151-159 22579649-9 2012 Our results suggest that ACR and GW4064 cooperatively inhibit RXRalpha phosphorylation, modulate the expression of FXR-regulated genes, thus resulting in the induction of apoptosis and the inhibition of growth in HCC cells. GW 4064 33-39 retinoid X receptor alpha Homo sapiens 62-70 22800197-12 2012 In LS174T cells, GW4064-induced chemoresistance was seen only after being transfected with FXR+RXR, when BCRP, but not MRP2, was up-regulated. GW 4064 17-23 retinoid X receptor alpha Homo sapiens 95-98 23680185-7 2013 In human hepatoma Alexander cells, with negligible endogenous expression of FXR, GW4064 also protected against cisplatin-induced toxicity, but only if they were previously transfected with FXR/RXR. GW 4064 81-87 retinoid X receptor alpha Homo sapiens 193-196