PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31648394-2	2020	Suppressing HTT production with antisense oligonucleotides (ASOs) is a promising treatment strategy for HD; however, the difficulty of delivering ASOs to deep brain structures is a major barrier for its clinical application.	Oligonucleotides, Antisense	60-64	huntingtin	Mus musculus	12-15	
28453524-4	2017	To test this hypothesis, we lowered levels of huntingtin by treating mice with antisense oligonucleotides (ASOs) targeting the murine Huntingtin gene.	Oligonucleotides, Antisense	107-111	huntingtin	Mus musculus	46-56	
28453524-4	2017	To test this hypothesis, we lowered levels of huntingtin by treating mice with antisense oligonucleotides (ASOs) targeting the murine Huntingtin gene.	Oligonucleotides, Antisense	107-111	huntingtin	Mus musculus	134-144	
28453524-7	2017	Peripheral treatment with ASOs led to persistent reduction of huntingtin protein in peripheral organs, including liver (64% knockdown), brown adipose (66% knockdown), and white adipose tissues (71% knockdown).	Oligonucleotides, Antisense	26-30	huntingtin	Mus musculus	62-72	
25035419-4	2014	Antisense oligonucleotides (ASOs) targeted to the CAG repeat region of HTT transcripts have been of particular interest due to their potential capacity to discriminate between normal and mutant HTT transcripts.	Oligonucleotides, Antisense	28-32	huntingtin	Mus musculus	71-74	
25035419-4	2014	Antisense oligonucleotides (ASOs) targeted to the CAG repeat region of HTT transcripts have been of particular interest due to their potential capacity to discriminate between normal and mutant HTT transcripts.	Oligonucleotides, Antisense	28-32	huntingtin	Mus musculus	194-197	
22726826-3	2012	(2012) show the benefit of transient antisense oligonucleotide (ASO) therapy to degrade Huntingtin mRNA and elicit sustained therapeutic benefit in HD mice.	Oligonucleotides, Antisense	64-67	huntingtin	Mus musculus	88-98	
30282695-3	2018	We previously identified HTT single-nucleotide polymorphisms (SNPs) tightly linked to the HD mutation and developed antisense oligonucleotides (ASOs) targeting HD-SNPs that selectively suppress mutant HTT.	Oligonucleotides, Antisense	144-148	huntingtin	Mus musculus	25-28	
30282695-3	2018	We previously identified HTT single-nucleotide polymorphisms (SNPs) tightly linked to the HD mutation and developed antisense oligonucleotides (ASOs) targeting HD-SNPs that selectively suppress mutant HTT.	Oligonucleotides, Antisense	144-148	huntingtin	Mus musculus	201-204	
30282695-6	2018	To determine the translational potential of the treatment, we examined the effect of ASO administration on HTT brain expression in nonhuman primates.	Oligonucleotides, Antisense	85-88	huntingtin	Mus musculus	107-110