PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24370186-10	2014	Proliferation and cytoskeletal rearrangement were suppressed by pre-treatment with the ROCK inhibitor Y-27632; additionally, expression of ROCK protein and phosphorylation of LIM kinase and cofilin were decreased by Y-27632, while Rho-GDIa knockdown by targeted siRNA transfection causes opposite effects.	Y 27632	102-109	cofilin 1	Homo sapiens	190-197	
25817589-6	2015	The phosphorylation of cofilin by OPN was suppressed when cells were pretreated with ROCK inhibitor Y27632 by Western blot.	Y 27632	100-106	cofilin 1	Homo sapiens	23-30	
25500336-4	2015	We found that U46619, a thromboxane receptor (TP) agonist, induced the phosphorylation of cofilin, a target of Rho-kinase signaling, and that the cofilin phosphorylation by U46619 was suppressed by Y27632 or fasudil, specific inhibitors of Rho-kinase.	Y 27632	198-204	cofilin 1	Homo sapiens	90-97	
25500336-4	2015	We found that U46619, a thromboxane receptor (TP) agonist, induced the phosphorylation of cofilin, a target of Rho-kinase signaling, and that the cofilin phosphorylation by U46619 was suppressed by Y27632 or fasudil, specific inhibitors of Rho-kinase.	Y 27632	198-204	cofilin 1	Homo sapiens	146-153	
19649725-6	2010	We found that Y-27632 increased both heterotypic and homotypic adhesion, and the expression of E-cadherin; decreased phosphorylated cofilin resulting in actin rearrangement in ESCC cells.	Y 27632	14-21	cofilin 1	Homo sapiens	132-139	
23951242-10	2013	In endothelial cells, LIMK-mediated cofilin phosphorylation after thrombin-stimulation of EGFP- or DsRed2-tagged cofilin transfected cells reduced cofilin aggregate formation, whereas inhibition of cofilin phosphorylation after Rho-kinase inhibitor (Y27632) treatment of endothelial cells promoted formation of cofilin aggregates.	Y 27632	250-256	cofilin 1	Homo sapiens	36-43	
23951242-11	2013	In platelets, cofilin dephosphorylation after thrombin-stimulation and Y27632 treatment led to an increased formation of the cofilin oligomer.	Y 27632	71-77	cofilin 1	Homo sapiens	125-132	
23337538-11	2013	Estrogen-induced phosphorylation of cofilin was inhibited by Y-27632, a specific inhibitor of the Rho-associated protein serine/threonine kinase (ROCK).	Y 27632	61-68	cofilin 1	Homo sapiens	36-43	
21769918-8	2011	Treatment with Y-27632, a specific ROCK inhibitor, we found that dysregulation of ROCK/cofilin pathway decreased p-cofilin expression and induced cell migration.	Y 27632	15-22	cofilin 1	Homo sapiens	87-94	
21769918-8	2011	Treatment with Y-27632, a specific ROCK inhibitor, we found that dysregulation of ROCK/cofilin pathway decreased p-cofilin expression and induced cell migration.	Y 27632	15-22	cofilin 1	Homo sapiens	115-122	
19144696-8	2009	Treatment with Y-27632, an inhibitor of the RhoA effector p160-ROCK, decreased levels of phosphorylated cofilin and reduced stress fiber fluorescence by 22%.	Y 27632	15-22	cofilin 1	Homo sapiens	104-111	
19144696-9	2009	In cells treated with Y-27632 followed by treatment with the cytokine cocktail, stress fiber levels were similar to control cells and cofilin phosphorylation was 55% of control levels.	Y 27632	22-29	cofilin 1	Homo sapiens	134-141	
17321765-7	2007	Pretreatment with the Rho-kinase inhibitor Y-27632 inhibited LIMK-1 phosphorylation, unmasked cofilin dephosphorylation and inhibited the reversible F-actin increase during shape change.	Y 27632	43-50	cofilin 1	Homo sapiens	94-101	
17138966-8	2007	Y-27632 reduced the levels of both active LIMK-1 and inactive cofilin (phospho forms), and expression of a dominant negative LIMK-1 mutant stimulated leading edge protrusiveness.	Y 27632	0-7	cofilin 1	Homo sapiens	62-69	
17138966-9	2007	Furthermore, Y-27632-induced protrusions were partially reversed by overexpression of LIMK-1 to restore cofilin phosphorylation.	Y 27632	13-20	cofilin 1	Homo sapiens	104-111	
12359716-8	2002	Ouabain-sensitive (86)Rb(+) uptake showed that Na,K-ATPase activity was increased by the overexpression of cofilin and lysophosphatidic acid treatment, but not by the overexpression of mutant cofilin S3A and Y-27632 treatment.	Y 27632	208-215	cofilin 1	Homo sapiens	107-114	
16125171-8	2006	Phosphorylated LIM kinase 2 and cofilin, related to actin bundling and integrin clustering, were dephosphorylated (activated) by Y-27632.	Y 27632	129-136	cofilin 1	Homo sapiens	32-39	
11294912-6	2001	Y-27632, a specific inhibitor of ROCK, inhibited LIM-kinase-induced cofilin phosphorylation but did not affect fibronectin-induced or TESK1-induced cofilin phosphorylation in HeLa cells.	Y 27632	0-7	cofilin 1	Homo sapiens	68-75	
30369081-9	2018	Additionally, preincubation of Y-27632 decreased the ouabain-induced the phosphorylation of MYPT and cofilin.	Y 27632	31-38	cofilin 1	Homo sapiens	101-108