PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24370186-10 2014 Proliferation and cytoskeletal rearrangement were suppressed by pre-treatment with the ROCK inhibitor Y-27632; additionally, expression of ROCK protein and phosphorylation of LIM kinase and cofilin were decreased by Y-27632, while Rho-GDIa knockdown by targeted siRNA transfection causes opposite effects. Y 27632 102-109 cofilin 1 Homo sapiens 190-197 25817589-6 2015 The phosphorylation of cofilin by OPN was suppressed when cells were pretreated with ROCK inhibitor Y27632 by Western blot. Y 27632 100-106 cofilin 1 Homo sapiens 23-30 25500336-4 2015 We found that U46619, a thromboxane receptor (TP) agonist, induced the phosphorylation of cofilin, a target of Rho-kinase signaling, and that the cofilin phosphorylation by U46619 was suppressed by Y27632 or fasudil, specific inhibitors of Rho-kinase. Y 27632 198-204 cofilin 1 Homo sapiens 90-97 25500336-4 2015 We found that U46619, a thromboxane receptor (TP) agonist, induced the phosphorylation of cofilin, a target of Rho-kinase signaling, and that the cofilin phosphorylation by U46619 was suppressed by Y27632 or fasudil, specific inhibitors of Rho-kinase. Y 27632 198-204 cofilin 1 Homo sapiens 146-153 19649725-6 2010 We found that Y-27632 increased both heterotypic and homotypic adhesion, and the expression of E-cadherin; decreased phosphorylated cofilin resulting in actin rearrangement in ESCC cells. Y 27632 14-21 cofilin 1 Homo sapiens 132-139 23951242-10 2013 In endothelial cells, LIMK-mediated cofilin phosphorylation after thrombin-stimulation of EGFP- or DsRed2-tagged cofilin transfected cells reduced cofilin aggregate formation, whereas inhibition of cofilin phosphorylation after Rho-kinase inhibitor (Y27632) treatment of endothelial cells promoted formation of cofilin aggregates. Y 27632 250-256 cofilin 1 Homo sapiens 36-43 23951242-11 2013 In platelets, cofilin dephosphorylation after thrombin-stimulation and Y27632 treatment led to an increased formation of the cofilin oligomer. Y 27632 71-77 cofilin 1 Homo sapiens 125-132 23337538-11 2013 Estrogen-induced phosphorylation of cofilin was inhibited by Y-27632, a specific inhibitor of the Rho-associated protein serine/threonine kinase (ROCK). Y 27632 61-68 cofilin 1 Homo sapiens 36-43 21769918-8 2011 Treatment with Y-27632, a specific ROCK inhibitor, we found that dysregulation of ROCK/cofilin pathway decreased p-cofilin expression and induced cell migration. Y 27632 15-22 cofilin 1 Homo sapiens 87-94 21769918-8 2011 Treatment with Y-27632, a specific ROCK inhibitor, we found that dysregulation of ROCK/cofilin pathway decreased p-cofilin expression and induced cell migration. Y 27632 15-22 cofilin 1 Homo sapiens 115-122 19144696-8 2009 Treatment with Y-27632, an inhibitor of the RhoA effector p160-ROCK, decreased levels of phosphorylated cofilin and reduced stress fiber fluorescence by 22%. Y 27632 15-22 cofilin 1 Homo sapiens 104-111 19144696-9 2009 In cells treated with Y-27632 followed by treatment with the cytokine cocktail, stress fiber levels were similar to control cells and cofilin phosphorylation was 55% of control levels. Y 27632 22-29 cofilin 1 Homo sapiens 134-141 17321765-7 2007 Pretreatment with the Rho-kinase inhibitor Y-27632 inhibited LIMK-1 phosphorylation, unmasked cofilin dephosphorylation and inhibited the reversible F-actin increase during shape change. Y 27632 43-50 cofilin 1 Homo sapiens 94-101 17138966-8 2007 Y-27632 reduced the levels of both active LIMK-1 and inactive cofilin (phospho forms), and expression of a dominant negative LIMK-1 mutant stimulated leading edge protrusiveness. Y 27632 0-7 cofilin 1 Homo sapiens 62-69 17138966-9 2007 Furthermore, Y-27632-induced protrusions were partially reversed by overexpression of LIMK-1 to restore cofilin phosphorylation. Y 27632 13-20 cofilin 1 Homo sapiens 104-111 12359716-8 2002 Ouabain-sensitive (86)Rb(+) uptake showed that Na,K-ATPase activity was increased by the overexpression of cofilin and lysophosphatidic acid treatment, but not by the overexpression of mutant cofilin S3A and Y-27632 treatment. Y 27632 208-215 cofilin 1 Homo sapiens 107-114 16125171-8 2006 Phosphorylated LIM kinase 2 and cofilin, related to actin bundling and integrin clustering, were dephosphorylated (activated) by Y-27632. Y 27632 129-136 cofilin 1 Homo sapiens 32-39 11294912-6 2001 Y-27632, a specific inhibitor of ROCK, inhibited LIM-kinase-induced cofilin phosphorylation but did not affect fibronectin-induced or TESK1-induced cofilin phosphorylation in HeLa cells. Y 27632 0-7 cofilin 1 Homo sapiens 68-75 30369081-9 2018 Additionally, preincubation of Y-27632 decreased the ouabain-induced the phosphorylation of MYPT and cofilin. Y 27632 31-38 cofilin 1 Homo sapiens 101-108